Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC6A9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SC6A9_HUMAN
GO:0000166 nucleotide binding 45.4545 4 no
GO:0003924 GTPase activity 45.4545 7 no
GO:0005525 GTP binding 45.4545 5 no
GO:0016462 pyrophosphatase activity 45.4545 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 45.4545 4 no
GO:0017076 purine nucleotide binding 45.4545 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 45.4545 6 no
GO:0019001 guanyl nucleotide binding 45.4545 6 no
GO:0032555 purine ribonucleotide binding 45.4545 4 no
GO:0032561 guanyl ribonucleotide binding 45.4545 5 no
GO:0035639 purine ribonucleoside triphosphate binding 45.4545 4 no
GO:0043168 anion binding 45.4545 4 no
GO:0019003 GDP binding 36.3636 5 no
GO:0019900 kinase binding 27.2727 4 no
GO:0003723 RNA binding 27.2727 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 18.1818 4 yes
GO:0015081 sodium ion transmembrane transporter activity 18.1818 6 yes
GO:0015175 neutral L-amino acid transmembrane transporter activity 18.1818 4 yes
GO:0015179 L-amino acid transmembrane transporter activity 18.1818 4 yes
GO:0015291 secondary active transmembrane transporter activity 18.1818 4 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 18.1818 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 18.1818 4 yes
GO:0046873 metal ion transmembrane transporter activity 18.1818 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 18.1818 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC6A9_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0009966 regulation of signal transduction 54.5455 4 yes
GO:0010646 regulation of cell communication 54.5455 4 yes
GO:0048523 negative regulation of cellular process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 45.4545 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 yes
GO:0031323 regulation of cellular metabolic process 45.4545 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.4545 5 yes
GO:0050804 modulation of chemical synaptic transmission 45.4545 5 yes
GO:0051246 regulation of protein metabolic process 45.4545 5 yes
GO:0051247 positive regulation of protein metabolic process 45.4545 6 yes
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 yes
GO:0080090 regulation of primary metabolic process 45.4545 4 yes
GO:0099177 regulation of trans-synaptic signaling 45.4545 4 yes
GO:0009967 positive regulation of signal transduction 45.4545 5 no
GO:0010647 positive regulation of cell communication 45.4545 5 no
GO:0023056 positive regulation of signaling 45.4545 4 no
GO:0048584 positive regulation of response to stimulus 45.4545 4 no
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:0007264 small GTPase-mediated signal transduction 45.4545 5 no
GO:0141124 intracellular signaling cassette 45.4545 4 no
GO:0009889 regulation of biosynthetic process 36.3636 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 yes
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 yes
GO:0071702 organic substance transport 36.3636 4 yes
GO:0071705 nitrogen compound transport 36.3636 4 yes
GO:0098657 import into cell 36.3636 4 yes
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0006996 organelle organization 36.3636 4 no
GO:0010562 positive regulation of phosphorus metabolic process 36.3636 6 no
GO:0019220 regulation of phosphate metabolic process 36.3636 6 no
GO:0031399 regulation of protein modification process 36.3636 6 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0042327 positive regulation of phosphorylation 36.3636 8 no
GO:0045937 positive regulation of phosphate metabolic process 36.3636 7 no
GO:0051094 positive regulation of developmental process 36.3636 4 no
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 no
GO:0006915 apoptotic process 36.3636 4 no
GO:0042127 regulation of cell population proliferation 36.3636 4 no
GO:0042981 regulation of apoptotic process 36.3636 5 no
GO:0043067 regulation of programmed cell death 36.3636 4 no
GO:0051240 positive regulation of multicellular organismal process 36.3636 4 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 27.2727 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 27.2727 6 yes
GO:0051049 regulation of transport 27.2727 4 yes
GO:0008104 protein localization 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0033674 positive regulation of kinase activity 27.2727 6 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0043549 regulation of kinase activity 27.2727 5 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0045859 regulation of protein kinase activity 27.2727 6 no
GO:0045860 positive regulation of protein kinase activity 27.2727 7 no
GO:0048168 regulation of neuronal synaptic plasticity 27.2727 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 27.2727 5 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0051338 regulation of transferase activity 27.2727 4 no
GO:0051347 positive regulation of transferase activity 27.2727 5 no
GO:0002009 morphogenesis of an epithelium 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 6 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0030335 positive regulation of cell migration 27.2727 6 no
GO:0040017 positive regulation of locomotion 27.2727 4 no
GO:0043066 negative regulation of apoptotic process 27.2727 6 no
GO:0043069 negative regulation of programmed cell death 27.2727 5 no
GO:0043523 regulation of neuron apoptotic process 27.2727 6 no
GO:0043524 negative regulation of neuron apoptotic process 27.2727 7 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0051402 neuron apoptotic process 27.2727 5 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:2000026 regulation of multicellular organismal development 27.2727 4 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:2000147 positive regulation of cell motility 27.2727 5 no
GO:0000165 MAPK cascade 27.2727 5 no
GO:0007265 Ras protein signal transduction 27.2727 6 no
GO:0008284 positive regulation of cell population proliferation 27.2727 5 no
GO:0003018 vascular process in circulatory system 18.1818 4 yes
GO:0006811 monoatomic ion transport 18.1818 4 yes
GO:0006812 monoatomic cation transport 18.1818 5 yes
GO:0006865 amino acid transport 18.1818 5 yes
GO:0007268 chemical synaptic transmission 18.1818 7 yes
GO:0015695 organic cation transport 18.1818 5 yes
GO:0015711 organic anion transport 18.1818 5 yes
GO:0015804 neutral amino acid transport 18.1818 6 yes
GO:0015807 L-amino acid transport 18.1818 5 yes
GO:0015849 organic acid transport 18.1818 5 yes
GO:0022898 regulation of transmembrane transporter activity 18.1818 4 yes
GO:0030001 metal ion transport 18.1818 6 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 18.1818 5 yes
GO:0034762 regulation of transmembrane transport 18.1818 4 yes
GO:0046942 carboxylic acid transport 18.1818 6 yes
GO:0051051 negative regulation of transport 18.1818 4 yes
GO:0089718 amino acid import across plasma membrane 18.1818 4 yes
GO:0098916 anterograde trans-synaptic signaling 18.1818 6 yes
GO:0099536 synaptic signaling 18.1818 4 yes
GO:0099537 trans-synaptic signaling 18.1818 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 18.1818 4 yes
GO:1902475 L-alpha-amino acid transmembrane transport 18.1818 4 yes
GO:1905039 carboxylic acid transmembrane transport 18.1818 4 yes
GO:2000310 regulation of NMDA receptor activity 18.1818 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA1_HUMAN [view interactions] Low throughput no yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
H15_HUMAN [view interactions] High throughput no no
IGHG1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
THOC2_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
4F2_HUMAN [view entry] [view interactions] High throughput yes no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
LAT1_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DTX2_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes