5HT3B_HUMAN
Evidence for PS localization
Functions
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT3B_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 60.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 60.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 60.0000 | 7 | yes |
| GO:0015267 | channel activity | 60.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 60.0000 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 60.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 60.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 60.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 60.0000 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 60.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 60.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 60.0000 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 40.0000 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 40.0000 | 4 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 40.0000 | 7 | yes |
| GO:0022850 | serotonin-gated monoatomic cation channel activity | 40.0000 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 40.0000 | 6 | yes |
| GO:0099589 | serotonin receptor activity | 40.0000 | 4 | yes |
| GO:0043168 | anion binding | 40.0000 | 4 | no |
| GO:0043169 | cation binding | 40.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT3B_HUMAN |
|---|---|---|---|---|
| GO:0098662 | inorganic cation transmembrane transport | 40.0000 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 40.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5HT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXPE3_HUMAN | [view interactions] | High throughput | no | no |
| GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PXYP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC24_HUMAN | [view interactions] | High throughput | no | yes |
| SL9A1_HUMAN | [view interactions] | High throughput | no | no |
| RNAS7_HUMAN | [view interactions] | High throughput | no | no |
| IPRI_HUMAN | [view interactions] | High throughput | no | no |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| CC033_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB9_HUMAN | [view interactions] | High throughput | no | yes |
| S15A4_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |