Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA7_HUMAN
GO:0043169 cation binding 69.2308 4 yes
GO:0046872 metal ion binding 46.1538 5 no
GO:0005216 monoatomic ion channel activity 23.0769 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 23.0769 6 yes
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 23.0769 7 yes
GO:0005261 monoatomic cation channel activity 23.0769 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 23.0769 4 yes
GO:0015267 channel activity 23.0769 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 23.0769 5 yes
GO:0015464 acetylcholine receptor activity 23.0769 4 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 23.0769 5 yes
GO:0022834 ligand-gated channel activity 23.0769 6 yes
GO:0022835 transmitter-gated channel activity 23.0769 4 yes
GO:0022836 gated channel activity 23.0769 5 yes
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 23.0769 7 yes
GO:0042166 acetylcholine binding 23.0769 5 yes
GO:0042803 protein homodimerization activity 23.0769 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 23.0769 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 23.0769 6 yes
GO:0099106 ion channel regulator activity 23.0769 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 23.0769 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 23.0769 6 yes
GO:0001664 G protein-coupled receptor binding 23.0769 4 no
GO:0043168 anion binding 23.0769 4 no
GO:0005262 calcium channel activity 15.3846 6 yes
GO:0015085 calcium ion transmembrane transporter activity 15.3846 6 yes
GO:0017081 chloride channel regulator activity 15.3846 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 15.3846 4 yes
GO:0046873 metal ion transmembrane transporter activity 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA7_HUMAN
GO:0010646 regulation of cell communication 76.9231 4 yes
GO:0030030 cell projection organization 69.2308 4 yes
GO:0048522 positive regulation of cellular process 69.2308 4 yes
GO:0050804 modulation of chemical synaptic transmission 69.2308 5 yes
GO:0099177 regulation of trans-synaptic signaling 69.2308 4 yes
GO:0009889 regulation of biosynthetic process 61.5385 4 yes
GO:0010468 regulation of gene expression 61.5385 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.5385 5 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 yes
GO:0031326 regulation of cellular biosynthetic process 61.5385 5 yes
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0060255 regulation of macromolecule metabolic process 61.5385 4 yes
GO:0120036 plasma membrane bounded cell projection organization 61.5385 5 yes
GO:0009966 regulation of signal transduction 53.8462 4 yes
GO:0042127 regulation of cell population proliferation 53.8462 4 yes
GO:0048523 negative regulation of cellular process 53.8462 4 yes
GO:0050890 cognition 53.8462 4 yes
GO:0051240 positive regulation of multicellular organismal process 53.8462 4 yes
GO:0080090 regulation of primary metabolic process 53.8462 4 yes
GO:0051049 regulation of transport 53.8462 4 no
GO:0001932 regulation of protein phosphorylation 46.1538 7 yes
GO:0009890 negative regulation of biosynthetic process 46.1538 5 yes
GO:0009892 negative regulation of metabolic process 46.1538 4 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 yes
GO:0010243 response to organonitrogen compound 46.1538 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 46.1538 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.1538 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 yes
GO:0010629 negative regulation of gene expression 46.1538 7 yes
GO:0019220 regulation of phosphate metabolic process 46.1538 6 yes
GO:0031324 negative regulation of cellular metabolic process 46.1538 5 yes
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 46.1538 6 yes
GO:0031399 regulation of protein modification process 46.1538 6 yes
GO:0042325 regulation of phosphorylation 46.1538 7 yes
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 yes
GO:0051246 regulation of protein metabolic process 46.1538 5 yes
GO:0051247 positive regulation of protein metabolic process 46.1538 6 yes
GO:0106027 neuron projection organization 46.1538 6 yes
GO:1902531 regulation of intracellular signal transduction 46.1538 5 yes
GO:0001934 positive regulation of protein phosphorylation 38.4615 8 yes
GO:0006873 intracellular monoatomic ion homeostasis 38.4615 4 yes
GO:0007268 chemical synaptic transmission 38.4615 7 yes
GO:0007271 synaptic transmission, cholinergic 38.4615 8 yes
GO:0007613 memory 38.4615 4 yes
GO:0009967 positive regulation of signal transduction 38.4615 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 38.4615 6 yes
GO:0010647 positive regulation of cell communication 38.4615 5 yes
GO:0023056 positive regulation of signaling 38.4615 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 38.4615 5 yes
GO:0031401 positive regulation of protein modification process 38.4615 7 yes
GO:0042327 positive regulation of phosphorylation 38.4615 8 yes
GO:0043085 positive regulation of catalytic activity 38.4615 4 yes
GO:0045937 positive regulation of phosphate metabolic process 38.4615 7 yes
GO:0048584 positive regulation of response to stimulus 38.4615 4 yes
GO:0048812 neuron projection morphogenesis 38.4615 5 yes
GO:0051248 negative regulation of protein metabolic process 38.4615 6 yes
GO:0051338 regulation of transferase activity 38.4615 4 yes
GO:0055080 monoatomic cation homeostasis 38.4615 4 yes
GO:0097061 dendritic spine organization 38.4615 5 yes
GO:0098916 anterograde trans-synaptic signaling 38.4615 6 yes
GO:0099173 postsynapse organization 38.4615 4 yes
GO:0099536 synaptic signaling 38.4615 4 yes
GO:0099537 trans-synaptic signaling 38.4615 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 38.4615 4 yes
GO:1900271 regulation of long-term synaptic potentiation 38.4615 4 yes
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 yes
GO:1902903 regulation of supramolecular fiber organization 38.4615 5 yes
GO:1904645 response to amyloid-beta 38.4615 4 yes
GO:0050807 regulation of synapse organization 38.4615 5 no
GO:0060341 regulation of cellular localization 38.4615 4 no
GO:0006796 phosphate-containing compound metabolic process 38.4615 4 no
GO:0001817 regulation of cytokine production 30.7692 4 yes
GO:0006811 monoatomic ion transport 30.7692 4 yes
GO:0006812 monoatomic cation transport 30.7692 5 yes
GO:0006816 calcium ion transport 30.7692 7 yes
GO:0006874 intracellular calcium ion homeostasis 30.7692 5 yes
GO:0008284 positive regulation of cell population proliferation 30.7692 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 yes
GO:0030001 metal ion transport 30.7692 6 yes
GO:0034248 regulation of amide metabolic process 30.7692 4 yes
GO:0034249 negative regulation of amide metabolic process 30.7692 5 yes
GO:0036293 response to decreased oxygen levels 30.7692 4 yes
GO:0043408 regulation of MAPK cascade 30.7692 6 yes
GO:0043410 positive regulation of MAPK cascade 30.7692 7 yes
GO:0044057 regulation of system process 30.7692 4 yes
GO:0051094 positive regulation of developmental process 30.7692 4 yes
GO:0051241 negative regulation of multicellular organismal process 30.7692 4 yes
GO:0051347 positive regulation of transferase activity 30.7692 5 yes
GO:0055074 calcium ion homeostasis 30.7692 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 30.7692 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 30.7692 8 yes
GO:1902003 regulation of amyloid-beta formation 30.7692 5 yes
GO:1902430 negative regulation of amyloid-beta formation 30.7692 6 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 30.7692 6 yes
GO:1902992 negative regulation of amyloid precursor protein catabolic process 30.7692 7 yes
GO:1905906 regulation of amyloid fibril formation 30.7692 6 yes
GO:0031175 neuron projection development 30.7692 6 no
GO:0010648 negative regulation of cell communication 30.7692 5 no
GO:0023057 negative regulation of signaling 30.7692 4 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0043933 protein-containing complex organization 30.7692 4 no
GO:0050865 regulation of cell activation 30.7692 4 no
GO:0051129 negative regulation of cellular component organization 30.7692 5 no
GO:0070201 regulation of establishment of protein localization 30.7692 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:0036211 protein modification process 30.7692 4 no
GO:0043412 macromolecule modification 30.7692 4 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0001818 negative regulation of cytokine production 23.0769 5 yes
GO:0031644 regulation of nervous system process 23.0769 5 yes
GO:0032680 regulation of tumor necrosis factor production 23.0769 6 yes
GO:0034330 cell junction organization 23.0769 4 yes
GO:0048813 dendrite morphogenesis 23.0769 6 yes
GO:0050806 positive regulation of synaptic transmission 23.0769 5 yes
GO:0050808 synapse organization 23.0769 5 yes
GO:0095500 acetylcholine receptor signaling pathway 23.0769 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 23.0769 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 23.0769 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 23.0769 5 yes
GO:1905144 response to acetylcholine 23.0769 4 yes
GO:1905918 regulation of CoA-transferase activity 23.0769 5 yes
GO:1905920 positive regulation of CoA-transferase activity 23.0769 6 yes
GO:2000026 regulation of multicellular organismal development 23.0769 4 yes
GO:0002694 regulation of leukocyte activation 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0008285 negative regulation of cell population proliferation 23.0769 5 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0022607 cellular component assembly 23.0769 4 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0031345 negative regulation of cell projection organization 23.0769 6 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043549 regulation of kinase activity 23.0769 5 no
GO:0043954 cellular component maintenance 23.0769 4 no
GO:0045859 regulation of protein kinase activity 23.0769 6 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 no
GO:0050776 regulation of immune response 23.0769 4 no
GO:0051249 regulation of lymphocyte activation 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:0097062 dendritic spine maintenance 23.0769 5 no
GO:0099175 regulation of postsynapse organization 23.0769 6 no
GO:1900272 negative regulation of long-term synaptic potentiation 23.0769 4 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.0769 6 no
GO:1902950 regulation of dendritic spine maintenance 23.0769 7 no
GO:1904646 cellular response to amyloid-beta 23.0769 5 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0007612 learning 23.0769 4 no
GO:0009416 response to light stimulus 23.0769 4 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0051046 regulation of secretion 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:1903530 regulation of secretion by cell 23.0769 4 no
GO:0006468 protein phosphorylation 23.0769 5 no
GO:0009894 regulation of catabolic process 23.0769 4 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0031347 regulation of defense response 23.0769 5 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0050727 regulation of inflammatory response 23.0769 5 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0141124 intracellular signaling cassette 23.0769 4 no
GO:0008104 protein localization 23.0769 4 no
GO:0015031 protein transport 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0007614 short-term memory 15.3846 5 yes
GO:0032720 negative regulation of tumor necrosis factor production 15.3846 7 yes
GO:0034250 positive regulation of amide metabolic process 15.3846 5 yes
GO:0045765 regulation of angiogenesis 15.3846 5 yes
GO:0045766 positive regulation of angiogenesis 15.3846 6 yes
GO:0050893 sensory processing 15.3846 5 yes
GO:0140058 neuron projection arborization 15.3846 6 yes
GO:0140059 dendrite arborization 15.3846 7 yes
GO:1901342 regulation of vasculature development 15.3846 5 yes
GO:1902004 positive regulation of amyloid-beta formation 15.3846 6 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 15.3846 7 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 15.3846 6 yes
GO:1904018 positive regulation of vasculature development 15.3846 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SQSTM_HUMAN [view interactions] Low throughput no yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHB2_HUMAN [view entry] [view interactions] Low throughput yes no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
SLUR1_HUMAN [view interactions] Low throughput no no
SLUR2_HUMAN [view interactions] Low throughput no no
LYNX1_HUMAN [view entry] [view interactions] Low throughput yes no
LYPD1_HUMAN [view interactions] Low throughput no no
CRFM7_HUMAN [view interactions] Low throughput no no
GRIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACHA7_HUMAN [view entry] [view interactions] Low throughput yes yes
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
ADCY6_HUMAN [view interactions] Low throughput no yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
PRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
PCX3_HUMAN [view interactions] High throughput no no
GCYB1_HUMAN [view interactions] High throughput no yes
PPWD1_HUMAN [view interactions] High throughput no yes
PTER_HUMAN [view interactions] High throughput no yes
UBCP1_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
OXSM_HUMAN [view interactions] High throughput no yes
LYPD6_HUMAN [view interactions] High throughput no no
RBBP4_HUMAN [view interactions] High throughput no yes
DBF4A_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
S12A4_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
PMYT1_HUMAN [view interactions] High throughput no no
SRBP1_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
TAP2_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
ANKL2_HUMAN [view interactions] High throughput no yes