PLXA4_HUMAN
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PLXA4_HUMAN |
---|---|---|---|---|
GO:0017154 | semaphorin receptor activity | 41.1765 | 4 | yes |
GO:0017076 | purine nucleotide binding | 29.4118 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
GO:0016301 | kinase activity | 29.4118 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 29.4118 | 4 | no |
GO:0019900 | kinase binding | 23.5294 | 4 | no |
GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
GO:0004713 | protein tyrosine kinase activity | 23.5294 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PLXA4_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 88.2353 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 82.3529 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 70.5882 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 64.7059 | 4 | yes |
GO:0030030 | cell projection organization | 64.7059 | 4 | yes |
GO:0030155 | regulation of cell adhesion | 64.7059 | 4 | yes |
GO:0031175 | neuron projection development | 64.7059 | 6 | yes |
GO:0031344 | regulation of cell projection organization | 64.7059 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 64.7059 | 6 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 64.7059 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 64.7059 | 5 | yes |
GO:0022604 | regulation of cell morphogenesis | 58.8235 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 58.8235 | 4 | yes |
GO:0008360 | regulation of cell shape | 52.9412 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 52.9412 | 7 | yes |
GO:0045597 | positive regulation of cell differentiation | 52.9412 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 52.9412 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 52.9412 | 4 | yes |
GO:2000145 | regulation of cell motility | 52.9412 | 4 | yes |
GO:0007411 | axon guidance | 47.0588 | 8 | yes |
GO:0030334 | regulation of cell migration | 47.0588 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 47.0588 | 4 | yes |
GO:0060284 | regulation of cell development | 47.0588 | 5 | yes |
GO:0097485 | neuron projection guidance | 47.0588 | 7 | yes |
GO:0006996 | organelle organization | 47.0588 | 4 | no |
GO:0010720 | positive regulation of cell development | 41.1765 | 6 | yes |
GO:0050770 | regulation of axonogenesis | 41.1765 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 41.1765 | 4 | yes |
GO:0071526 | semaphorin-plexin signaling pathway | 41.1765 | 4 | yes |
GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 41.1765 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 41.1765 | 4 | yes |
GO:0033043 | regulation of organelle organization | 41.1765 | 5 | no |
GO:0001558 | regulation of cell growth | 35.2941 | 4 | yes |
GO:0030516 | regulation of axon extension | 35.2941 | 5 | yes |
GO:0032101 | regulation of response to external stimulus | 35.2941 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 35.2941 | 5 | yes |
GO:0048638 | regulation of developmental growth | 35.2941 | 4 | yes |
GO:0050767 | regulation of neurogenesis | 35.2941 | 6 | yes |
GO:0050769 | positive regulation of neurogenesis | 35.2941 | 6 | yes |
GO:0050772 | positive regulation of axonogenesis | 35.2941 | 6 | yes |
GO:0051960 | regulation of nervous system development | 35.2941 | 5 | yes |
GO:0051962 | positive regulation of nervous system development | 35.2941 | 5 | yes |
GO:0061387 | regulation of extent of cell growth | 35.2941 | 5 | yes |
GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 35.2941 | 6 | yes |
GO:0044087 | regulation of cellular component biogenesis | 35.2941 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 35.2941 | 5 | no |
GO:0051049 | regulation of transport | 35.2941 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 35.2941 | 6 | no |
GO:0007162 | negative regulation of cell adhesion | 29.4118 | 5 | yes |
GO:0021612 | facial nerve structural organization | 29.4118 | 4 | yes |
GO:0032990 | cell part morphogenesis | 29.4118 | 4 | yes |
GO:0048812 | neuron projection morphogenesis | 29.4118 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 29.4118 | 5 | yes |
GO:0050920 | regulation of chemotaxis | 29.4118 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 29.4118 | 6 | yes |
GO:0007010 | cytoskeleton organization | 29.4118 | 5 | no |
GO:0022607 | cellular component assembly | 29.4118 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 29.4118 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 29.4118 | 4 | no |
GO:0071310 | cellular response to organic substance | 29.4118 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 29.4118 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 29.4118 | 5 | no |
GO:0021637 | trigeminal nerve structural organization | 23.5294 | 4 | yes |
GO:0048841 | regulation of axon extension involved in axon guidance | 23.5294 | 6 | yes |
GO:0050919 | negative chemotaxis | 23.5294 | 4 | yes |
GO:0002684 | positive regulation of immune system process | 23.5294 | 4 | no |
GO:0010810 | regulation of cell-substrate adhesion | 23.5294 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 23.5294 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 23.5294 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
GO:0050776 | regulation of immune response | 23.5294 | 4 | no |
GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
GO:0060491 | regulation of cell projection assembly | 23.5294 | 5 | no |
GO:0061024 | membrane organization | 23.5294 | 4 | no |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 23.5294 | 6 | no |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 23.5294 | 6 | no |
GO:0001764 | neuron migration | 23.5294 | 4 | no |
GO:1990138 | neuron projection extension | 23.5294 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.5294 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 23.5294 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 23.5294 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 23.5294 | 4 | no |
GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
GO:0010646 | regulation of cell communication | 23.5294 | 4 | no |
GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 23.5294 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
GO:0060255 | regulation of macromolecule metabolic process | 23.5294 | 4 | no |
GO:0060548 | negative regulation of cell death | 23.5294 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 23.5294 | 4 | no |
GO:1901214 | regulation of neuron death | 23.5294 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 23.5294 | 5 | no |
GO:0007409 | axonogenesis | 17.6471 | 8 | yes |
GO:0060429 | epithelium development | 17.6471 | 4 | yes |
GO:0021615 | glossopharyngeal nerve morphogenesis | 11.7647 | 4 | yes |
GO:0021644 | vagus nerve morphogenesis | 11.7647 | 4 | yes |
GO:0021784 | postganglionic parasympathetic fiber development | 11.7647 | 5 | yes |
GO:0021793 | chemorepulsion of branchiomotor axon | 11.7647 | 6 | yes |
GO:0021952 | central nervous system projection neuron axonogenesis | 11.7647 | 10 | yes |
GO:0021955 | central nervous system neuron axonogenesis | 11.7647 | 9 | yes |
GO:0021960 | anterior commissure morphogenesis | 11.7647 | 11 | yes |
GO:0035050 | embryonic heart tube development | 11.7647 | 4 | yes |
GO:0048483 | autonomic nervous system development | 11.7647 | 4 | yes |
GO:0048485 | sympathetic nervous system development | 11.7647 | 4 | yes |
GO:0050923 | regulation of negative chemotaxis | 11.7647 | 5 | yes |
GO:0061643 | chemorepulsion of axon | 11.7647 | 5 | yes |
GO:0097492 | sympathetic neuron axon guidance | 11.7647 | 9 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PLXA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SEM6A_HUMAN | [view interactions] | Low throughput | no | yes |
FARP2_HUMAN | [view interactions] | Low throughput | no | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CLUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SEM3A_HUMAN | [view interactions] | Low throughput | no | no |
NRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
QORL1_HUMAN | [view interactions] | High throughput | no | yes |
TYRP2_HUMAN | [view interactions] | High throughput | no | no |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
NGB_HUMAN | [view interactions] | High throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RN149_HUMAN | [view interactions] | High throughput | no | no |
SGCZ_HUMAN | [view interactions] | High throughput | no | no |
SEM5B_HUMAN | [view interactions] | High throughput | no | yes |
SEM6B_HUMAN | [view interactions] | High throughput | no | yes |
SEM6D_HUMAN | [view interactions] | High throughput | no | no |
MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
NRP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RRAS_HUMAN | [view interactions] | Computational | no | yes |
PLXA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SEM3B_HUMAN | [view interactions] | Computational | no | yes |
SEM3D_HUMAN | [view interactions] | Computational | no | no |
SEM3C_HUMAN | [view interactions] | Computational | no | no |
FES_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SEM3G_HUMAN | [view interactions] | Computational | no | no |
DPYL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RND1_HUMAN | [view interactions] | Computational | no | no |
PLXA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MICA2_HUMAN | [view interactions] | Computational | no | yes |
PLXA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SEM7A_HUMAN | [view interactions] | Computational | no | yes |
SEM4D_HUMAN | [view interactions] | Computational | no | yes |
SEM6C_HUMAN | [view interactions] | Computational | no | no |
RHOD_HUMAN | [view interactions] | Computational | no | no |
LIMK1_HUMAN | [view interactions] | Computational | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |