Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CADH4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CADH4_HUMAN
GO:0019900 kinase binding 62.5000 4 no
GO:0019901 protein kinase binding 50.0000 5 no
GO:0043169 cation binding 37.5000 4 yes
GO:0045296 cadherin binding 37.5000 4 yes
GO:0046872 metal ion binding 37.5000 5 yes
GO:0019902 phosphatase binding 37.5000 4 no
GO:0019903 protein phosphatase binding 37.5000 5 no
GO:0003723 RNA binding 37.5000 4 no
GO:0005509 calcium ion binding 25.0000 6 yes
GO:0001221 transcription coregulator binding 25.0000 4 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25.0000 5 no
GO:0140297 DNA-binding transcription factor binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CADH4_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 no
GO:0080090 regulation of primary metabolic process 75.0000 4 no
GO:0022607 cellular component assembly 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0048584 positive regulation of response to stimulus 62.5000 4 no
GO:0051246 regulation of protein metabolic process 62.5000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 62.5000 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0009892 negative regulation of metabolic process 62.5000 4 no
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 62.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0031399 regulation of protein modification process 62.5000 6 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0051338 regulation of transferase activity 50.0000 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 7 no
GO:0006357 regulation of transcription by RNA polymerase II 50.0000 8 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0036211 protein modification process 37.5000 4 no
GO:0043408 regulation of MAPK cascade 37.5000 6 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0043687 post-translational protein modification 37.5000 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0051253 negative regulation of RNA metabolic process 37.5000 6 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0070647 protein modification by small protein conjugation or removal 37.5000 6 no
GO:1901873 regulation of post-translational protein modification 37.5000 7 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 37.5000 8 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051347 positive regulation of transferase activity 37.5000 5 no
GO:0007043 cell-cell junction assembly 37.5000 6 yes
GO:0010975 regulation of neuron projection development 37.5000 7 yes
GO:0034329 cell junction assembly 37.5000 5 yes
GO:0034330 cell junction organization 37.5000 4 yes
GO:0034332 adherens junction organization 37.5000 6 yes
GO:0045216 cell-cell junction organization 37.5000 5 yes
GO:0045595 regulation of cell differentiation 37.5000 4 yes
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0051130 positive regulation of cellular component organization 37.5000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 yes
GO:0008104 protein localization 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009968 negative regulation of signal transduction 37.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010648 negative regulation of cell communication 37.5000 5 no
GO:0023057 negative regulation of signaling 37.5000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0031400 negative regulation of protein modification process 37.5000 7 no
GO:0032446 protein modification by small protein conjugation 37.5000 7 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042692 muscle cell differentiation 25.0000 4 no
GO:0043410 positive regulation of MAPK cascade 25.0000 7 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0045786 negative regulation of cell cycle 25.0000 5 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 8 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045930 negative regulation of mitotic cell cycle 25.0000 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0048732 gland development 25.0000 4 no
GO:0050808 synapse organization 25.0000 5 no
GO:0050982 detection of mechanical stimulus 25.0000 4 no
GO:0051052 regulation of DNA metabolic process 25.0000 5 no
GO:0051054 positive regulation of DNA metabolic process 25.0000 6 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0060828 regulation of canonical Wnt signaling pathway 25.0000 6 no
GO:0090090 negative regulation of canonical Wnt signaling pathway 25.0000 7 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0097091 synaptic vesicle clustering 25.0000 5 no
GO:0097479 synaptic vesicle localization 25.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 no
GO:0099536 synaptic signaling 25.0000 4 no
GO:0099537 trans-synaptic signaling 25.0000 5 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:2000177 regulation of neural precursor cell proliferation 25.0000 5 no
GO:0007420 brain development 25.0000 4 no
GO:0043113 receptor clustering 25.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006996 organelle organization 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0061097 regulation of protein tyrosine kinase activity 25.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0006469 negative regulation of protein kinase activity 25.0000 7 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009895 negative regulation of catabolic process 25.0000 5 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 25.0000 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 25.0000 5 yes
GO:0010720 positive regulation of cell development 25.0000 6 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 25.0000 5 yes
GO:0030030 cell projection organization 25.0000 4 yes
GO:0031175 neuron projection development 25.0000 6 yes
GO:0031346 positive regulation of cell projection organization 25.0000 6 yes
GO:0044331 cell-cell adhesion mediated by cadherin 25.0000 4 yes
GO:0045597 positive regulation of cell differentiation 25.0000 5 yes
GO:0050767 regulation of neurogenesis 25.0000 6 yes
GO:0050769 positive regulation of neurogenesis 25.0000 6 yes
GO:0050770 regulation of axonogenesis 25.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0051962 positive regulation of nervous system development 25.0000 5 yes
GO:0060284 regulation of cell development 25.0000 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 25.0000 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 yes
GO:1990138 neuron projection extension 25.0000 4 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0002065 columnar/cuboidal epithelial cell differentiation 25.0000 5 no
GO:0006508 proteolysis 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0007268 chemical synaptic transmission 25.0000 7 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010001 glial cell differentiation 25.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010564 regulation of cell cycle process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0030099 myeloid cell differentiation 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0030178 negative regulation of Wnt signaling pathway 25.0000 6 no
GO:0030855 epithelial cell differentiation 25.0000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0033233 regulation of protein sumoylation 25.0000 9 no
GO:0035994 response to muscle stretch 25.0000 4 no
GO:0035995 detection of muscle stretch 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRM_HUMAN [view interactions] Low throughput no yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
CK5P3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes