ACHA7_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 55%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [ACHA7_HUMAN]
Isoform [P36544-2] alignment
Isoform [P36544-3] alignment
Isoform [A0A1B0GV86] alignment
Isoform [A0A1B0GUR5] alignment
Isoform [A0A1B0GV25] alignment
Isoform [A0A1B0GV43] alignment
Isoform [A0A1B0GV44] alignment
Isoform [A0A1B0GTT9] alignment
Isoform [A0A1B0GU56] alignment
Isoform [A0A1B0GTT0] alignment
Isoform [A0A1B0GU93] alignment
Isoform [A0A1B0GU04] alignment
Isoform [A0A1B0GU11] alignment
Isoform [A0A1B0GTE0] alignment
Isoform [A0A1B0GWH1] alignment
Isoform [A0A1B0GVN6] alignment
Isoform [A0A1B0GVP9] alignment
Isoform [A0A1B0GW52] alignment
Isoform [A0A1B0GW47] alignment
Isoform [A0A1B0GVH2] alignment
Isoform [A0A1B0GVI5] alignment
Isoform [A0A1W2PN81] alignment
LOADING 11%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA7_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 69.2308 | 4 | yes |
| GO:0046872 | metal ion binding | 46.1538 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 23.0769 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 23.0769 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 23.0769 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 23.0769 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 23.0769 | 4 | yes |
| GO:0015267 | channel activity | 23.0769 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 23.0769 | 5 | yes |
| GO:0015464 | acetylcholine receptor activity | 23.0769 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 23.0769 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 23.0769 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 23.0769 | 4 | yes |
| GO:0022836 | gated channel activity | 23.0769 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 23.0769 | 7 | yes |
| GO:0042166 | acetylcholine binding | 23.0769 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 23.0769 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 23.0769 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 23.0769 | 6 | yes |
| GO:0099106 | ion channel regulator activity | 23.0769 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 23.0769 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 23.0769 | 6 | yes |
| GO:0001664 | G protein-coupled receptor binding | 23.0769 | 4 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | no |
| GO:0005262 | calcium channel activity | 15.3846 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA7_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 76.9231 | 4 | yes |
| GO:0030030 | cell projection organization | 69.2308 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 69.2308 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 69.2308 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 69.2308 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 61.5385 | 4 | yes |
| GO:0010468 | regulation of gene expression | 61.5385 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 61.5385 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 61.5385 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 61.5385 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.5385 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 61.5385 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 53.8462 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 53.8462 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.8462 | 4 | yes |
| GO:0050890 | cognition | 53.8462 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 53.8462 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.8462 | 4 | yes |
| GO:0051049 | regulation of transport | 53.8462 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 46.1538 | 7 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 46.1538 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.1538 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 46.1538 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADCY6_HUMAN | [view interactions] | Low throughput | no | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CRFM7_HUMAN | [view interactions] | Low throughput | no | no |
| DBF4A_HUMAN | [view interactions] | High throughput | no | no |
| DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LYPD1_HUMAN | [view interactions] | Low throughput | no | no |
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| OXSM_HUMAN | [view interactions] | High throughput | no | yes |
| PCX3_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PMYT1_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPWD1_HUMAN | [view interactions] | High throughput | no | yes |