Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PGM2L_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PGM2L_HUMAN
GO:0043169 cation binding 33.3333 4 yes
GO:0046872 metal ion binding 33.3333 5 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0042803 protein homodimerization activity 33.3333 4 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PGM2L_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0030030 cell projection organization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0031346 positive regulation of cell projection organization 50.0000 6 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0048812 neuron projection morphogenesis 50.0000 5 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 50.0000 4 no
GO:0032880 regulation of protein localization 50.0000 5 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0006006 glucose metabolic process 33.3333 5 yes
GO:0019318 hexose metabolic process 33.3333 4 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099173 postsynapse organization 33.3333 4 no
GO:0007409 axonogenesis 33.3333 6 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0051223 regulation of protein transport 33.3333 5 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:1901565 organonitrogen compound catabolic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
KIF22_HUMAN [view interactions] High throughput no no
NDEL1_HUMAN [view entry] [view interactions] High throughput yes yes
OAZ1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
NPSR1_HUMAN [view interactions] High throughput no no
SPAG6_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
E2AK4_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ARFP1_HUMAN [view interactions] High throughput no no
CH10_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
PIPNB_HUMAN [view interactions] High throughput no no
COTL1_HUMAN [view interactions] High throughput no yes