ELFN1_HUMAN
Evidence for PS localization
Functions
Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses . Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ELFN1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 33.3333 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 26.6667 | 4 | no |
| GO:0008066 | glutamate receptor activity | 26.6667 | 4 | no |
| GO:0015267 | channel activity | 26.6667 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.6667 | 4 | no |
| GO:0043168 | anion binding | 26.6667 | 4 | no |
| GO:0030165 | PDZ domain binding | 26.6667 | 4 | no |
| GO:0004864 | protein phosphatase inhibitor activity | 13.3333 | 5 | yes |
| GO:0019212 | phosphatase inhibitor activity | 13.3333 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 13.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ELFN1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 73.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 60.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 33.3333 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
| GO:0050890 | cognition | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 33.3333 | 6 | no |
| GO:0099536 | synaptic signaling | 33.3333 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
| GO:0051049 | regulation of transport | 26.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.6667 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.6667 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.6667 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 26.6667 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.6667 | 4 | no |
| GO:0034330 | cell junction organization | 20.0000 | 4 | yes |
| GO:0050808 | synapse organization | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRM6_HUMAN | [view interactions] | Low throughput | no | no |
| GRM7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM4_HUMAN | [view interactions] | Low throughput | no | no |
| GRM8_HUMAN | [view interactions] | Low throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPR29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |