Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA7_HUMAN
GO:0005216 ion channel activity 47.3684 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 47.3684 6 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 47.3684 7 yes
GO:0005261 cation channel activity 47.3684 5 yes
GO:0008324 cation transmembrane transporter activity 47.3684 4 yes
GO:0015267 channel activity 47.3684 4 yes
GO:0015276 ligand-gated ion channel activity 47.3684 5 yes
GO:0022824 transmitter-gated ion channel activity 47.3684 5 yes
GO:0022834 ligand-gated channel activity 47.3684 6 yes
GO:0022835 transmitter-gated channel activity 47.3684 4 yes
GO:0022836 gated channel activity 47.3684 5 yes
GO:0022848 acetylcholine-gated cation-selective channel activity 47.3684 7 yes
GO:0022890 inorganic cation transmembrane transporter activity 47.3684 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 47.3684 4 yes
GO:0099094 ligand-gated cation channel activity 47.3684 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 47.3684 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 47.3684 6 yes
GO:0015464 acetylcholine receptor activity 36.8421 4 yes
GO:0046872 metal ion binding 31.5789 4 no
GO:0001540 amyloid-beta binding 21.0526 4 yes
GO:0042803 protein homodimerization activity 21.0526 4 yes
GO:0001664 G protein-coupled receptor binding 21.0526 4 no
GO:0005262 calcium channel activity 15.7895 6 yes
GO:0015085 calcium ion transmembrane transporter activity 15.7895 6 yes
GO:0046873 metal ion transmembrane transporter activity 15.7895 5 yes
GO:0017081 chloride channel regulator activity 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA7_HUMAN
GO:0010646 regulation of cell communication 63.1579 4 yes
GO:0048522 positive regulation of cellular process 57.8947 4 yes
GO:0098916 anterograde trans-synaptic signaling 52.6316 5 yes
GO:0099177 regulation of trans-synaptic signaling 52.6316 4 yes
GO:0099537 trans-synaptic signaling 52.6316 4 yes
GO:0051049 regulation of transport 52.6316 4 no
GO:0006811 ion transport 52.6316 4 yes
GO:0007268 chemical synaptic transmission 52.6316 6 yes
GO:0050804 modulation of chemical synaptic transmission 52.6316 5 yes
GO:0007271 synaptic transmission, cholinergic 47.3684 7 yes
GO:0030030 cell projection organization 47.3684 4 yes
GO:0051128 regulation of cellular component organization 47.3684 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.1053 4 yes
GO:0080090 regulation of primary metabolic process 42.1053 4 yes
GO:0120036 plasma membrane bounded cell projection organization 42.1053 5 yes
GO:0009966 regulation of signal transduction 42.1053 4 yes
GO:0031323 regulation of cellular metabolic process 42.1053 4 yes
GO:0048523 negative regulation of cellular process 42.1053 4 yes
GO:0050890 cognition 42.1053 4 yes
GO:0051899 membrane depolarization 42.1053 4 yes
GO:1902531 regulation of intracellular signal transduction 36.8421 5 yes
GO:0001932 regulation of protein phosphorylation 36.8421 7 yes
GO:0009893 positive regulation of metabolic process 36.8421 4 yes
GO:0010468 regulation of gene expression 36.8421 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.8421 5 yes
GO:0019220 regulation of phosphate metabolic process 36.8421 6 yes
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 yes
GO:0031399 regulation of protein modification process 36.8421 6 yes
GO:0042127 regulation of cell population proliferation 36.8421 4 yes
GO:0042325 regulation of phosphorylation 36.8421 7 yes
GO:0043085 positive regulation of catalytic activity 36.8421 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 36.8421 5 yes
GO:0051174 regulation of phosphorus metabolic process 36.8421 5 yes
GO:0051246 regulation of protein metabolic process 36.8421 5 yes
GO:0051247 positive regulation of protein metabolic process 36.8421 6 yes
GO:0106027 neuron projection organization 31.5789 6 yes
GO:1901214 regulation of neuron death 31.5789 5 yes
GO:0060341 regulation of cellular localization 31.5789 4 no
GO:0051046 regulation of secretion 31.5789 5 no
GO:1903530 regulation of secretion by cell 31.5789 4 no
GO:0031344 regulation of cell projection organization 31.5789 5 no
GO:0043269 regulation of ion transport 31.5789 5 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.5789 6 no
GO:0001934 positive regulation of protein phosphorylation 31.5789 8 yes
GO:0007613 memory 31.5789 4 yes
GO:0009892 negative regulation of metabolic process 31.5789 4 yes
GO:0010243 response to organonitrogen compound 31.5789 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 31.5789 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 yes
GO:0010629 negative regulation of gene expression 31.5789 6 yes
GO:0010647 positive regulation of cell communication 31.5789 5 yes
GO:0010941 regulation of cell death 31.5789 4 yes
GO:0023056 positive regulation of signaling 31.5789 4 yes
GO:0031324 negative regulation of cellular metabolic process 31.5789 5 yes
GO:0031401 positive regulation of protein modification process 31.5789 7 yes
GO:0042327 positive regulation of phosphorylation 31.5789 8 yes
GO:0044057 regulation of system process 31.5789 4 yes
GO:0045937 positive regulation of phosphate metabolic process 31.5789 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 31.5789 5 yes
GO:0051240 positive regulation of multicellular organismal process 31.5789 4 yes
GO:0051338 regulation of transferase activity 31.5789 4 yes
GO:0055065 metal ion homeostasis 26.3158 7 yes
GO:0055080 cation homeostasis 26.3158 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 26.3158 7 yes
GO:0097061 dendritic spine organization 26.3158 5 yes
GO:0098771 inorganic ion homeostasis 26.3158 6 yes
GO:0099173 postsynapse organization 26.3158 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 26.3158 6 yes
GO:1900271 regulation of long-term synaptic potentiation 26.3158 4 yes
GO:1901652 response to peptide 26.3158 4 yes
GO:1902533 positive regulation of intracellular signal transduction 26.3158 6 yes
GO:1902903 regulation of supramolecular fiber organization 26.3158 5 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 26.3158 6 yes
GO:1904645 response to amyloid-beta 26.3158 5 yes
GO:0006796 phosphate-containing compound metabolic process 26.3158 4 no
GO:0010648 negative regulation of cell communication 26.3158 5 no
GO:0023057 negative regulation of signaling 26.3158 4 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0043933 protein-containing complex organization 26.3158 4 no
GO:0048585 negative regulation of response to stimulus 26.3158 4 no
GO:0050807 regulation of synapse organization 26.3158 5 no
GO:0050865 regulation of cell activation 26.3158 4 no
GO:0051129 negative regulation of cellular component organization 26.3158 5 no
GO:0051223 regulation of protein transport 26.3158 5 no
GO:0070201 regulation of establishment of protein localization 26.3158 6 no
GO:0006812 cation transport 26.3158 5 yes
GO:0006816 calcium ion transport 26.3158 7 yes
GO:0006873 cellular ion homeostasis 26.3158 4 yes
GO:0006875 cellular metal ion homeostasis 26.3158 6 yes
GO:0009967 positive regulation of signal transduction 26.3158 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 yes
GO:0030001 metal ion transport 26.3158 6 yes
GO:0030003 cellular cation homeostasis 26.3158 5 yes
GO:0032990 cell part morphogenesis 26.3158 4 yes
GO:0034248 regulation of cellular amide metabolic process 26.3158 5 yes
GO:0036293 response to decreased oxygen levels 26.3158 4 yes
GO:0043408 regulation of MAPK cascade 26.3158 6 yes
GO:0048584 positive regulation of response to stimulus 26.3158 4 yes
GO:0048812 neuron projection morphogenesis 26.3158 7 yes
GO:0048858 cell projection morphogenesis 26.3158 5 yes
GO:0048878 chemical homeostasis 26.3158 4 yes
GO:0050801 ion homeostasis 26.3158 5 yes
GO:0051094 positive regulation of developmental process 26.3158 4 yes
GO:0051241 negative regulation of multicellular organismal process 26.3158 4 yes
GO:0051248 negative regulation of protein metabolic process 26.3158 6 yes
GO:0051347 positive regulation of transferase activity 26.3158 5 yes
GO:0055074 calcium ion homeostasis 21.0526 8 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 21.0526 8 yes
GO:0072503 cellular divalent inorganic cation homeostasis 21.0526 6 yes
GO:0072507 divalent inorganic cation homeostasis 21.0526 7 yes
GO:0080164 regulation of nitric oxide metabolic process 21.0526 5 yes
GO:0095500 acetylcholine receptor signaling pathway 21.0526 4 yes
GO:1902003 regulation of amyloid-beta formation 21.0526 6 yes
GO:1902430 negative regulation of amyloid-beta formation 21.0526 7 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 21.0526 7 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 21.0526 7 yes
GO:1905144 response to acetylcholine 21.0526 4 yes
GO:1905906 regulation of amyloid fibril formation 21.0526 6 yes
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0035095 behavioral response to nicotine 21.0526 4 no
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0010942 positive regulation of cell death 21.0526 5 no
GO:0022607 cellular component assembly 21.0526 4 no
GO:0030162 regulation of proteolysis 21.0526 6 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0031345 negative regulation of cell projection organization 21.0526 6 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0050776 regulation of immune response 21.0526 4 no
GO:0060548 negative regulation of cell death 21.0526 5 no
GO:0065003 protein-containing complex assembly 21.0526 5 no
GO:0099175 regulation of postsynapse organization 21.0526 6 no
GO:1901216 positive regulation of neuron death 21.0526 6 no
GO:1902950 regulation of dendritic spine maintenance 21.0526 7 no
GO:1902951 negative regulation of dendritic spine maintenance 21.0526 7 no
GO:0010975 regulation of neuron projection development 21.0526 7 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0051130 positive regulation of cellular component organization 21.0526 5 no
GO:0001817 regulation of cytokine production 21.0526 4 yes
GO:0006874 cellular calcium ion homeostasis 21.0526 7 yes
GO:0008284 positive regulation of cell population proliferation 21.0526 5 yes
GO:0031644 regulation of nervous system process 21.0526 5 yes
GO:0034249 negative regulation of cellular amide metabolic process 21.0526 6 yes
GO:0043410 positive regulation of MAPK cascade 21.0526 7 yes
GO:0098815 modulation of excitatory postsynaptic potential 15.7895 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 15.7895 5 yes
GO:1902004 positive regulation of amyloid-beta formation 15.7895 7 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 15.7895 5 yes
GO:2000026 regulation of multicellular organismal development 15.7895 4 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 15.7895 5 yes
GO:0001818 negative regulation of cytokine production 15.7895 5 yes
GO:0032680 regulation of tumor necrosis factor production 15.7895 6 yes
GO:0034250 positive regulation of cellular amide metabolic process 15.7895 6 yes
GO:0034330 cell junction organization 15.7895 4 yes
GO:0048813 dendrite morphogenesis 15.7895 8 yes
GO:0050806 positive regulation of synaptic transmission 15.7895 5 yes
GO:0050808 synapse organization 15.7895 5 yes
GO:0140058 neuron projection arborization 10.5263 8 yes
GO:0140059 dendrite arborization 10.5263 9 yes
GO:1901342 regulation of vasculature development 10.5263 5 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 10.5263 6 yes
GO:1904018 positive regulation of vasculature development 10.5263 5 yes
GO:1905918 regulation of CoA-transferase activity 10.5263 5 yes
GO:1905920 positive regulation of CoA-transferase activity 10.5263 6 yes
GO:0007614 short-term memory 10.5263 5 yes
GO:0032720 negative regulation of tumor necrosis factor production 10.5263 7 yes
GO:0045765 regulation of angiogenesis 10.5263 5 yes
GO:0045766 positive regulation of angiogenesis 10.5263 6 yes
GO:0050893 sensory processing 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
SLUR1_HUMAN [view interactions] Low throughput no no
SLUR2_HUMAN [view interactions] Low throughput no no
LYNX1_HUMAN [view entry] [view interactions] Low throughput yes no
LYPD1_HUMAN [view interactions] Low throughput no no
CRFM7_HUMAN [view interactions] Low throughput no no
GRIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
A0A1W2PN81_HUMAN [view entry] [view interactions] Low throughput yes no
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
ADCY6_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
LYPD6_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
DBF4A_HUMAN [view interactions] High throughput no no
RBBP4_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
S12A4_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
PMYT1_HUMAN [view interactions] High throughput no no
SRBP1_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
TAP2_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
ANKL2_HUMAN [view interactions] High throughput no yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
PCX3_HUMAN [view interactions] High throughput no no
GCYB1_HUMAN [view interactions] High throughput no yes
PPWD1_HUMAN [view interactions] High throughput no yes
PTER_HUMAN [view interactions] High throughput no yes
UBCP1_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
OXSM_HUMAN [view interactions] High throughput no yes
ACHB4_HUMAN [view entry] [view interactions] Computational yes no
ACHA2_HUMAN [view entry] [view interactions] Computational yes no
ACHA9_HUMAN [view entry] [view interactions] Computational yes no
ACHA4_HUMAN [view entry] [view interactions] Computational yes no
ACHA3_HUMAN [view entry] [view interactions] Computational yes no