SC6A9_HUMAN
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SC6A9_HUMAN |
---|---|---|---|---|
GO:0003924 | GTPase activity | 50.0000 | 7 | no |
GO:0005525 | GTP binding | 50.0000 | 5 | no |
GO:0016462 | pyrophosphatase activity | 50.0000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 50.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 50.0000 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 50.0000 | 5 | no |
GO:0019003 | GDP binding | 50.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0032561 | guanyl ribonucleotide binding | 50.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0019900 | kinase binding | 40.0000 | 4 | no |
GO:0019901 | protein kinase binding | 30.0000 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SC6A9_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 50.0000 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 50.0000 | 6 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0007264 | small GTPase mediated signal transduction | 50.0000 | 4 | no |
GO:0007265 | Ras protein signal transduction | 50.0000 | 5 | no |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 50.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 50.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
GO:0043269 | regulation of ion transport | 40.0000 | 5 | yes |
GO:0060341 | regulation of cellular localization | 40.0000 | 4 | yes |
GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 40.0000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 40.0000 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 40.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 40.0000 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 40.0000 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 40.0000 | 6 | no |
GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 40.0000 | 7 | no |
GO:0042325 | regulation of phosphorylation | 40.0000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 40.0000 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 40.0000 | 7 | no |
GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 40.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.0000 | 6 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 30.0000 | 6 | yes |
GO:0051050 | positive regulation of transport | 30.0000 | 4 | yes |
GO:0071702 | organic substance transport | 30.0000 | 4 | yes |
GO:0071705 | nitrogen compound transport | 30.0000 | 4 | yes |
GO:0002009 | morphogenesis of an epithelium | 30.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
GO:0008104 | protein localization | 30.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 30.0000 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 30.0000 | 5 | no |
GO:0030334 | regulation of cell migration | 30.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 30.0000 | 6 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 30.0000 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 30.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 30.0000 | 5 | no |
GO:0040017 | positive regulation of locomotion | 30.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 30.0000 | 6 | no |
GO:0051726 | regulation of cell cycle | 30.0000 | 4 | no |
GO:2000145 | regulation of cell motility | 30.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 30.0000 | 5 | no |
GO:0000165 | MAPK cascade | 30.0000 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 30.0000 | 5 | no |
GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
GO:0033674 | positive regulation of kinase activity | 30.0000 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 30.0000 | 4 | no |
GO:0043549 | regulation of kinase activity | 30.0000 | 5 | no |
GO:0044057 | regulation of system process | 30.0000 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 30.0000 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 30.0000 | 7 | no |
GO:0048168 | regulation of neuronal synaptic plasticity | 30.0000 | 4 | no |
GO:0048169 | regulation of long-term neuronal synaptic plasticity | 30.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 30.0000 | 5 | no |
GO:0010468 | regulation of gene expression | 30.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 30.0000 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 30.0000 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 30.0000 | 6 | no |
GO:0043523 | regulation of neuron apoptotic process | 30.0000 | 6 | no |
GO:0043524 | negative regulation of neuron apoptotic process | 30.0000 | 7 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
GO:0060548 | negative regulation of cell death | 30.0000 | 5 | no |
GO:1901214 | regulation of neuron death | 30.0000 | 5 | no |
GO:1901215 | negative regulation of neuron death | 30.0000 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 30.0000 | 6 | no |
GO:0003018 | vascular process in circulatory system | 20.0000 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 20.0000 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 20.0000 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 20.0000 | 5 | yes |
GO:0034762 | regulation of transmembrane transport | 20.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 20.0000 | 5 | yes |
GO:0043270 | positive regulation of ion transport | 20.0000 | 5 | yes |
GO:0051051 | negative regulation of transport | 20.0000 | 4 | yes |
GO:0099601 | regulation of neurotransmitter receptor activity | 20.0000 | 4 | yes |
GO:1904062 | regulation of cation transmembrane transport | 20.0000 | 6 | yes |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 20.0000 | 6 | yes |
GO:2000310 | regulation of NMDA receptor activity | 20.0000 | 5 | yes |
GO:2001257 | regulation of cation channel activity | 20.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITA1_HUMAN | [view interactions] | Low throughput | no | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
THOC2_HUMAN | [view interactions] | High throughput | no | yes |
UPK1A_HUMAN | [view interactions] | High throughput | no | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAT1_HUMAN | [view interactions] | High throughput | no | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H15_HUMAN | [view interactions] | High throughput | no | no |
IGHG1_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
TM216_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |