Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CADH4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CADH4_HUMAN
GO:0019900 kinase binding 66.6667 4 no
GO:0019901 protein kinase binding 66.6667 5 no
GO:0045296 cadherin binding 44.4444 4 yes
GO:0046872 metal ion binding 33.3333 4 yes
GO:0019902 phosphatase binding 33.3333 4 no
GO:0019903 protein phosphatase binding 33.3333 5 no
GO:0005509 calcium ion binding 22.2222 5 yes
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0003677 DNA binding 22.2222 4 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CADH4_HUMAN
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0048523 negative regulation of cellular process 88.8889 4 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0009966 regulation of signal transduction 66.6667 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0022607 cellular component assembly 66.6667 4 no
GO:0032880 regulation of protein localization 66.6667 5 no
GO:0060341 regulation of cellular localization 66.6667 4 no
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 no
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 55.5556 5 no
GO:0022603 regulation of anatomical structure morphogenesis 55.5556 4 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0048584 positive regulation of response to stimulus 55.5556 4 no
GO:0051049 regulation of transport 55.5556 4 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043549 regulation of kinase activity 44.4444 5 no
GO:0045859 regulation of protein kinase activity 44.4444 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:1903829 positive regulation of protein localization 44.4444 5 no
GO:0006355 regulation of DNA-templated transcription 44.4444 6 no
GO:0006357 regulation of transcription by RNA polymerase II 44.4444 7 no
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 5 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0051252 regulation of RNA metabolic process 44.4444 5 no
GO:1903506 regulation of nucleic acid-templated transcription 44.4444 7 no
GO:2001141 regulation of RNA biosynthetic process 44.4444 6 no
GO:0031344 regulation of cell projection organization 44.4444 5 yes
GO:0009968 negative regulation of signal transduction 44.4444 5 no
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:0008104 protein localization 44.4444 4 no
GO:0009967 positive regulation of signal transduction 44.4444 5 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:1990778 protein localization to cell periphery 33.3333 5 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0006469 negative regulation of protein kinase activity 33.3333 7 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0033673 negative regulation of kinase activity 33.3333 6 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 33.3333 8 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051348 negative regulation of transferase activity 33.3333 5 no
GO:0061097 regulation of protein tyrosine kinase activity 33.3333 7 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:0010975 regulation of neuron projection development 33.3333 7 yes
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:0051130 positive regulation of cellular component organization 33.3333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 yes
GO:0007043 cell-cell junction assembly 33.3333 6 no
GO:0007420 brain development 33.3333 4 no
GO:0030111 regulation of Wnt signaling pathway 33.3333 5 no
GO:0034329 cell junction assembly 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0045216 cell-cell junction organization 33.3333 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 33.3333 6 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006887 exocytosis 22.2222 4 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0046903 secretion 22.2222 4 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0061099 negative regulation of protein tyrosine kinase activity 22.2222 8 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0006996 organelle organization 22.2222 4 no
GO:0016050 vesicle organization 22.2222 5 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:1900180 regulation of protein localization to nucleus 22.2222 6 no
GO:1900182 positive regulation of protein localization to nucleus 22.2222 6 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0022411 cellular component disassembly 22.2222 4 no
GO:0032446 protein modification by small protein conjugation 22.2222 6 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043405 regulation of MAP kinase activity 22.2222 8 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0070647 protein modification by small protein conjugation or removal 22.2222 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0001558 regulation of cell growth 22.2222 4 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 22.2222 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 22.2222 5 yes
GO:0030030 cell projection organization 22.2222 4 yes
GO:0031175 neuron projection development 22.2222 6 yes
GO:0031346 positive regulation of cell projection organization 22.2222 6 yes
GO:0045595 regulation of cell differentiation 22.2222 4 yes
GO:0050770 regulation of axonogenesis 22.2222 5 yes
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 22.2222 4 yes
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 yes
GO:2000026 regulation of multicellular organismal development 22.2222 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 22.2222 6 no
GO:0044331 cell-cell adhesion mediated by cadherin 22.2222 4 no
GO:0090090 negative regulation of canonical Wnt signaling pathway 22.2222 7 no
GO:0030855 epithelial cell differentiation 22.2222 4 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0050982 detection of mechanical stimulus 22.2222 4 no
GO:0072659 protein localization to plasma membrane 22.2222 5 no
GO:0099175 regulation of postsynapse organization 22.2222 6 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRM_HUMAN [view interactions] Low throughput no yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CK5P3_HUMAN [view entry] [view interactions] Low throughput yes yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
MP2K6_HUMAN [view interactions] Computational no yes
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no