Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AT8A2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AT8A2_HUMAN
GO:0000166 nucleotide binding 75.0000 4 yes
GO:0017076 purine nucleotide binding 75.0000 5 yes
GO:0030554 adenyl nucleotide binding 75.0000 6 yes
GO:0032555 purine ribonucleotide binding 75.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 75.0000 5 yes
GO:0043168 anion binding 75.0000 4 yes
GO:0043169 cation binding 75.0000 4 yes
GO:0046872 metal ion binding 75.0000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 75.0000 4 no
GO:0000287 magnesium ion binding 50.0000 6 yes
GO:0005524 ATP binding 50.0000 5 yes
GO:0015247 aminophospholipid flippase activity 50.0000 4 yes
GO:0016462 pyrophosphatase activity 50.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 yes
GO:0016887 ATP hydrolysis activity 50.0000 7 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 yes
GO:0090556 phosphatidylserine floppase activity 50.0000 4 yes
GO:0140333 glycerophospholipid flippase activity 50.0000 4 yes
GO:0140346 phosphatidylserine flippase activity 50.0000 5 yes
GO:0005216 monoatomic ion channel activity 50.0000 4 no
GO:0005244 voltage-gated monoatomic ion channel activity 50.0000 5 no
GO:0005261 monoatomic cation channel activity 50.0000 5 no
GO:0015267 channel activity 50.0000 4 no
GO:0022832 voltage-gated channel activity 50.0000 6 no
GO:0022836 gated channel activity 50.0000 5 no
GO:0022843 voltage-gated monoatomic cation channel activity 50.0000 6 no
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in AT8A2_HUMAN
GO:0051049 regulation of transport 75.0000 4 yes
GO:0006811 monoatomic ion transport 75.0000 4 no
GO:0006869 lipid transport 50.0000 5 yes
GO:0015748 organophosphate ester transport 50.0000 5 yes
GO:0015914 phospholipid transport 50.0000 6 yes
GO:0015917 aminophospholipid transport 50.0000 5 yes
GO:0032368 regulation of lipid transport 50.0000 5 yes
GO:0032370 positive regulation of lipid transport 50.0000 5 yes
GO:0034204 lipid translocation 50.0000 4 yes
GO:0045332 phospholipid translocation 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0048666 neuron development 50.0000 4 yes
GO:0051050 positive regulation of transport 50.0000 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0061024 membrane organization 50.0000 4 yes
GO:0061091 regulation of phospholipid translocation 50.0000 4 yes
GO:0061092 positive regulation of phospholipid translocation 50.0000 5 yes
GO:0071702 organic substance transport 50.0000 4 yes
GO:0071705 nitrogen compound transport 50.0000 4 yes
GO:0140331 aminophospholipid translocation 50.0000 6 yes
GO:1905952 regulation of lipid localization 50.0000 4 yes
GO:1905954 positive regulation of lipid localization 50.0000 4 yes
GO:2001138 regulation of phospholipid transport 50.0000 6 yes
GO:2001140 positive regulation of phospholipid transport 50.0000 6 yes
GO:0001508 action potential 50.0000 4 no
GO:0006812 monoatomic cation transport 50.0000 5 no
GO:0030001 metal ion transport 50.0000 6 no
GO:0098655 monoatomic cation transmembrane transport 50.0000 4 no
GO:0098662 inorganic cation transmembrane transport 50.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CC50A_HUMAN [view interactions] Low throughput no yes
UIMC1_HUMAN [view interactions] Low throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
ARCH_HUMAN [view interactions] High throughput no no
SMRCD_HUMAN [view interactions] High throughput no yes
CNPY3_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes