Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004119 LIG_WRC_WIRS_1 LIG 1359 1364 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEO1_HUMAN
GO:0017076 purine nucleotide binding 46.1538 4 no
GO:0032555 purine ribonucleotide binding 46.1538 4 no
GO:0035639 purine ribonucleoside triphosphate binding 46.1538 4 no
GO:0003924 GTPase activity 38.4615 7 no
GO:0005525 GTP binding 38.4615 5 no
GO:0016462 pyrophosphatase activity 38.4615 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 38.4615 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 38.4615 6 no
GO:0019001 guanyl nucleotide binding 38.4615 5 no
GO:0019003 GDP binding 38.4615 4 no
GO:0032561 guanyl ribonucleotide binding 38.4615 5 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in NEO1_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0010646 regulation of cell communication 76.9231 4 yes
GO:0009966 regulation of signal transduction 69.2308 4 yes
GO:0048523 negative regulation of cellular process 61.5385 4 no
GO:0010647 positive regulation of cell communication 53.8462 5 yes
GO:0023056 positive regulation of signaling 53.8462 4 yes
GO:0048584 positive regulation of response to stimulus 53.8462 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:0008104 protein localization 53.8462 4 no
GO:0009967 positive regulation of signal transduction 46.1538 5 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0033043 regulation of organelle organization 46.1538 5 no
GO:0042127 regulation of cell population proliferation 46.1538 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0015031 protein transport 46.1538 4 no
GO:0071702 organic substance transport 46.1538 4 no
GO:0071705 nitrogen compound transport 46.1538 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0010941 regulation of cell death 38.4615 4 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0042981 regulation of apoptotic process 38.4615 6 no
GO:0043067 regulation of programmed cell death 38.4615 5 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0006886 intracellular protein transport 38.4615 4 no
GO:0006996 organelle organization 38.4615 4 no
GO:0016192 vesicle-mediated transport 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 5 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 no
GO:0009894 regulation of catabolic process 30.7692 4 no
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0043933 protein-containing complex organization 30.7692 4 no
GO:0044087 regulation of cellular component biogenesis 30.7692 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0017157 regulation of exocytosis 30.7692 5 no
GO:0045921 positive regulation of exocytosis 30.7692 6 no
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 no
GO:0051046 regulation of secretion 30.7692 5 no
GO:0051047 positive regulation of secretion 30.7692 5 no
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 no
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 no
GO:1903530 regulation of secretion by cell 30.7692 4 no
GO:1903532 positive regulation of secretion by cell 30.7692 5 no
GO:0007411 axon guidance 23.0769 8 yes
GO:0030030 cell projection organization 23.0769 4 yes
GO:0031175 neuron projection development 23.0769 6 yes
GO:0048878 chemical homeostasis 23.0769 4 yes
GO:0050801 ion homeostasis 23.0769 5 yes
GO:0055080 cation homeostasis 23.0769 6 yes
GO:0097485 neuron projection guidance 23.0769 7 yes
GO:0098771 inorganic ion homeostasis 23.0769 6 yes
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 yes
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0030334 regulation of cell migration 23.0769 5 no
GO:0030335 positive regulation of cell migration 23.0769 6 no
GO:0031329 regulation of cellular catabolic process 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0043066 negative regulation of apoptotic process 23.0769 7 no
GO:0043069 negative regulation of programmed cell death 23.0769 6 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0060548 negative regulation of cell death 23.0769 5 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:2000145 regulation of cell motility 23.0769 4 no
GO:2000147 positive regulation of cell motility 23.0769 5 no
GO:0007034 vacuolar transport 23.0769 4 no
GO:0007041 lysosomal transport 23.0769 5 no
GO:0007264 small GTPase mediated signal transduction 23.0769 4 no
GO:0007265 Ras protein signal transduction 23.0769 5 no
GO:0008333 endosome to lysosome transport 23.0769 5 no
GO:0010628 positive regulation of gene expression 23.0769 6 no
GO:0016050 vesicle organization 23.0769 5 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 23.0769 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051253 negative regulation of RNA metabolic process 23.0769 6 no
GO:0001764 neuron migration 15.3846 4 yes
GO:0030510 regulation of BMP signaling pathway 15.3846 5 yes
GO:0030513 positive regulation of BMP signaling pathway 15.3846 6 yes
GO:0055065 metal ion homeostasis 15.3846 7 yes
GO:0055072 iron ion homeostasis 15.3846 9 yes
GO:0055076 transition metal ion homeostasis 15.3846 8 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 15.3846 5 yes
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 15.3846 6 yes
GO:0090287 regulation of cellular response to growth factor stimulus 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO10_HUMAN [view interactions] Low throughput no no
RGMC_HUMAN [view interactions] Low throughput no no
BMP2_HUMAN [view interactions] Low throughput no no
NET4_HUMAN [view interactions] Low throughput no yes
NET1_HUMAN [view interactions] Low throughput no no
UNC5B_HUMAN [view interactions] Low throughput no yes
RGMB_HUMAN [view interactions] Low throughput no no
CAD15_HUMAN [view interactions] Low throughput no no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
NET3_HUMAN [view interactions] Low throughput no no
CDON_HUMAN [view interactions] Low throughput no no
NEO1_HUMAN [view entry] [view interactions] Low throughput yes yes
GDF5_HUMAN [view interactions] Low throughput no no
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
TITIN_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TNFA_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view interactions] High throughput no no
MFAP5_HUMAN [view interactions] High throughput no no
CTLA4_HUMAN [view interactions] High throughput no no
IGLL5_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
BMR1B_HUMAN [view interactions] Computational no no
BMR1A_HUMAN [view interactions] Computational no no
UNC5D_HUMAN [view interactions] Computational no no
DRAXI_HUMAN [view interactions] Computational no no
ARHGC_HUMAN [view interactions] Computational no yes
TMPS6_HUMAN [view interactions] Computational no no
ACVR1_HUMAN [view interactions] Computational no yes
UNC5A_HUMAN [view interactions] Computational no no
UNC5C_HUMAN [view interactions] Computational no no