Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DGKQ_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed, PubMed, PubMed). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed, PubMed, PubMed). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor . Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DGKQ_HUMAN
GO:0046872 metal ion binding 66.6667 4 yes
GO:0017076 purine nucleotide binding 55.5556 4 yes
GO:0032555 purine ribonucleotide binding 55.5556 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 yes
GO:0005525 GTP binding 44.4444 5 no
GO:0019001 guanyl nucleotide binding 44.4444 5 no
GO:0032561 guanyl ribonucleotide binding 44.4444 5 no
GO:0045296 cadherin binding 44.4444 4 no
GO:0005524 ATP binding 33.3333 5 yes
GO:0019900 kinase binding 33.3333 4 yes
GO:0030554 adenyl nucleotide binding 33.3333 5 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0005509 calcium ion binding 33.3333 5 no
GO:0003723 RNA binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017022 myosin binding 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0019003 GDP binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DGKQ_HUMAN
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 77.7778 4 yes
GO:0051246 regulation of protein metabolic process 77.7778 5 yes
GO:0071310 cellular response to organic substance 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0060627 regulation of vesicle-mediated transport 55.5556 4 yes
GO:0006996 organelle organization 55.5556 4 no
GO:0022607 cellular component assembly 55.5556 4 no
GO:0030030 cell projection organization 55.5556 4 no
GO:0009889 regulation of biosynthetic process 55.5556 4 yes
GO:0009893 positive regulation of metabolic process 55.5556 4 yes
GO:0010243 response to organonitrogen compound 55.5556 4 yes
GO:0010468 regulation of gene expression 55.5556 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 yes
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 55.5556 5 yes
GO:0051247 positive regulation of protein metabolic process 55.5556 6 yes
GO:0051252 regulation of RNA metabolic process 44.4444 5 yes
GO:1902531 regulation of intracellular signal transduction 44.4444 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 44.4444 7 yes
GO:2001141 regulation of RNA biosynthetic process 44.4444 6 yes
GO:0008104 protein localization 44.4444 4 no
GO:0016192 vesicle-mediated transport 44.4444 4 no
GO:0070925 organelle assembly 44.4444 5 no
GO:0072657 protein localization to membrane 44.4444 4 no
GO:0072659 protein localization to plasma membrane 44.4444 5 no
GO:1990778 protein localization to cell periphery 44.4444 5 no
GO:0051094 positive regulation of developmental process 44.4444 4 no
GO:1901701 cellular response to oxygen-containing compound 44.4444 4 no
GO:0006355 regulation of DNA-templated transcription 44.4444 6 yes
GO:0009892 negative regulation of metabolic process 44.4444 4 yes
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0010628 positive regulation of gene expression 44.4444 6 yes
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0014070 response to organic cyclic compound 44.4444 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 yes
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 yes
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 yes
GO:0048523 negative regulation of cellular process 44.4444 4 yes
GO:0006897 endocytosis 33.3333 5 no
GO:0016197 endosomal transport 33.3333 4 no
GO:0030031 cell projection assembly 33.3333 5 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0051259 protein complex oligomerization 33.3333 6 no
GO:0051260 protein homooligomerization 33.3333 7 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0098876 vesicle-mediated transport to the plasma membrane 33.3333 4 no
GO:0120031 plasma membrane bounded cell projection assembly 33.3333 6 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0045927 positive regulation of growth 33.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 33.3333 6 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 yes
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 7 yes
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0042325 regulation of phosphorylation 33.3333 7 yes
GO:0042327 positive regulation of phosphorylation 33.3333 8 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0051591 response to cAMP 22.2222 4 yes
GO:0032456 endocytic recycling 22.2222 5 no
GO:0044782 cilium organization 22.2222 5 no
GO:0060271 cilium assembly 22.2222 6 no
GO:0070848 response to growth factor 22.2222 4 no
GO:0071363 cellular response to growth factor stimulus 22.2222 5 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0002683 negative regulation of immune system process 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0007015 actin filament organization 22.2222 5 no
GO:0008360 regulation of cell shape 22.2222 6 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0030865 cortical cytoskeleton organization 22.2222 6 no
GO:0031122 cytoplasmic microtubule organization 22.2222 4 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0031532 actin cytoskeleton reorganization 22.2222 4 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0032535 regulation of cellular component size 22.2222 4 no
GO:0032872 regulation of stress-activated MAPK cascade 22.2222 6 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 22.2222 4 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0048015 phosphatidylinositol-mediated signaling 22.2222 5 no
GO:0048017 inositol lipid-mediated signaling 22.2222 4 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0048639 positive regulation of developmental growth 22.2222 5 no
GO:0051017 actin filament bundle assembly 22.2222 5 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0061572 actin filament bundle organization 22.2222 6 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 22.2222 5 no
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0140694 non-membrane-bounded organelle assembly 22.2222 6 no
GO:1902115 regulation of organelle assembly 22.2222 5 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 22.2222 8 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:0002082 regulation of oxidative phosphorylation 22.2222 8 no
GO:0006417 regulation of translation 22.2222 6 no
GO:0006508 proteolysis 22.2222 4 no
GO:0010608 post-transcriptional regulation of gene expression 22.2222 6 no
GO:0016579 protein deubiquitination 22.2222 6 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0034248 regulation of cellular amide metabolic process 22.2222 5 no
GO:0043457 regulation of cellular respiration 22.2222 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 22.2222 5 no
GO:0070536 protein K63-linked deubiquitination 22.2222 7 no
GO:0070646 protein modification by small protein removal 22.2222 5 no
GO:0070647 protein modification by small protein conjugation or removal 22.2222 5 no
GO:0072521 purine-containing compound metabolic process 22.2222 4 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:1903715 regulation of aerobic respiration 22.2222 7 no
GO:0002685 regulation of leukocyte migration 22.2222 4 no
GO:0009743 response to carbohydrate 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010564 regulation of cell cycle process 22.2222 5 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0030336 negative regulation of cell migration 22.2222 6 no
GO:0030855 epithelial cell differentiation 22.2222 4 no
GO:0030859 polarized epithelial cell differentiation 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0032990 cell part morphogenesis 22.2222 4 no
GO:0033993 response to lipid 22.2222 4 no
GO:0034284 response to monosaccharide 22.2222 5 no
GO:0040013 negative regulation of locomotion 22.2222 4 no
GO:0045471 response to ethanol 22.2222 5 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045787 positive regulation of cell cycle 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0048812 neuron projection morphogenesis 22.2222 7 no
GO:0048858 cell projection morphogenesis 22.2222 5 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0071396 cellular response to lipid 22.2222 5 no
GO:0071675 regulation of mononuclear cell migration 22.2222 5 no
GO:0090068 positive regulation of cell cycle process 22.2222 6 no
GO:0097305 response to alcohol 22.2222 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 6 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:2000146 negative regulation of cell motility 22.2222 5 no
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0043434 response to peptide hormone 22.2222 4 no
GO:0071375 cellular response to peptide hormone stimulus 22.2222 5 no
GO:1901652 response to peptide 22.2222 4 no
GO:1901653 cellular response to peptide 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0006644 phospholipid metabolic process 22.2222 4 yes
GO:0006650 glycerophospholipid metabolic process 22.2222 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 22.2222 5 yes
GO:0010629 negative regulation of gene expression 22.2222 6 yes
GO:0014074 response to purine-containing compound 22.2222 5 yes
GO:0030100 regulation of endocytosis 22.2222 5 yes
GO:0046486 glycerolipid metabolic process 22.2222 4 yes
GO:0046683 response to organophosphorus 22.2222 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
HAVR2_HUMAN [view interactions] High throughput no no
TOR1A_HUMAN [view interactions] High throughput no yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
NT2NC_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
KDM5B_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B3_HUMAN [view interactions] High throughput no yes
EMIL1_HUMAN [view interactions] High throughput no no
EHD1_HUMAN [view entry] [view interactions] High throughput yes no
KAT1_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
IF4H_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes
PLD1_HUMAN [view interactions] Computational no no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
PLD2_HUMAN [view interactions] Computational no yes