Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004677 LIG_FERM_MyoX_1 LIG 1441 1459 -
ELMI004119 LIG_WRC_WIRS_1 LIG 1359 1364 -
ELMI004677 LIG_FERM_MyoX_1 LIG 1441 1459 -
ELMI004119 LIG_WRC_WIRS_1 LIG 1359 1364 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEO1_HUMAN
GO:0000166 nucleotide binding 53.3333 4 no
GO:0017076 purine nucleotide binding 53.3333 5 no
GO:0032555 purine ribonucleotide binding 53.3333 4 no
GO:0043168 anion binding 53.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 46.6667 4 no
GO:0003924 GTPase activity 33.3333 7 no
GO:0005525 GTP binding 33.3333 5 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0019001 guanyl nucleotide binding 33.3333 6 no
GO:0019003 GDP binding 33.3333 5 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0045296 cadherin binding 20.0000 4 yes
GO:0033612 receptor serine/threonine kinase binding 13.3333 4 yes
GO:0070696 transmembrane receptor protein serine/threonine kinase binding 13.3333 5 yes
GO:0070700 BMP receptor binding 13.3333 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEO1_HUMAN
GO:0048522 positive regulation of cellular process 86.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0008104 protein localization 60.0000 4 yes
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0010647 positive regulation of cell communication 53.3333 5 yes
GO:0023056 positive regulation of signaling 53.3333 4 yes
GO:0048584 positive regulation of response to stimulus 53.3333 4 yes
GO:0051128 regulation of cellular component organization 53.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 yes
GO:0009967 positive regulation of signal transduction 46.6667 5 yes
GO:0015031 protein transport 46.6667 4 yes
GO:0031323 regulation of cellular metabolic process 46.6667 4 yes
GO:0051049 regulation of transport 46.6667 4 yes
GO:0071702 organic substance transport 46.6667 4 yes
GO:0071705 nitrogen compound transport 46.6667 4 yes
GO:0080090 regulation of primary metabolic process 46.6667 4 yes
GO:0022607 cellular component assembly 46.6667 4 no
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0010468 regulation of gene expression 40.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 yes
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0031344 regulation of cell projection organization 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0007411 axon guidance 26.6667 8 yes
GO:0010975 regulation of neuron projection development 26.6667 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.6667 5 yes
GO:0030030 cell projection organization 26.6667 4 yes
GO:0031175 neuron projection development 26.6667 6 yes
GO:0032880 regulation of protein localization 26.6667 5 yes
GO:0051093 negative regulation of developmental process 26.6667 4 yes
GO:0051129 negative regulation of cellular component organization 26.6667 5 yes
GO:0051252 regulation of RNA metabolic process 26.6667 5 yes
GO:0060341 regulation of cellular localization 26.6667 4 yes
GO:0097485 neuron projection guidance 26.6667 7 yes
GO:0120036 plasma membrane bounded cell projection organization 26.6667 5 yes
GO:0141124 intracellular signaling cassette 26.6667 4 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0050804 modulation of chemical synaptic transmission 26.6667 5 no
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0099177 regulation of trans-synaptic signaling 26.6667 4 no
GO:0043933 protein-containing complex organization 26.6667 4 no
GO:0065003 protein-containing complex assembly 26.6667 5 no
GO:0009894 regulation of catabolic process 26.6667 4 no
GO:0051094 positive regulation of developmental process 26.6667 4 no
GO:0051240 positive regulation of multicellular organismal process 26.6667 4 no
GO:2000026 regulation of multicellular organismal development 26.6667 4 no
GO:0051246 regulation of protein metabolic process 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0006355 regulation of DNA-templated transcription 20.0000 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 20.0000 4 yes
GO:0010977 negative regulation of neuron projection development 20.0000 7 yes
GO:0030003 intracellular monoatomic cation homeostasis 20.0000 5 yes
GO:0031345 negative regulation of cell projection organization 20.0000 6 yes
GO:0032102 negative regulation of response to external stimulus 20.0000 5 yes
GO:0046903 secretion 20.0000 4 yes
GO:0050708 regulation of protein secretion 20.0000 5 yes
GO:0051048 negative regulation of secretion 20.0000 5 yes
GO:0051051 negative regulation of transport 20.0000 4 yes
GO:0051223 regulation of protein transport 20.0000 5 yes
GO:0055080 monoatomic cation homeostasis 20.0000 4 yes
GO:0070201 regulation of establishment of protein localization 20.0000 6 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:1903034 regulation of response to wounding 20.0000 5 yes
GO:1903531 negative regulation of secretion by cell 20.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 20.0000 6 yes
GO:0001764 neuron migration 13.3333 4 yes
GO:0006879 intracellular iron ion homeostasis 13.3333 4 yes
GO:0007520 myoblast fusion 13.3333 4 yes
GO:0009306 protein secretion 13.3333 4 yes
GO:0030510 regulation of BMP signaling pathway 13.3333 5 yes
GO:0030513 positive regulation of BMP signaling pathway 13.3333 6 yes
GO:0035592 establishment of protein localization to extracellular region 13.3333 4 yes
GO:0048679 regulation of axon regeneration 13.3333 5 yes
GO:0048681 negative regulation of axon regeneration 13.3333 6 yes
GO:0050709 negative regulation of protein secretion 13.3333 6 yes
GO:0051224 negative regulation of protein transport 13.3333 5 yes
GO:0060586 multicellular organismal-level iron ion homeostasis 13.3333 4 yes
GO:0070570 regulation of neuron projection regeneration 13.3333 4 yes
GO:0070571 negative regulation of neuron projection regeneration 13.3333 5 yes
GO:0071692 protein localization to extracellular region 13.3333 5 yes
GO:0080135 regulation of cellular response to stress 13.3333 4 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13.3333 5 yes
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13.3333 6 yes
GO:0090287 regulation of cellular response to growth factor stimulus 13.3333 4 yes
GO:1903035 negative regulation of response to wounding 13.3333 5 yes
GO:1903828 negative regulation of protein localization 13.3333 5 yes
GO:1904950 negative regulation of establishment of protein localization 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEO1_HUMAN [view entry] [view interactions] Low throughput yes yes
GDF5_HUMAN [view interactions] Low throughput no no
MYO10_HUMAN [view interactions] Low throughput no no
RGMC_HUMAN [view interactions] Low throughput no no
BMP2_HUMAN [view interactions] Low throughput no no
NET4_HUMAN [view interactions] Low throughput no yes
NET1_HUMAN [view interactions] Low throughput no no
UNC5B_HUMAN [view interactions] Low throughput no yes
RGMB_HUMAN [view interactions] Low throughput no no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD15_HUMAN [view interactions] Low throughput no no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
NET3_HUMAN [view interactions] Low throughput no no
CDON_HUMAN [view interactions] Low throughput no no
CBLN4_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARL14_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TITIN_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TNFA_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
MFAP5_HUMAN [view interactions] High throughput no no
CTLA4_HUMAN [view interactions] High throughput no no
IGLL5_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no