Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SORC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SORC2_HUMAN
GO:0004930 G protein-coupled receptor activity 40.0000 4 yes
GO:0008188 neuropeptide receptor activity 40.0000 5 yes
GO:0008528 G protein-coupled peptide receptor activity 40.0000 4 yes
GO:0043121 neurotrophin binding 40.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SORC2_HUMAN
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0048523 negative regulation of cellular process 100.0000 4 yes
GO:0071702 organic substance transport 100.0000 4 yes
GO:0071705 nitrogen compound transport 100.0000 4 yes
GO:0006886 intracellular protein transport 80.0000 4 yes
GO:0008104 protein localization 80.0000 4 yes
GO:0015031 protein transport 80.0000 4 yes
GO:0010648 negative regulation of cell communication 60.0000 5 yes
GO:0023057 negative regulation of signaling 60.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 60.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 60.0000 4 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0009966 regulation of signal transduction 60.0000 4 no
GO:0009967 positive regulation of signal transduction 60.0000 5 no
GO:0010468 regulation of gene expression 60.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0010647 positive regulation of cell communication 60.0000 5 no
GO:0010941 regulation of cell death 60.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 60.0000 4 no
GO:0023056 positive regulation of signaling 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0048584 positive regulation of response to stimulus 60.0000 4 no
GO:0051094 positive regulation of developmental process 60.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 60.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 60.0000 4 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0051247 positive regulation of protein metabolic process 60.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 no
GO:0080090 regulation of primary metabolic process 60.0000 4 no
GO:0007218 neuropeptide signaling pathway 40.0000 4 yes
GO:0050805 negative regulation of synaptic transmission 40.0000 5 yes
GO:0060292 long-term synaptic depression 40.0000 4 yes
GO:0008284 positive regulation of cell population proliferation 40.0000 5 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010243 response to organonitrogen compound 40.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0042981 regulation of apoptotic process 40.0000 6 no
GO:0043067 regulation of programmed cell death 40.0000 5 no
GO:0043085 positive regulation of catalytic activity 40.0000 4 no
GO:0048585 negative regulation of response to stimulus 40.0000 4 no
GO:0051336 regulation of hydrolase activity 40.0000 4 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0071417 cellular response to organonitrogen compound 40.0000 4 no
GO:1901699 cellular response to nitrogen compound 40.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 40.0000 4 no
GO:1903829 positive regulation of protein localization 40.0000 5 no
GO:2000026 regulation of multicellular organismal development 40.0000 4 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0010628 positive regulation of gene expression 40.0000 6 no
GO:0031344 regulation of cell projection organization 40.0000 5 no
GO:0044087 regulation of cellular component biogenesis 40.0000 4 no
GO:0050807 regulation of synapse organization 40.0000 5 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0051248 negative regulation of protein metabolic process 40.0000 6 no
GO:0051963 regulation of synapse assembly 40.0000 6 no
GO:0060548 negative regulation of cell death 40.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 no
GO:1901214 regulation of neuron death 40.0000 5 no
GO:1901215 negative regulation of neuron death 40.0000 6 no
GO:1901888 regulation of cell junction assembly 40.0000 5 no

Disease

Term Name % Distance from top the of the tree Annotated in SORC2_HUMAN
DOID:331 central nervous system disease 40.0000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
NTF3_HUMAN [view interactions] Low throughput no no
BDNF_HUMAN [view interactions] Low throughput no yes
NGF_HUMAN [view interactions] Low throughput no no
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SORC2_HUMAN [view entry] [view interactions] Low throughput yes no
HNRPU_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NXT2_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
MYH4_HUMAN [view interactions] High throughput no no
TTC1_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
CSTFT_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
SORL_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] Computational yes yes