SMS_HUMAN
Evidence for PS localization
Functions
May enhance low-glucose-induced glucagon release by pancreatic alpha cells . This effect may be mediated by binding to GPR107 and PKA activation . May regulate cardiac contractile function . May compromise cardiomyocyte viability . In the central nervous system, may impair memory retention and may affect hippocampal excitability . May also have anxiolytic and anorexigenic effects . May play a role in arterial pressure regulation . May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 58 | Phe | Leu | Intellectualdevelopmentaldisorder,X-linked,syndromic,Snyder-Robinsontype(MRXSSR) | - |
| 56 | Gly | Ser | Intellectualdevelopmentaldisorder,X-linked,syndromic,Snyder-Robinsontype(MRXSSR) | - |
| 67 | Gly | Glu | Intellectualdevelopmentaldisorder,X-linked,syndromic,Snyder-Robinsontype(MRXSSR) | - |
| 132 | Val | Gly | Intellectualdevelopmentaldisorder,X-linked,syndromic,Snyder-Robinsontype(MRXSSR) | - |
| 328 | Tyr | Cys | Intellectualdevelopmentaldisorder,X-linked,syndromic,Snyder-Robinsontype(MRXSSR) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SMS_HUMAN |
|---|---|---|---|---|
| GO:0048018 | receptor ligand activity | 40.0000 | 4 | yes |
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0003924 | GTPase activity | 40.0000 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 40.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 40.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 40.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SMS_HUMAN |
|---|---|---|---|---|
| GO:0014070 | response to organic cyclic compound | 80.0000 | 4 | yes |
| GO:0033993 | response to lipid | 80.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 80.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 80.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 80.0000 | 4 | no |
| GO:0071396 | cellular response to lipid | 60.0000 | 5 | no |
| GO:0071407 | cellular response to organic cyclic compound | 60.0000 | 5 | no |
| GO:0097305 | response to alcohol | 60.0000 | 4 | no |
| GO:0097306 | cellular response to alcohol | 60.0000 | 5 | no |
| GO:1901654 | response to ketone | 60.0000 | 4 | no |
| GO:1901655 | cellular response to ketone | 60.0000 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 60.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 60.0000 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 60.0000 | 4 | no |
| GO:0071379 | cellular response to prostaglandin stimulus | 40.0000 | 5 | no |
| GO:0071380 | cellular response to prostaglandin E stimulus | 40.0000 | 6 | no |
| GO:0071867 | response to monoamine | 40.0000 | 5 | no |
| GO:0071868 | cellular response to monoamine stimulus | 40.0000 | 5 | no |
| GO:0071869 | response to catecholamine | 40.0000 | 4 | no |
| GO:0071870 | cellular response to catecholamine stimulus | 40.0000 | 5 | no |
| GO:0008285 | negative regulation of cell population proliferation | 40.0000 | 5 | yes |
| GO:0030334 | regulation of cell migration | 40.0000 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 40.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 40.0000 | 5 | no |
| GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway | 40.0000 | 4 | no |
| GO:0032870 | cellular response to hormone stimulus | 40.0000 | 4 | no |
| GO:0034694 | response to prostaglandin | 40.0000 | 4 | no |
| GO:0034695 | response to prostaglandin E | 40.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDIA2_HUMAN | [view interactions] | Low throughput | no | no |
| CREB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SSR3_HUMAN | [view interactions] | Low throughput | no | yes |
| SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SSR4_HUMAN | [view interactions] | Low throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |