Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DTD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DTD1_HUMAN
GO:0000166 nucleotide binding 55.5556 4 no
GO:0017076 purine nucleotide binding 55.5556 5 no
GO:0032555 purine ribonucleotide binding 55.5556 4 no
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 no
GO:0043168 anion binding 55.5556 4 no
GO:0003723 RNA binding 44.4444 4 yes
GO:0043169 cation binding 44.4444 4 yes
GO:0046872 metal ion binding 44.4444 5 yes
GO:0004674 protein serine/threonine kinase activity 44.4444 4 no
GO:0005524 ATP binding 44.4444 5 no
GO:0016301 kinase activity 44.4444 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 44.4444 4 no
GO:0030554 adenyl nucleotide binding 44.4444 6 no
GO:0032559 adenyl ribonucleotide binding 44.4444 5 no
GO:0003677 DNA binding 33.3333 4 yes
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0000049 tRNA binding 22.2222 5 yes
GO:0002161 aminoacyl-tRNA editing activity 22.2222 5 yes
GO:0051499 D-aminoacyl-tRNA deacylase activity 22.2222 6 yes
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity 22.2222 7 yes
GO:0052689 carboxylic ester hydrolase activity 22.2222 4 yes
GO:0140101 catalytic activity, acting on a tRNA 22.2222 4 yes
GO:0051879 Hsp90 protein binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DTD1_HUMAN
GO:0009893 positive regulation of metabolic process 66.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0006996 organelle organization 55.5556 4 yes
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0009967 positive regulation of signal transduction 55.5556 5 no
GO:0010468 regulation of gene expression 55.5556 6 no
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 no
GO:0010647 positive regulation of cell communication 55.5556 5 no
GO:0023056 positive regulation of signaling 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0048584 positive regulation of response to stimulus 55.5556 4 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0051247 positive regulation of protein metabolic process 55.5556 6 no
GO:0006259 DNA metabolic process 44.4444 5 yes
GO:0090304 nucleic acid metabolic process 44.4444 4 yes
GO:0006915 apoptotic process 44.4444 4 no
GO:0030162 regulation of proteolysis 44.4444 6 no
GO:0042127 regulation of cell population proliferation 44.4444 4 no
GO:0042981 regulation of apoptotic process 44.4444 5 no
GO:0043067 regulation of programmed cell death 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009896 positive regulation of catabolic process 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0016055 Wnt signaling pathway 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0030111 regulation of Wnt signaling pathway 33.3333 5 no
GO:0030177 positive regulation of Wnt signaling pathway 33.3333 6 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 33.3333 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 33.3333 5 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0002009 morphogenesis of an epithelium 22.2222 4 no
GO:0009059 macromolecule biosynthetic process 22.2222 4 no
GO:0010467 gene expression 22.2222 5 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0071363 cellular response to growth factor stimulus 22.2222 4 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0032091 negative regulation of protein binding 22.2222 5 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0050767 regulation of neurogenesis 22.2222 6 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051100 negative regulation of binding 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051960 regulation of nervous system development 22.2222 5 no
GO:0051962 positive regulation of nervous system development 22.2222 5 no
GO:0060070 canonical Wnt signaling pathway 22.2222 5 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 22.2222 8 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 22.2222 6 no
GO:0006260 DNA replication 22.2222 6 yes
GO:0006399 tRNA metabolic process 22.2222 6 yes
GO:0016070 RNA metabolic process 22.2222 5 yes
GO:0032392 DNA geometric change 22.2222 7 yes
GO:0032508 DNA duplex unwinding 22.2222 8 yes
GO:0051276 chromosome organization 22.2222 5 yes
GO:0071103 DNA conformation change 22.2222 6 yes
GO:0001558 regulation of cell growth 22.2222 4 no
GO:0006281 DNA repair 22.2222 5 no
GO:0006974 DNA damage response 22.2222 4 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0010466 negative regulation of peptidase activity 22.2222 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010951 negative regulation of endopeptidase activity 22.2222 7 no
GO:0030307 positive regulation of cell growth 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 7 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 8 no
GO:0045732 positive regulation of protein catabolic process 22.2222 6 no
GO:0045861 negative regulation of proteolysis 22.2222 7 no
GO:0045927 positive regulation of growth 22.2222 4 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051346 negative regulation of hydrolase activity 22.2222 5 no
GO:0052547 regulation of peptidase activity 22.2222 5 no
GO:0052548 regulation of endopeptidase activity 22.2222 6 no
GO:2000116 regulation of cysteine-type endopeptidase activity 22.2222 7 no
GO:2000117 negative regulation of cysteine-type endopeptidase activity 22.2222 8 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no
GO:0000165 MAPK cascade 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0021782 glial cell development 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0048732 gland development 22.2222 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC45_HUMAN [view interactions] Low throughput no no
TOPB1_HUMAN [view interactions] Low throughput no yes
DTD1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC7_HUMAN [view interactions] Low throughput no yes
PTPA_HUMAN [view interactions] Low throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
POLK_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
NEK2_HUMAN [view interactions] High throughput no no
PLSI_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
KLH24_HUMAN [view interactions] High throughput no no
TNNC2_HUMAN [view interactions] High throughput no no
MSX2_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ANKY2_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
HARS1_HUMAN [view interactions] High throughput no yes
MA2B1_HUMAN [view interactions] High throughput no yes
SH24A_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no