Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DGKQ_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed, PubMed, PubMed). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed, PubMed, PubMed). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor . Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DGKQ_HUMAN
GO:0043168 anion binding 75.0000 4 yes
GO:0017076 purine nucleotide binding 62.5000 5 yes
GO:0032555 purine ribonucleotide binding 62.5000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 62.5000 4 yes
GO:0043169 cation binding 62.5000 4 yes
GO:0046872 metal ion binding 62.5000 5 yes
GO:0000166 nucleotide binding 62.5000 4 yes
GO:0005525 GTP binding 50.0000 5 no
GO:0019001 guanyl nucleotide binding 50.0000 6 no
GO:0032561 guanyl ribonucleotide binding 50.0000 5 no
GO:0045296 cadherin binding 50.0000 4 no
GO:0019900 kinase binding 37.5000 4 yes
GO:0030554 adenyl nucleotide binding 37.5000 6 yes
GO:0032559 adenyl ribonucleotide binding 37.5000 5 yes
GO:0005524 ATP binding 37.5000 5 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017022 myosin binding 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005509 calcium ion binding 25.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in DGKQ_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0051246 regulation of protein metabolic process 75.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0022607 cellular component assembly 62.5000 4 no
GO:0006996 organelle organization 62.5000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0060627 regulation of vesicle-mediated transport 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0072657 protein localization to membrane 50.0000 4 no
GO:0072659 protein localization to plasma membrane 50.0000 5 no
GO:1990778 protein localization to cell periphery 50.0000 5 no
GO:0070925 organelle assembly 50.0000 5 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 yes
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 yes
GO:0006355 regulation of DNA-templated transcription 37.5000 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 37.5000 8 yes
GO:0009890 negative regulation of biosynthetic process 37.5000 5 yes
GO:0009892 negative regulation of metabolic process 37.5000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 yes
GO:0010243 response to organonitrogen compound 37.5000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 yes
GO:0010646 regulation of cell communication 37.5000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 yes
GO:0019220 regulation of phosphate metabolic process 37.5000 6 yes
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 yes
GO:0031399 regulation of protein modification process 37.5000 6 yes
GO:0031401 positive regulation of protein modification process 37.5000 7 yes
GO:0036211 protein modification process 37.5000 4 yes
GO:0042325 regulation of phosphorylation 37.5000 7 yes
GO:0042327 positive regulation of phosphorylation 37.5000 8 yes
GO:0043412 macromolecule modification 37.5000 4 yes
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 yes
GO:0048523 negative regulation of cellular process 37.5000 4 yes
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 yes
GO:0051252 regulation of RNA metabolic process 37.5000 5 yes
GO:1902531 regulation of intracellular signal transduction 37.5000 5 yes
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 yes
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0051259 protein complex oligomerization 37.5000 6 no
GO:0051260 protein homooligomerization 37.5000 7 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:1901701 cellular response to oxygen-containing compound 37.5000 4 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0051094 positive regulation of developmental process 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0030031 cell projection assembly 37.5000 5 no
GO:0098657 import into cell 37.5000 4 no
GO:0120031 plasma membrane bounded cell projection assembly 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 yes
GO:0010628 positive regulation of gene expression 25.0000 7 yes
GO:0010629 negative regulation of gene expression 25.0000 7 yes
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0014074 response to purine-containing compound 25.0000 5 yes
GO:0030100 regulation of endocytosis 25.0000 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 yes
GO:0046683 response to organophosphorus 25.0000 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 yes
GO:0051591 response to cAMP 25.0000 4 yes
GO:0141124 intracellular signaling cassette 25.0000 4 yes
GO:0002082 regulation of oxidative phosphorylation 25.0000 8 no
GO:0016579 protein deubiquitination 25.0000 8 no
GO:0034097 response to cytokine 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043457 regulation of cellular respiration 25.0000 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 25.0000 5 no
GO:0043687 post-translational protein modification 25.0000 5 no
GO:0070536 protein K63-linked deubiquitination 25.0000 9 no
GO:0070646 protein modification by small protein removal 25.0000 7 no
GO:0070647 protein modification by small protein conjugation or removal 25.0000 6 no
GO:1901565 organonitrogen compound catabolic process 25.0000 4 no
GO:1903715 regulation of aerobic respiration 25.0000 7 no
GO:0015031 protein transport 25.0000 4 no
GO:0030855 epithelial cell differentiation 25.0000 4 no
GO:0030859 polarized epithelial cell differentiation 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031122 cytoplasmic microtubule organization 25.0000 4 no
GO:0032535 regulation of cellular component size 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051017 actin filament bundle assembly 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0061572 actin filament bundle organization 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:0140694 non-membrane-bounded organelle assembly 25.0000 6 no
GO:1902115 regulation of organelle assembly 25.0000 5 no
GO:0032456 endocytic recycling 25.0000 4 no
GO:0044782 cilium organization 25.0000 5 no
GO:0060271 cilium assembly 25.0000 6 no
GO:0071363 cellular response to growth factor stimulus 25.0000 4 no
GO:0032386 regulation of intracellular transport 25.0000 5 no
GO:0032388 positive regulation of intracellular transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
HAVR2_HUMAN [view interactions] High throughput no no
TOR1A_HUMAN [view interactions] High throughput no yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
NT2NC_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
KDM5B_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B3_HUMAN [view interactions] High throughput no yes
EMIL1_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
EHD1_HUMAN [view entry] [view interactions] High throughput yes no
KAT1_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
IF4H_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes