Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
154 Ile Thr Neurodevelopmentaldisorderwithseizures,hypotonia,andbrainimagingabnormalities(NEDSHBA) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM7_HUMAN
GO:0043169 cation binding 56.5217 4 yes
GO:0046872 metal ion binding 56.5217 5 yes
GO:0043168 anion binding 34.7826 4 yes
GO:0019900 kinase binding 34.7826 4 no
GO:0019901 protein kinase binding 30.4348 5 no
GO:0005509 calcium ion binding 21.7391 6 yes
GO:0010854 adenylate cyclase regulator activity 21.7391 4 yes
GO:0001664 G protein-coupled receptor binding 21.7391 4 no
GO:0019888 protein phosphatase regulator activity 21.7391 4 no
GO:0000166 nucleotide binding 21.7391 4 no
GO:0017076 purine nucleotide binding 21.7391 5 no
GO:0032555 purine ribonucleotide binding 21.7391 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.7391 4 no
GO:0030165 PDZ domain binding 13.0435 4 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 8.6957 6 yes
GO:0001642 group III metabotropic glutamate receptor activity 8.6957 7 yes
GO:0004930 G protein-coupled receptor activity 8.6957 4 yes
GO:0008066 glutamate receptor activity 8.6957 4 yes
GO:0010852 cyclase inhibitor activity 8.6957 4 yes
GO:0010855 adenylate cyclase inhibitor activity 8.6957 5 yes
GO:0031406 carboxylic acid binding 8.6957 4 yes
GO:0098988 G protein-coupled glutamate receptor activity 8.6957 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM7_HUMAN
GO:0048523 negative regulation of cellular process 73.9130 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.2174 4 no
GO:0010646 regulation of cell communication 65.2174 4 yes
GO:0048522 positive regulation of cellular process 60.8696 4 no
GO:0031323 regulation of cellular metabolic process 60.8696 4 no
GO:0080090 regulation of primary metabolic process 56.5217 4 no
GO:0051049 regulation of transport 56.5217 4 yes
GO:0009966 regulation of signal transduction 43.4783 4 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0022607 cellular component assembly 39.1304 4 no
GO:0009889 regulation of biosynthetic process 39.1304 4 no
GO:0009892 negative regulation of metabolic process 39.1304 4 no
GO:0010468 regulation of gene expression 39.1304 6 no
GO:0010556 regulation of macromolecule biosynthetic process 39.1304 5 no
GO:0010605 negative regulation of macromolecule metabolic process 39.1304 5 no
GO:0031324 negative regulation of cellular metabolic process 39.1304 5 no
GO:0031326 regulation of cellular biosynthetic process 39.1304 5 no
GO:0006996 organelle organization 34.7826 4 no
GO:0051050 positive regulation of transport 34.7826 4 no
GO:0051128 regulation of cellular component organization 34.7826 4 no
GO:0051051 negative regulation of transport 34.7826 4 yes
GO:0009893 positive regulation of metabolic process 34.7826 4 no
GO:0031399 regulation of protein modification process 34.7826 6 no
GO:0036211 protein modification process 34.7826 4 no
GO:0043412 macromolecule modification 34.7826 4 no
GO:0008104 protein localization 30.4348 4 no
GO:0010647 positive regulation of cell communication 30.4348 5 no
GO:0023056 positive regulation of signaling 30.4348 4 no
GO:0051094 positive regulation of developmental process 30.4348 4 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0030030 cell projection organization 30.4348 4 yes
GO:0050804 modulation of chemical synaptic transmission 30.4348 5 yes
GO:0099177 regulation of trans-synaptic signaling 30.4348 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.4348 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 no
GO:0051247 positive regulation of protein metabolic process 30.4348 6 no
GO:0051252 regulation of RNA metabolic process 30.4348 5 no
GO:2001141 regulation of RNA biosynthetic process 26.0870 6 no
GO:0009967 positive regulation of signal transduction 26.0870 5 no
GO:0048584 positive regulation of response to stimulus 26.0870 4 no
GO:0051129 negative regulation of cellular component organization 26.0870 5 no
GO:0072657 protein localization to membrane 26.0870 4 no
GO:0043933 protein-containing complex organization 26.0870 4 no
GO:0019220 regulation of phosphate metabolic process 26.0870 6 no
GO:0031325 positive regulation of cellular metabolic process 26.0870 5 no
GO:0042325 regulation of phosphorylation 26.0870 7 no
GO:0043085 positive regulation of catalytic activity 26.0870 4 no
GO:0051174 regulation of phosphorus metabolic process 26.0870 5 no
GO:0051338 regulation of transferase activity 26.0870 4 no
GO:0051046 regulation of secretion 26.0870 5 yes
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 yes
GO:1903530 regulation of secretion by cell 26.0870 4 yes
GO:0006355 regulation of DNA-templated transcription 26.0870 7 no
GO:0031401 positive regulation of protein modification process 26.0870 7 no
GO:0051248 negative regulation of protein metabolic process 26.0870 6 no
GO:0051253 negative regulation of RNA metabolic process 21.7391 6 no
GO:1902679 negative regulation of RNA biosynthetic process 21.7391 7 no
GO:0010959 regulation of metal ion transport 21.7391 6 no
GO:0030334 regulation of cell migration 21.7391 5 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0034762 regulation of transmembrane transport 21.7391 4 no
GO:0042127 regulation of cell population proliferation 21.7391 4 no
GO:0042981 regulation of apoptotic process 21.7391 5 no
GO:0043067 regulation of programmed cell death 21.7391 4 no
GO:0043269 regulation of monoatomic ion transport 21.7391 5 no
GO:0043270 positive regulation of monoatomic ion transport 21.7391 5 no
GO:0044087 regulation of cellular component biogenesis 21.7391 4 no
GO:0051130 positive regulation of cellular component organization 21.7391 5 no
GO:2000145 regulation of cell motility 21.7391 4 no
GO:0065003 protein-containing complex assembly 21.7391 5 no
GO:0001932 regulation of protein phosphorylation 21.7391 7 no
GO:0010038 response to metal ion 21.7391 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.7391 6 no
GO:0042327 positive regulation of phosphorylation 21.7391 8 no
GO:0043549 regulation of kinase activity 21.7391 5 no
GO:0044057 regulation of system process 21.7391 4 no
GO:0044772 mitotic cell cycle phase transition 21.7391 4 no
GO:0045859 regulation of protein kinase activity 21.7391 6 no
GO:0045937 positive regulation of phosphate metabolic process 21.7391 7 no
GO:0051336 regulation of hydrolase activity 21.7391 4 no
GO:0051347 positive regulation of transferase activity 21.7391 5 no
GO:0051726 regulation of cell cycle 21.7391 4 no
GO:0141124 intracellular signaling cassette 21.7391 4 no
GO:0060627 regulation of vesicle-mediated transport 21.7391 4 no
GO:0061024 membrane organization 21.7391 4 no
GO:0034097 response to cytokine 21.7391 4 no
GO:0007268 chemical synaptic transmission 21.7391 7 yes
GO:0098916 anterograde trans-synaptic signaling 21.7391 6 yes
GO:0099536 synaptic signaling 21.7391 4 yes
GO:0099537 trans-synaptic signaling 21.7391 5 yes
GO:0009890 negative regulation of biosynthetic process 21.7391 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.7391 6 no
GO:0018193 peptidyl-amino acid modification 21.7391 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.7391 6 no
GO:0031400 negative regulation of protein modification process 21.7391 7 no
GO:0045595 regulation of cell differentiation 21.7391 4 no
GO:0045892 negative regulation of DNA-templated transcription 21.7391 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.7391 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 17.3913 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 13.0435 5 yes
GO:0007215 glutamate receptor signaling pathway 13.0435 4 yes
GO:0014048 regulation of glutamate secretion 13.0435 5 yes
GO:0031175 neuron projection development 13.0435 6 yes
GO:0032890 regulation of organic acid transport 13.0435 5 yes
GO:0051952 regulation of amine transport 13.0435 5 yes
GO:0051955 regulation of amino acid transport 13.0435 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 13.0435 6 yes
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway 8.6957 5 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 8.6957 4 yes
GO:0007600 sensory perception 8.6957 4 yes
GO:0007605 sensory perception of sound 8.6957 6 yes
GO:0014050 negative regulation of glutamate secretion 8.6957 6 yes
GO:0032891 negative regulation of organic acid transport 8.6957 5 yes
GO:0050954 sensory perception of mechanical stimulus 8.6957 5 yes
GO:0051048 negative regulation of secretion 8.6957 5 yes
GO:0051953 negative regulation of amine transport 8.6957 5 yes
GO:0051956 negative regulation of amino acid transport 8.6957 6 yes
GO:0061564 axon development 8.6957 7 yes
GO:1903531 negative regulation of secretion by cell 8.6957 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ELFN1_HUMAN [view entry] [view interactions] Low throughput yes no
PPR29_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM7_HUMAN [view entry] [view interactions] Low throughput yes no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
GRM4_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
CBX4_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
UBP26_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes