Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDLI4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDLI4_HUMAN
GO:0043168 anion binding 58.3333 4 no
GO:0000166 nucleotide binding 50.0000 4 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017076 purine nucleotide binding 50.0000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0003723 RNA binding 33.3333 4 no
GO:0003779 actin binding 25.0000 4 yes
GO:0042803 protein homodimerization activity 25.0000 4 yes
GO:0043169 cation binding 25.0000 4 yes
GO:0046872 metal ion binding 25.0000 5 yes
GO:0005524 ATP binding 25.0000 5 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0055131 C3HC4-type RING finger domain binding 25.0000 4 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0019001 guanyl nucleotide binding 25.0000 6 no
GO:0019003 GDP binding 25.0000 5 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0019902 phosphatase binding 16.6667 4 yes
GO:0019903 protein phosphatase binding 16.6667 5 yes
GO:0042805 actinin binding 16.6667 4 yes
GO:0051371 muscle alpha-actinin binding 16.6667 6 yes
GO:0051393 alpha-actinin binding 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDLI4_HUMAN
GO:0006996 organelle organization 58.3333 4 yes
GO:0009889 regulation of biosynthetic process 58.3333 4 no
GO:0010468 regulation of gene expression 58.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 58.3333 5 no
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 58.3333 5 no
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0009890 negative regulation of biosynthetic process 50.0000 5 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 50.0000 6 no
GO:0042981 regulation of apoptotic process 50.0000 5 no
GO:0043067 regulation of programmed cell death 50.0000 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 no
GO:0006355 regulation of DNA-templated transcription 41.6667 7 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0009967 positive regulation of signal transduction 41.6667 5 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0010647 positive regulation of cell communication 41.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.6667 5 no
GO:0023056 positive regulation of signaling 41.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 41.6667 4 no
GO:0051252 regulation of RNA metabolic process 41.6667 5 no
GO:2001141 regulation of RNA biosynthetic process 41.6667 6 no
GO:0007010 cytoskeleton organization 41.6667 5 yes
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0033043 regulation of organelle organization 41.6667 5 no
GO:0043066 negative regulation of apoptotic process 41.6667 6 no
GO:0043069 negative regulation of programmed cell death 41.6667 5 no
GO:0051129 negative regulation of cellular component organization 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:1902115 regulation of organelle assembly 33.3333 5 no
GO:0007264 small GTPase-mediated signal transduction 33.3333 5 no
GO:0007265 Ras protein signal transduction 33.3333 6 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0001817 regulation of cytokine production 33.3333 4 no
GO:0009057 macromolecule catabolic process 33.3333 4 no
GO:0010629 negative regulation of gene expression 33.3333 7 no
GO:0016070 RNA metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0090304 nucleic acid metabolic process 33.3333 4 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1901874 negative regulation of post-translational protein modification 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:0001819 positive regulation of cytokine production 25.0000 5 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0006163 purine nucleotide metabolic process 25.0000 5 no
GO:0006753 nucleoside phosphate metabolic process 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0009117 nucleotide metabolic process 25.0000 5 no
GO:0009141 nucleoside triphosphate metabolic process 25.0000 5 no
GO:0009144 purine nucleoside triphosphate metabolic process 25.0000 6 no
GO:0009150 purine ribonucleotide metabolic process 25.0000 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 25.0000 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 25.0000 7 no
GO:0009259 ribonucleotide metabolic process 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0016071 mRNA metabolic process 25.0000 6 no
GO:0019693 ribose phosphate metabolic process 25.0000 4 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 no
GO:0033993 response to lipid 25.0000 4 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0046034 ATP metabolic process 25.0000 7 no
GO:0048545 response to steroid hormone 25.0000 4 no
GO:0050778 positive regulation of immune response 25.0000 5 no
GO:0051084 de novo post-translational protein folding 25.0000 4 no
GO:0051085 chaperone cofactor-dependent protein refolding 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071383 cellular response to steroid hormone stimulus 25.0000 5 no
GO:0071396 cellular response to lipid 25.0000 5 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0072521 purine-containing compound metabolic process 25.0000 4 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0000165 MAPK cascade 25.0000 5 no
GO:0007268 chemical synaptic transmission 25.0000 7 yes
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 yes
GO:0099536 synaptic signaling 25.0000 4 yes
GO:0099537 trans-synaptic signaling 25.0000 5 yes
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031397 negative regulation of protein ubiquitination 25.0000 10 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0062197 cellular response to chemical stress 25.0000 4 no
GO:0007507 heart development 16.6667 4 yes
GO:0098976 excitatory chemical synaptic transmission 16.6667 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRIP6_HUMAN [view interactions] Low throughput no yes
PTN13_HUMAN [view interactions] Low throughput no yes
PDLI4_HUMAN [view entry] [view interactions] Low throughput yes yes
ZN408_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
KI3L2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
F222B_HUMAN [view interactions] High throughput no yes
NFE2_HUMAN [view interactions] High throughput no no
TFE2_HUMAN [view interactions] High throughput no no
ZBTB9_HUMAN [view interactions] High throughput no no
SSBP3_HUMAN [view interactions] High throughput no no
RBPMS_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
GCST_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
PML_HUMAN [view interactions] High throughput no yes