Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TM40L_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Potential channel-forming protein implicated in import of protein precursors into mitochondria. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TM40L_HUMAN
GO:0015267 channel activity 33.3333 4 yes
GO:0015288 porin activity 33.3333 6 yes
GO:0022829 wide pore channel activity 33.3333 5 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0005216 ion channel activity 25.0000 4 no
GO:0005244 voltage-gated ion channel activity 25.0000 4 no
GO:0005253 anion channel activity 25.0000 5 no
GO:0008308 voltage-gated anion channel activity 25.0000 5 no
GO:0008509 anion transmembrane transporter activity 25.0000 4 no
GO:0015103 inorganic anion transmembrane transporter activity 25.0000 4 no
GO:0022832 voltage-gated channel activity 25.0000 6 no
GO:0022836 gated channel activity 25.0000 5 no
GO:0005048 signal sequence binding 16.6667 4 yes
GO:0030943 mitochondrion targeting sequence binding 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TM40L_HUMAN
GO:0071702 organic substance transport 58.3333 4 yes
GO:0071705 nitrogen compound transport 58.3333 4 yes
GO:0008104 protein localization 50.0000 4 yes
GO:0015031 protein transport 50.0000 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0006886 intracellular protein transport 41.6667 4 yes
GO:0007005 mitochondrion organization 41.6667 5 no
GO:0006839 mitochondrial transport 33.3333 4 yes
GO:0033365 protein localization to organelle 33.3333 5 yes
GO:0070585 protein localization to mitochondrion 33.3333 6 yes
GO:0072594 establishment of protein localization to organelle 33.3333 4 yes
GO:0072655 establishment of protein localization to mitochondrion 33.3333 5 yes
GO:0007006 mitochondrial membrane organization 33.3333 5 no
GO:0061024 membrane organization 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0006811 ion transport 25.0000 4 yes
GO:0030150 protein import into mitochondrial matrix 25.0000 4 yes
GO:0044743 protein transmembrane import into intracellular organelle 25.0000 4 yes
GO:0065002 intracellular protein transmembrane transport 25.0000 4 yes
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TOM22_HUMAN [view interactions] High throughput no yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
KFA_HUMAN [view interactions] High throughput no no
TOM7_HUMAN [view interactions] High throughput no no
TOM6_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] Computational yes yes
TOM70_HUMAN [view interactions] Computational no yes
TI17B_HUMAN [view interactions] Computational no no
TOM20_HUMAN [view entry] [view interactions] Computational yes yes
VDAC1_HUMAN [view entry] [view interactions] Computational yes yes
VDAC3_HUMAN [view entry] [view interactions] Computational yes yes
MTX1_HUMAN [view entry] [view interactions] Computational yes yes
TO20L_HUMAN [view interactions] Computational no no
TI17A_HUMAN [view interactions] Computational no yes
TOM40_HUMAN [view interactions] Computational no yes
SODC_HUMAN [view interactions] Computational no yes
SAM50_HUMAN [view entry] [view interactions] Computational yes yes
TIM50_HUMAN [view entry] [view interactions] Computational yes yes
VDAC2_HUMAN [view entry] [view interactions] Computational yes yes
MTX3_HUMAN [view interactions] Computational no yes
RM12_HUMAN [view interactions] Computational no yes