Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DTD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DTD1_HUMAN
GO:0003723 RNA binding 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0003677 DNA binding 37.5000 4 yes
GO:0046872 metal ion binding 37.5000 4 yes
GO:0004674 protein serine/threonine kinase activity 37.5000 4 no
GO:0005524 ATP binding 37.5000 5 no
GO:0016301 kinase activity 37.5000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 37.5000 4 no
GO:0030554 adenyl nucleotide binding 37.5000 5 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0000049 tRNA binding 25.0000 5 yes
GO:0002161 aminoacyl-tRNA editing activity 25.0000 5 yes
GO:0051499 D-aminoacyl-tRNA deacylase activity 25.0000 6 yes
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity 25.0000 7 yes
GO:0052689 carboxylic ester hydrolase activity 25.0000 4 yes
GO:0140101 catalytic activity, acting on a tRNA 25.0000 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0051879 Hsp90 protein binding 25.0000 4 no
GO:0106310 protein serine kinase activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DTD1_HUMAN
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 62.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0018193 peptidyl-amino acid modification 37.5000 5 no
GO:0018209 peptidyl-serine modification 37.5000 6 no
GO:0030111 regulation of Wnt signaling pathway 37.5000 5 no
GO:0030162 regulation of proteolysis 37.5000 6 no
GO:0030177 positive regulation of Wnt signaling pathway 37.5000 6 no
GO:0031329 regulation of cellular catabolic process 37.5000 5 no
GO:0036211 protein modification process 37.5000 4 no
GO:0042127 regulation of cell population proliferation 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 37.5000 7 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 37.5000 4 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 37.5000 6 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0006259 DNA metabolic process 37.5000 4 yes
GO:0090304 nucleic acid metabolic process 37.5000 4 yes
GO:0006468 protein phosphorylation 37.5000 5 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0008284 positive regulation of cell population proliferation 37.5000 5 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0009896 positive regulation of catabolic process 37.5000 5 no
GO:0016055 Wnt signaling pathway 37.5000 5 no
GO:0016310 phosphorylation 37.5000 5 no
GO:0018105 peptidyl-serine phosphorylation 37.5000 6 no
GO:0030307 positive regulation of cell growth 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0045927 positive regulation of growth 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0032091 negative regulation of protein binding 25.0000 5 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051100 negative regulation of binding 25.0000 4 no
GO:0060070 canonical Wnt signaling pathway 25.0000 6 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 25.0000 8 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0006260 DNA replication 25.0000 5 yes
GO:0006399 tRNA metabolic process 25.0000 7 yes
GO:0016070 RNA metabolic process 25.0000 5 yes
GO:0034660 ncRNA metabolic process 25.0000 6 yes
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC45_HUMAN [view interactions] Low throughput no no
TOPB1_HUMAN [view interactions] Low throughput no yes
DTD1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC7_HUMAN [view interactions] Low throughput no yes
PTPA_HUMAN [view interactions] Low throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
POLK_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
NEK2_HUMAN [view interactions] High throughput no no
PLSI_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
KLH24_HUMAN [view interactions] High throughput no no
TNNC2_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ANKY2_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
HARS1_HUMAN [view interactions] High throughput no yes
MA2B1_HUMAN [view interactions] High throughput no yes
SH24A_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
DTD2_HUMAN [view interactions] Computational no yes