Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDLI4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDLI4_HUMAN
GO:0017076 purine nucleotide binding 55.5556 4 no
GO:0032555 purine ribonucleotide binding 55.5556 4 no
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 no
GO:0003779 actin binding 44.4444 4 yes
GO:0003924 GTPase activity 44.4444 7 no
GO:0005525 GTP binding 44.4444 5 no
GO:0016462 pyrophosphatase activity 44.4444 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 44.4444 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 44.4444 6 no
GO:0019001 guanyl nucleotide binding 44.4444 5 no
GO:0032561 guanyl ribonucleotide binding 44.4444 5 no
GO:0042803 protein homodimerization activity 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 4 yes
GO:0019003 GDP binding 33.3333 4 no
GO:0019902 phosphatase binding 22.2222 4 yes
GO:0019903 protein phosphatase binding 22.2222 5 yes
GO:0042805 actinin binding 22.2222 4 yes
GO:0051371 muscle alpha-actinin binding 22.2222 6 yes
GO:0051393 alpha-actinin binding 22.2222 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDLI4_HUMAN
GO:0006996 organelle organization 66.6667 4 yes
GO:0007010 cytoskeleton organization 66.6667 5 yes
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0007264 small GTPase mediated signal transduction 55.5556 4 no
GO:0007268 chemical synaptic transmission 44.4444 6 yes
GO:0098916 anterograde trans-synaptic signaling 44.4444 5 yes
GO:0099537 trans-synaptic signaling 44.4444 4 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 5 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0051171 regulation of nitrogen compound metabolic process 44.4444 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0007265 Ras protein signal transduction 44.4444 5 no
GO:0008284 positive regulation of cell population proliferation 44.4444 5 no
GO:0042127 regulation of cell population proliferation 44.4444 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 7 no
GO:0007015 actin filament organization 33.3333 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0000165 MAPK cascade 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0007507 heart development 22.2222 4 yes
GO:0031532 actin cytoskeleton reorganization 22.2222 4 yes
GO:0098976 excitatory chemical synaptic transmission 22.2222 7 yes
GO:0006886 intracellular protein transport 22.2222 4 no
GO:0006897 endocytosis 22.2222 5 no
GO:0008104 protein localization 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0015031 protein transport 22.2222 4 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0032872 regulation of stress-activated MAPK cascade 22.2222 6 no
GO:0032874 positive regulation of stress-activated MAPK cascade 22.2222 7 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0046328 regulation of JNK cascade 22.2222 7 no
GO:0046330 positive regulation of JNK cascade 22.2222 8 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 22.2222 5 no
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 22.2222 6 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:1901215 negative regulation of neuron death 22.2222 6 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:0001894 tissue homeostasis 22.2222 5 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030031 cell projection assembly 22.2222 5 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0048872 homeostasis of number of cells 22.2222 4 no
GO:0048873 homeostasis of number of cells within a tissue 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0060249 anatomical structure homeostasis 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRIP6_HUMAN [view interactions] Low throughput no yes
PTN13_HUMAN [view interactions] Low throughput no yes
PDLI4_HUMAN [view entry] [view interactions] Low throughput yes yes
ZN408_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
KI3L2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
F222B_HUMAN [view interactions] High throughput no yes
TFE2_HUMAN [view interactions] High throughput no no
NFE2_HUMAN [view interactions] High throughput no no
ZBTB9_HUMAN [view interactions] High throughput no no
SSBP3_HUMAN [view interactions] High throughput no no
RBPMS_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
GCST_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
EWS_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
PML_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] Computational no no
RAC3_HUMAN [view entry] [view interactions] Computational yes no
MYO1A_HUMAN [view interactions] Computational no no
MYO6_HUMAN [view entry] [view interactions] Computational yes no