Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MDGA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Required for radial migration of cortical neurons in the superficial layer of the neocortex . Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

No data found.

Biological process

Term Name % Distance from top the of the tree Annotated in MDGA1_HUMAN
GO:0051128 regulation of cellular component organization 100.0000 4 yes
GO:0050807 regulation of synapse organization 80.0000 5 yes
GO:0001764 neuron migration 60.0000 4 yes
GO:0030182 neuron differentiation 60.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 60.0000 4 yes
GO:0051963 regulation of synapse assembly 60.0000 6 yes
GO:0099174 regulation of presynapse organization 60.0000 6 yes
GO:1901888 regulation of cell junction assembly 60.0000 5 yes
GO:1905606 regulation of presynapse assembly 60.0000 7 yes
GO:0008104 protein localization 60.0000 4 no
GO:0010646 regulation of cell communication 60.0000 4 no
GO:0034330 cell junction organization 60.0000 4 no
GO:0043113 receptor clustering 60.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 60.0000 5 no
GO:0050808 synapse organization 60.0000 5 no
GO:0051960 regulation of nervous system development 60.0000 5 no
GO:0072657 protein localization to membrane 60.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 60.0000 4 no
GO:2000026 regulation of multicellular organismal development 60.0000 4 no
GO:0007399 nervous system development 40.0000 4 yes
GO:0007420 brain development 40.0000 4 yes
GO:0021515 cell differentiation in spinal cord 40.0000 4 yes
GO:0021527 spinal cord association neuron differentiation 40.0000 5 yes
GO:0021795 cerebral cortex cell migration 40.0000 6 yes
GO:0021799 cerebral cortex radially oriented cell migration 40.0000 7 yes
GO:0021885 forebrain cell migration 40.0000 4 yes
GO:0021953 central nervous system neuron differentiation 40.0000 5 yes
GO:0022029 telencephalon cell migration 40.0000 5 yes
GO:0022407 regulation of cell-cell adhesion 40.0000 5 yes
GO:0030155 regulation of cell adhesion 40.0000 4 yes
GO:0099179 regulation of synaptic membrane adhesion 40.0000 6 yes
GO:0007268 chemical synaptic transmission 40.0000 7 no
GO:0007416 synapse assembly 40.0000 6 no
GO:0007600 sensory perception 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0019233 sensory perception of pain 40.0000 5 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0034329 cell junction assembly 40.0000 5 no
GO:0034331 cell junction maintenance 40.0000 5 no
GO:0035418 protein localization to synapse 40.0000 6 no
GO:0043954 cellular component maintenance 40.0000 4 no
GO:0048488 synaptic vesicle endocytosis 40.0000 5 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0051046 regulation of secretion 40.0000 5 no
GO:0051047 positive regulation of secretion 40.0000 5 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051223 regulation of protein transport 40.0000 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 40.0000 6 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0070201 regulation of establishment of protein localization 40.0000 6 no
GO:0098657 import into cell 40.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 40.0000 6 no
GO:0099536 synaptic signaling 40.0000 4 no
GO:0099537 trans-synaptic signaling 40.0000 5 no
GO:0140238 presynaptic endocytosis 40.0000 4 no
GO:1902414 protein localization to cell junction 40.0000 5 no
GO:1903530 regulation of secretion by cell 40.0000 4 no
GO:1903532 positive regulation of secretion by cell 40.0000 5 no
GO:1903829 positive regulation of protein localization 40.0000 5 no
GO:1904951 positive regulation of establishment of protein localization 40.0000 6 no
GO:1905475 regulation of protein localization to membrane 40.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 40.0000 6 no
GO:0006915 apoptotic process 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0007409 axonogenesis 40.0000 6 no
GO:0007612 learning 40.0000 4 no
GO:0008306 associative learning 40.0000 5 no
GO:0008542 visual learning 40.0000 4 no
GO:0009416 response to light stimulus 40.0000 4 no
GO:0010721 negative regulation of cell development 40.0000 6 no
GO:0010975 regulation of neuron projection development 40.0000 7 no
GO:0010977 negative regulation of neuron projection development 40.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 40.0000 4 no
GO:0030030 cell projection organization 40.0000 4 no
GO:0031175 neuron projection development 40.0000 6 no
GO:0031344 regulation of cell projection organization 40.0000 5 no
GO:0031345 negative regulation of cell projection organization 40.0000 6 no
GO:0042981 regulation of apoptotic process 40.0000 5 no
GO:0043067 regulation of programmed cell death 40.0000 4 no
GO:0043523 regulation of neuron apoptotic process 40.0000 6 no
GO:0045595 regulation of cell differentiation 40.0000 4 no
GO:0045596 negative regulation of cell differentiation 40.0000 5 no
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0048812 neuron projection morphogenesis 40.0000 5 no
GO:0050767 regulation of neurogenesis 40.0000 6 no
GO:0050768 negative regulation of neurogenesis 40.0000 6 no
GO:0050770 regulation of axonogenesis 40.0000 5 no
GO:0050771 negative regulation of axonogenesis 40.0000 6 no
GO:0050890 cognition 40.0000 4 no
GO:0051093 negative regulation of developmental process 40.0000 4 no
GO:0051129 negative regulation of cellular component organization 40.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 40.0000 4 no
GO:0051402 neuron apoptotic process 40.0000 5 no
GO:0051961 negative regulation of nervous system development 40.0000 5 no
GO:0060284 regulation of cell development 40.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 40.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 40.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
MDGA1_HUMAN [view entry] [view interactions] Low throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
LNX2_HUMAN [view interactions] High throughput no yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes