Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PCDH1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in cell-cell interaction processes and in cell adhesion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PCDH1_HUMAN
GO:0043169 cation binding 44.4444 4 yes
GO:0046872 metal ion binding 44.4444 5 yes
GO:0005509 calcium ion binding 33.3333 6 yes
GO:0000166 nucleotide binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0005216 monoatomic ion channel activity 22.2222 4 no
GO:0005261 monoatomic cation channel activity 22.2222 5 no
GO:0005262 calcium channel activity 22.2222 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 22.2222 4 no
GO:0015085 calcium ion transmembrane transporter activity 22.2222 6 no
GO:0015267 channel activity 22.2222 4 no
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 no
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0005525 GTP binding 22.2222 5 no
GO:0019001 guanyl nucleotide binding 22.2222 6 no
GO:0019003 GDP binding 22.2222 5 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PCDH1_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031344 regulation of cell projection organization 44.4444 5 no
GO:0034329 cell junction assembly 44.4444 5 no
GO:0034330 cell junction organization 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 44.4444 6 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 yes
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0007416 synapse assembly 33.3333 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0050808 synapse organization 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 22.2222 5 yes
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0098657 import into cell 22.2222 4 no
GO:0001558 regulation of cell growth 22.2222 4 no
GO:0010721 negative regulation of cell development 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0010977 negative regulation of neuron projection development 22.2222 7 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0030308 negative regulation of cell growth 22.2222 5 no
GO:0030516 regulation of axon extension 22.2222 5 no
GO:0030517 negative regulation of axon extension 22.2222 6 no
GO:0031345 negative regulation of cell projection organization 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0040013 negative regulation of locomotion 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045596 negative regulation of cell differentiation 22.2222 5 no
GO:0045926 negative regulation of growth 22.2222 4 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0048640 negative regulation of developmental growth 22.2222 5 no
GO:0050767 regulation of neurogenesis 22.2222 6 no
GO:0050768 negative regulation of neurogenesis 22.2222 6 no
GO:0050770 regulation of axonogenesis 22.2222 5 no
GO:0050771 negative regulation of axonogenesis 22.2222 6 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051960 regulation of nervous system development 22.2222 5 no
GO:0051961 negative regulation of nervous system development 22.2222 5 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0061387 regulation of extent of cell growth 22.2222 5 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0000165 MAPK cascade 22.2222 5 no
GO:0007264 small GTPase-mediated signal transduction 22.2222 5 no
GO:0007265 Ras protein signal transduction 22.2222 6 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0048812 neuron projection morphogenesis 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0060491 regulation of cell projection assembly 22.2222 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SMAD3_HUMAN [view interactions] High throughput no yes
MCAF1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPI2_HUMAN [view interactions] High throughput no yes
ABCA2_HUMAN [view interactions] High throughput no yes
TRIB1_HUMAN [view interactions] High throughput no no
C19L2_HUMAN [view interactions] High throughput no yes
TF3C3_HUMAN [view interactions] High throughput no no
ZNFX1_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
ALBU_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
VKOR1_HUMAN [view interactions] High throughput no yes
ACBP_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
RYK_HUMAN [view entry] [view interactions] High throughput yes no
CORT_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
CRLF1_HUMAN [view interactions] High throughput no no
SPSB2_HUMAN [view interactions] High throughput no no
ARL4D_HUMAN [view interactions] High throughput no no
SGCA_HUMAN [view interactions] High throughput no yes
FCGRN_HUMAN [view interactions] High throughput no yes
GPX7_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
PCDAB_HUMAN [view interactions] High throughput no no
MO2R1_HUMAN [view interactions] High throughput no no
PVR_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
PD1L2_HUMAN [view interactions] High throughput no yes
NXPH1_HUMAN [view interactions] High throughput no no
NXPH2_HUMAN [view interactions] High throughput no no
KI3L1_HUMAN [view interactions] High throughput no no
SDF2L_HUMAN [view interactions] High throughput no yes
BSSP4_HUMAN [view interactions] High throughput no no
IFNE_HUMAN [view interactions] High throughput no no
VSIG4_HUMAN [view interactions] High throughput no no
BY55_HUMAN [view interactions] High throughput no no
SRP14_HUMAN [view interactions] High throughput no no
IL20_HUMAN [view interactions] High throughput no no
ICAM2_HUMAN [view interactions] High throughput no no
PLPR2_HUMAN [view interactions] High throughput no yes
CD48_HUMAN [view interactions] High throughput no no
CD70_HUMAN [view interactions] High throughput no no
PCDG4_HUMAN [view interactions] High throughput no no
UPK2_HUMAN [view interactions] High throughput no no
LIRB4_HUMAN [view interactions] High throughput no no
ICOS_HUMAN [view interactions] High throughput no no
NXPH3_HUMAN [view interactions] High throughput no no
SIA8B_HUMAN [view interactions] High throughput no yes
PCDB7_HUMAN [view interactions] High throughput no yes
DKKL1_HUMAN [view interactions] High throughput no no
CADH8_HUMAN [view interactions] High throughput no no
CEA21_HUMAN [view interactions] High throughput no yes
CD4_HUMAN [view interactions] High throughput no no
FLRT1_HUMAN [view interactions] High throughput no no
CAD12_HUMAN [view interactions] High throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
RAE1E_HUMAN [view interactions] High throughput no no
MICA_HUMAN [view interactions] High throughput no no
SACA1_HUMAN [view interactions] High throughput no no
PCD20_HUMAN [view interactions] High throughput no no
IL1R2_HUMAN [view interactions] High throughput no no
TM11A_HUMAN [view interactions] High throughput no no
LRN4L_HUMAN [view interactions] High throughput no yes
FCGR1_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
MUC18_HUMAN [view interactions] High throughput no yes