Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SORC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SORC2_HUMAN
GO:0043121 neurotrophin binding 50.0000 4 no
GO:0004930 G protein-coupled receptor activity 50.0000 4 yes
GO:0008188 neuropeptide receptor activity 50.0000 5 yes
GO:0008528 G protein-coupled peptide receptor activity 50.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SORC2_HUMAN
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 100.0000 5 yes
GO:0071702 organic substance transport 100.0000 4 yes
GO:0071705 nitrogen compound transport 100.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 100.0000 4 yes
GO:0006886 intracellular protein transport 75.0000 4 yes
GO:0008104 protein localization 75.0000 4 yes
GO:0010648 negative regulation of cell communication 75.0000 5 yes
GO:0015031 protein transport 75.0000 4 yes
GO:0023057 negative regulation of signaling 75.0000 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0042981 regulation of apoptotic process 50.0000 5 no
GO:0043067 regulation of programmed cell death 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051094 positive regulation of developmental process 50.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051336 regulation of hydrolase activity 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:2000026 regulation of multicellular organismal development 50.0000 4 no
GO:0007218 neuropeptide signaling pathway 50.0000 4 yes
GO:0050805 negative regulation of synaptic transmission 50.0000 5 yes
GO:0060292 long-term synaptic depression 50.0000 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 50.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 50.0000 5 no
GO:0008284 positive regulation of cell population proliferation 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
NGF_HUMAN [view interactions] Low throughput no no
NTF3_HUMAN [view interactions] Low throughput no no
BDNF_HUMAN [view interactions] Low throughput no yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SORC2_HUMAN [view entry] [view interactions] Low throughput yes no
HNRPU_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
MYH4_HUMAN [view interactions] High throughput no no
TTC1_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
CSTFT_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
SORL_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes