S27A1_HUMAN
Evidence for PS localization
Functions
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism . Probably involved in fatty acid transport across the blood barrier (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S27A1_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 33.3333 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | yes |
| GO:0098657 | import into cell | 33.3333 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RPE65_HUMAN | [view interactions] | Low throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| DGAT2_HUMAN | [view interactions] | High throughput | no | no |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| ITM2C_HUMAN | [view interactions] | High throughput | no | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| CAH6_HUMAN | [view interactions] | High throughput | no | no |
| CA210_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |