S27A1_HUMAN
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism . Probably involved in fatty acid transport across the blood barrier (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in S27A1_HUMAN |
---|---|---|---|---|
GO:0008028 | monocarboxylic acid transmembrane transporter activity | 33.3333 | 5 | yes |
GO:0008509 | anion transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0008514 | organic anion transmembrane transporter activity | 33.3333 | 5 | yes |
GO:0016405 | CoA-ligase activity | 33.3333 | 4 | yes |
GO:0016878 | acid-thiol ligase activity | 33.3333 | 4 | yes |
GO:0046943 | carboxylic acid transmembrane transporter activity | 33.3333 | 4 | yes |
GO:0047676 | arachidonate-CoA ligase activity | 33.3333 | 4 | yes |
GO:0090434 | oleoyl-CoA ligase activity | 33.3333 | 4 | yes |
GO:1901480 | oleate transmembrane transporter activity | 33.3333 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in S27A1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0006811 | ion transport | 50.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
GO:0046323 | glucose import | 33.3333 | 7 | yes |
GO:0046942 | carboxylic acid transport | 33.3333 | 6 | yes |
GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
GO:0098657 | import into cell | 33.3333 | 4 | yes |
GO:0140354 | lipid import into cell | 33.3333 | 5 | yes |
GO:0150104 | transport across blood-brain barrier | 33.3333 | 5 | yes |
GO:1904659 | glucose transmembrane transport | 33.3333 | 6 | yes |
GO:1990379 | lipid transport across blood-brain barrier | 33.3333 | 6 | yes |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
GO:0043087 | regulation of GTPase activity | 33.3333 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | no |
GO:0001579 | medium-chain fatty acid transport | 33.3333 | 6 | yes |
GO:0003018 | vascular process in circulatory system | 33.3333 | 4 | yes |
GO:0006820 | anion transport | 33.3333 | 5 | yes |
GO:0006869 | lipid transport | 33.3333 | 5 | yes |
GO:0008643 | carbohydrate transport | 33.3333 | 5 | yes |
GO:0008645 | hexose transmembrane transport | 33.3333 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 33.3333 | 5 | yes |
GO:0010232 | vascular transport | 33.3333 | 4 | yes |
GO:0015711 | organic anion transport | 33.3333 | 5 | yes |
GO:0015718 | monocarboxylic acid transport | 33.3333 | 7 | yes |
GO:0015749 | monosaccharide transmembrane transport | 33.3333 | 4 | yes |
GO:0015849 | organic acid transport | 33.3333 | 5 | yes |
GO:0015908 | fatty acid transport | 33.3333 | 6 | yes |
GO:0015909 | long-chain fatty acid transport | 33.3333 | 7 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 33.3333 | 6 | yes |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | yes |
GO:0044381 | glucose import in response to insulin stimulus | 33.3333 | 8 | yes |
GO:0044539 | long-chain fatty acid import into cell | 33.3333 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RPE65_HUMAN | [view interactions] | Low throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
DGAT2_HUMAN | [view interactions] | High throughput | no | no |
SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
S22A9_HUMAN | [view interactions] | High throughput | no | no |
ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TSN15_HUMAN | [view interactions] | High throughput | no | yes |
PIGH_HUMAN | [view interactions] | High throughput | no | yes |
S39A4_HUMAN | [view interactions] | High throughput | no | no |
ITM2C_HUMAN | [view interactions] | High throughput | no | no |
ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
CAH6_HUMAN | [view interactions] | High throughput | no | no |
CA210_HUMAN | [view interactions] | High throughput | no | yes |
LRAD1_HUMAN | [view interactions] | High throughput | no | no |
PEX19_HUMAN | [view interactions] | High throughput | no | yes |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
CD79A_HUMAN | [view interactions] | High throughput | no | no |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCOA2_HUMAN | [view interactions] | Computational | no | no |
PPARA_HUMAN | [view interactions] | Computational | no | yes |
ACSL1_HUMAN | [view interactions] | Computational | no | no |
NCOA1_HUMAN | [view interactions] | Computational | no | yes |
TGS1_HUMAN | [view interactions] | Computational | no | yes |
TBL1R_HUMAN | [view interactions] | Computational | no | yes |
CBP_HUMAN | [view interactions] | Computational | no | yes |
CARM1_HUMAN | [view interactions] | Computational | no | yes |
CHD9_HUMAN | [view interactions] | Computational | no | yes |
MED1_HUMAN | [view interactions] | Computational | no | no |
SMRD3_HUMAN | [view interactions] | Computational | no | no |
RXRA_HUMAN | [view interactions] | Computational | no | yes |
NCOA6_HUMAN | [view interactions] | Computational | no | yes |
FABPL_HUMAN | [view interactions] | Computational | no | no |
HELZ2_HUMAN | [view interactions] | Computational | no | no |
S27A4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |