RN216_HUMAN
Evidence for PS localization
Functions
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RN216_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 5 | yes |
| GO:0008270 | zinc ion binding | 40.0000 | 7 | yes |
| GO:0016755 | aminoacyltransferase activity | 40.0000 | 4 | yes |
| GO:0046914 | transition metal ion binding | 40.0000 | 6 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 40.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 40.0000 | 4 | no |
| GO:0003723 | RNA binding | 40.0000 | 4 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 30.0000 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 30.0000 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 30.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RN216_HUMAN |
|---|---|---|---|---|
| GO:0036211 | protein modification process | 80.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 80.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 80.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 60.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 60.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 60.0000 | 5 | yes |
| GO:0032446 | protein modification by small protein conjugation | 60.0000 | 7 | yes |
| GO:0043687 | post-translational protein modification | 60.0000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 60.0000 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 60.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | yes |
| GO:0016567 | protein ubiquitination | 50.0000 | 8 | yes |
| GO:0030162 | regulation of proteolysis | 50.0000 | 6 | no |
| GO:0006508 | proteolysis | 40.0000 | 4 | yes |
| GO:0006915 | apoptotic process | 40.0000 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:0080134 | regulation of response to stress | 40.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0000209 | protein polyubiquitination | 30.0000 | 9 | yes |
| GO:0001817 | regulation of cytokine production | 30.0000 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 30.0000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 30.0000 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 30.0000 | 6 | yes |
| GO:0031347 | regulation of defense response | 30.0000 | 5 | yes |
| GO:0032479 | regulation of type I interferon production | 30.0000 | 5 | yes |
| GO:0032648 | regulation of interferon-beta production | 30.0000 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 30.0000 | 5 | yes |
| GO:0050688 | regulation of defense response to virus | 30.0000 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 30.0000 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 30.0000 | 6 | no |
| GO:0042176 | regulation of protein catabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0061136 | regulation of proteasomal protein catabolic process | 30.0000 | 6 | no |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 30.0000 | 7 | no |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 30.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
| GO:0001818 | negative regulation of cytokine production | 20.0000 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 20.0000 | 7 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 20.0000 | 4 | yes |
| GO:0010498 | proteasomal protein catabolic process | 20.0000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.0000 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 20.0000 | 7 | yes |
| GO:0030163 | protein catabolic process | 20.0000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 20.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0032480 | negative regulation of type I interferon production | 20.0000 | 6 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 20.0000 | 6 | yes |
| GO:0050691 | regulation of defense response to virus by host | 20.0000 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0070936 | protein K48-linked ubiquitination | 20.0000 | 10 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L6_HUMAN | [view interactions] | Low throughput | no | no |
| TLR3_HUMAN | [view interactions] | Low throughput | no | yes |
| TLR4_HUMAN | [view interactions] | Low throughput | no | yes |
| TLR5_HUMAN | [view interactions] | Low throughput | no | no |
| TLR9_HUMAN | [view interactions] | Low throughput | no | no |
| RN216_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIPK1_HUMAN | [view interactions] | Low throughput | no | yes |
| KI2L4_HUMAN | [view interactions] | Low throughput | no | no |
| FLNB_HUMAN | [view interactions] | Low throughput | no | no |
| UBE2H_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2C_HUMAN | [view interactions] | Low throughput | no | yes |
| TIRAP_HUMAN | [view interactions] | Low throughput | no | no |
| TCAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D4_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| EREP1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTURN_HUMAN | [view interactions] | High throughput | no | no |
| OTU1_HUMAN | [view interactions] | High throughput | no | yes |
| KHNYN_HUMAN | [view interactions] | High throughput | no | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN15_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | High throughput | no | yes |
| ZFN2A_HUMAN | [view interactions] | High throughput | no | yes |
| PKHN1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| RAD_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |