Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SH2D5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SH2D5_HUMAN
GO:0000166 nucleotide binding 40.0000 4 no
GO:0004713 protein tyrosine kinase activity 40.0000 4 no
GO:0005524 ATP binding 40.0000 5 no
GO:0016301 kinase activity 40.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 40.0000 4 no
GO:0017076 purine nucleotide binding 40.0000 5 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 40.0000 5 no
GO:0030554 adenyl nucleotide binding 40.0000 6 no
GO:0030971 receptor tyrosine kinase binding 40.0000 4 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0043168 anion binding 40.0000 4 no
GO:1990782 protein tyrosine kinase binding 40.0000 6 no
GO:0030695 GTPase regulator activity 40.0000 4 no
GO:0003723 RNA binding 40.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SH2D5_HUMAN
GO:0009966 regulation of signal transduction 80.0000 4 no
GO:0010646 regulation of cell communication 80.0000 4 no
GO:0031323 regulation of cellular metabolic process 80.0000 4 no
GO:0048522 positive regulation of cellular process 80.0000 4 no
GO:0051128 regulation of cellular component organization 80.0000 4 no
GO:1902531 regulation of intracellular signal transduction 80.0000 5 no
GO:0008104 protein localization 60.0000 4 no
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 60.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 no
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 60.0000 6 no
GO:0141124 intracellular signaling cassette 60.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0007010 cytoskeleton organization 40.0000 5 no
GO:0007264 small GTPase-mediated signal transduction 40.0000 5 no
GO:0030334 regulation of cell migration 40.0000 5 no
GO:0043087 regulation of GTPase activity 40.0000 5 no
GO:0050776 regulation of immune response 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051336 regulation of hydrolase activity 40.0000 4 no
GO:0051726 regulation of cell cycle 40.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0098657 import into cell 40.0000 4 no
GO:2000145 regulation of cell motility 40.0000 4 no
GO:2000377 regulation of reactive oxygen species metabolic process 40.0000 5 no
GO:0008064 regulation of actin polymerization or depolymerization 40.0000 6 no
GO:0030832 regulation of actin filament length 40.0000 5 no
GO:0030833 regulation of actin filament polymerization 40.0000 7 no
GO:0032271 regulation of protein polymerization 40.0000 6 no
GO:0032535 regulation of cellular component size 40.0000 4 no
GO:0032956 regulation of actin cytoskeleton organization 40.0000 5 no
GO:0032970 regulation of actin filament-based process 40.0000 4 no
GO:0033043 regulation of organelle organization 40.0000 5 no
GO:0043254 regulation of protein-containing complex assembly 40.0000 5 no
GO:0044087 regulation of cellular component biogenesis 40.0000 4 no
GO:0051493 regulation of cytoskeleton organization 40.0000 6 no
GO:0110053 regulation of actin filament organization 40.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 40.0000 5 no
GO:0002683 negative regulation of immune system process 40.0000 4 no
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 no
GO:0007162 negative regulation of cell adhesion 40.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 40.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 40.0000 5 no
GO:0007173 epidermal growth factor receptor signaling pathway 40.0000 7 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010468 regulation of gene expression 40.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0010628 positive regulation of gene expression 40.0000 7 no
GO:0014044 Schwann cell development 40.0000 5 no
GO:0016310 phosphorylation 40.0000 5 no
GO:0021782 glial cell development 40.0000 4 no
GO:0022407 regulation of cell-cell adhesion 40.0000 5 no
GO:0022408 negative regulation of cell-cell adhesion 40.0000 6 no
GO:0030155 regulation of cell adhesion 40.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0034330 cell junction organization 40.0000 4 no
GO:0035023 regulation of Rho protein signal transduction 40.0000 7 no
GO:0036211 protein modification process 40.0000 4 no
GO:0038127 ERBB signaling pathway 40.0000 6 no
GO:0042552 myelination 40.0000 4 no
GO:0043085 positive regulation of catalytic activity 40.0000 4 no
GO:0043408 regulation of MAPK cascade 40.0000 6 no
GO:0043412 macromolecule modification 40.0000 4 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0051093 negative regulation of developmental process 40.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 40.0000 4 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0071363 cellular response to growth factor stimulus 40.0000 4 no
GO:0072657 protein localization to membrane 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:1903829 positive regulation of protein localization 40.0000 5 no
GO:1990778 protein localization to cell periphery 40.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
PDZ1P_HUMAN [view interactions] High throughput no no
NHRF3_HUMAN [view interactions] High throughput no no
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no