Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
154 Ile Thr Neurodevelopmentaldisorderwithseizures,hypotonia,andbrainimagingabnormalities(NEDSHBA) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM7_HUMAN
GO:0046872 metal ion binding 52.6316 4 yes
GO:0019900 kinase binding 42.1053 4 no
GO:0019901 protein kinase binding 42.1053 5 no
GO:0001664 G protein-coupled receptor binding 31.5789 4 no
GO:0005509 calcium ion binding 26.3158 5 yes
GO:0017076 purine nucleotide binding 26.3158 4 no
GO:0032555 purine ribonucleotide binding 26.3158 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.3158 4 no
GO:0003723 RNA binding 21.0526 4 no
GO:0019888 protein phosphatase regulator activity 21.0526 4 no
GO:0030165 PDZ domain binding 15.7895 4 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 10.5263 6 yes
GO:0001642 group III metabotropic glutamate receptor activity 10.5263 7 yes
GO:0004930 G protein-coupled receptor activity 10.5263 4 yes
GO:0008066 glutamate receptor activity 10.5263 4 yes
GO:0010852 cyclase inhibitor activity 10.5263 4 yes
GO:0010854 adenylate cyclase regulator activity 10.5263 5 yes
GO:0010855 adenylate cyclase inhibitor activity 10.5263 6 yes
GO:0016595 glutamate binding 10.5263 5 yes
GO:0016597 amino acid binding 10.5263 4 yes
GO:0031406 carboxylic acid binding 10.5263 4 yes
GO:0070905 serine binding 10.5263 4 yes
GO:0098988 G protein-coupled glutamate receptor activity 10.5263 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM7_HUMAN
GO:0010646 regulation of cell communication 73.6842 4 yes
GO:0048523 negative regulation of cellular process 68.4211 4 yes
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0051049 regulation of transport 63.1579 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 no
GO:0009966 regulation of signal transduction 52.6316 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.6316 4 no
GO:0080090 regulation of primary metabolic process 52.6316 4 no
GO:0031323 regulation of cellular metabolic process 47.3684 4 no
GO:0043269 regulation of ion transport 47.3684 5 yes
GO:0006996 organelle organization 47.3684 4 no
GO:0051128 regulation of cellular component organization 42.1053 4 no
GO:0051050 positive regulation of transport 42.1053 4 no
GO:0051246 regulation of protein metabolic process 42.1053 5 no
GO:0008104 protein localization 36.8421 4 no
GO:0072657 protein localization to membrane 36.8421 4 no
GO:0030030 cell projection organization 36.8421 4 yes
GO:0050804 modulation of chemical synaptic transmission 36.8421 5 yes
GO:0051046 regulation of secretion 36.8421 5 yes
GO:0051051 negative regulation of transport 36.8421 4 yes
GO:0099177 regulation of trans-synaptic signaling 36.8421 4 yes
GO:0120036 plasma membrane bounded cell projection organization 36.8421 5 yes
GO:1903530 regulation of secretion by cell 36.8421 4 yes
GO:1902531 regulation of intracellular signal transduction 36.8421 5 no
GO:0051094 positive regulation of developmental process 31.5789 4 no
GO:0001932 regulation of protein phosphorylation 31.5789 7 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0019220 regulation of phosphate metabolic process 31.5789 6 no
GO:0031324 negative regulation of cellular metabolic process 31.5789 5 no
GO:0031399 regulation of protein modification process 31.5789 6 no
GO:0042325 regulation of phosphorylation 31.5789 7 no
GO:0043270 positive regulation of ion transport 31.5789 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.5789 5 no
GO:0051174 regulation of phosphorus metabolic process 31.5789 5 no
GO:0051248 negative regulation of protein metabolic process 31.5789 6 no
GO:0009893 positive regulation of metabolic process 31.5789 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.5789 5 no
GO:0022607 cellular component assembly 31.5789 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0036211 protein modification process 31.5789 4 no
GO:0043412 macromolecule modification 31.5789 4 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0010941 regulation of cell death 26.3158 4 no
GO:0010959 regulation of metal ion transport 26.3158 6 no
GO:0031325 positive regulation of cellular metabolic process 26.3158 5 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0034762 regulation of transmembrane transport 26.3158 4 no
GO:0034765 regulation of ion transmembrane transport 26.3158 5 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0042981 regulation of apoptotic process 26.3158 6 no
GO:0043067 regulation of programmed cell death 26.3158 5 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0043549 regulation of kinase activity 26.3158 5 no
GO:0044057 regulation of system process 26.3158 4 no
GO:0045859 regulation of protein kinase activity 26.3158 6 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0051336 regulation of hydrolase activity 26.3158 4 no
GO:0051338 regulation of transferase activity 26.3158 4 no
GO:0051726 regulation of cell cycle 26.3158 4 no
GO:0060627 regulation of vesicle-mediated transport 26.3158 4 no
GO:1904062 regulation of cation transmembrane transport 26.3158 6 no
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0051129 negative regulation of cellular component organization 26.3158 5 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0007268 chemical synaptic transmission 26.3158 6 yes
GO:0043271 negative regulation of ion transport 26.3158 5 yes
GO:0098916 anterograde trans-synaptic signaling 26.3158 5 yes
GO:0099537 trans-synaptic signaling 26.3158 4 yes
GO:0007010 cytoskeleton organization 26.3158 5 no
GO:0006796 phosphate-containing compound metabolic process 26.3158 4 no
GO:0010468 regulation of gene expression 26.3158 5 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0045597 positive regulation of cell differentiation 21.0526 5 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0001933 negative regulation of protein phosphorylation 21.0526 8 no
GO:0006468 protein phosphorylation 21.0526 5 no
GO:0010038 response to metal ion 21.0526 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.0526 6 no
GO:0016310 phosphorylation 21.0526 5 no
GO:0022898 regulation of transmembrane transporter activity 21.0526 4 no
GO:0030100 regulation of endocytosis 21.0526 5 no
GO:0031400 negative regulation of protein modification process 21.0526 7 no
GO:0032412 regulation of ion transmembrane transporter activity 21.0526 5 no
GO:0033674 positive regulation of kinase activity 21.0526 6 no
GO:0034764 positive regulation of transmembrane transport 21.0526 5 no
GO:0034767 positive regulation of ion transmembrane transport 21.0526 6 no
GO:0042326 negative regulation of phosphorylation 21.0526 8 no
GO:0044772 mitotic cell cycle phase transition 21.0526 4 no
GO:0045860 positive regulation of protein kinase activity 21.0526 7 no
GO:0045936 negative regulation of phosphate metabolic process 21.0526 7 no
GO:0051345 positive regulation of hydrolase activity 21.0526 5 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0051924 regulation of calcium ion transport 21.0526 7 no
GO:0051928 positive regulation of calcium ion transport 21.0526 6 no
GO:0061024 membrane organization 21.0526 4 no
GO:0090257 regulation of muscle system process 21.0526 5 no
GO:1904064 positive regulation of cation transmembrane transport 21.0526 7 no
GO:2001257 regulation of cation channel activity 21.0526 6 no
GO:0009967 positive regulation of signal transduction 21.0526 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:1990778 protein localization to cell periphery 21.0526 5 no
GO:0006886 intracellular protein transport 21.0526 4 no
GO:0015031 protein transport 21.0526 4 no
GO:0016192 vesicle-mediated transport 21.0526 4 no
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0044087 regulation of cellular component biogenesis 21.0526 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0030334 regulation of cell migration 21.0526 5 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:2000145 regulation of cell motility 21.0526 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 21.0526 4 yes
GO:0031175 neuron projection development 21.0526 6 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 15.7895 5 yes
GO:0007215 glutamate receptor signaling pathway 15.7895 4 yes
GO:0014048 regulation of glutamate secretion 15.7895 5 yes
GO:0032890 regulation of organic acid transport 15.7895 5 yes
GO:0044070 regulation of anion transport 15.7895 6 yes
GO:0051952 regulation of amine transport 15.7895 5 yes
GO:0051955 regulation of amino acid transport 15.7895 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 15.7895 6 yes
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway 10.5263 5 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 10.5263 4 yes
GO:0007600 sensory perception 10.5263 4 yes
GO:0007605 sensory perception of sound 10.5263 6 yes
GO:0014050 negative regulation of glutamate secretion 10.5263 6 yes
GO:0032891 negative regulation of organic acid transport 10.5263 5 yes
GO:0050954 sensory perception of mechanical stimulus 10.5263 5 yes
GO:0051048 negative regulation of secretion 10.5263 5 yes
GO:0051953 negative regulation of amine transport 10.5263 5 yes
GO:0051956 negative regulation of amino acid transport 10.5263 6 yes
GO:0061564 axon development 10.5263 7 yes
GO:1903531 negative regulation of secretion by cell 10.5263 5 yes
GO:1903792 negative regulation of anion transport 10.5263 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GRM7_HUMAN
DOID:114 heart disease 15.7895 3 no
DOID:0050700 cardiomyopathy 10.5263 4 no
DOID:0060036 intrinsic cardiomyopathy 10.5263 5 no
DOID:2843 long QT syndrome 10.5263 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ELFN1_HUMAN [view interactions] Low throughput no no
PPR29_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM7_HUMAN [view entry] [view interactions] Low throughput yes no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
GRM4_HUMAN [view interactions] High throughput no no
PIAS1_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view interactions] High throughput no yes
CBX4_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
UBP26_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
GRM8_HUMAN [view interactions] Computational no no