Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLXA4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLXA4_HUMAN
GO:0005216 monoatomic ion channel activity 38.4615 4 no
GO:0015267 channel activity 38.4615 4 no
GO:0022890 inorganic cation transmembrane transporter activity 38.4615 4 no
GO:0005261 monoatomic cation channel activity 30.7692 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 30.7692 4 no
GO:0022836 gated channel activity 30.7692 5 no
GO:0046873 metal ion transmembrane transporter activity 30.7692 5 no
GO:0017154 semaphorin receptor activity 23.0769 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 23.0769 5 no
GO:0005262 calcium channel activity 23.0769 6 no
GO:0015085 calcium ion transmembrane transporter activity 23.0769 6 no
GO:0022832 voltage-gated channel activity 23.0769 6 no
GO:0022843 voltage-gated monoatomic cation channel activity 23.0769 6 no
GO:0043169 cation binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0030695 GTPase regulator activity 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PLXA4_HUMAN
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0048522 positive regulation of cellular process 53.8462 4 yes
GO:0030030 cell projection organization 46.1538 4 yes
GO:0048523 negative regulation of cellular process 46.1538 4 yes
GO:0051130 positive regulation of cellular component organization 46.1538 5 yes
GO:0010646 regulation of cell communication 46.1538 4 no
GO:0008104 protein localization 46.1538 4 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0022603 regulation of anatomical structure morphogenesis 38.4615 4 yes
GO:0031175 neuron projection development 38.4615 6 yes
GO:0031344 regulation of cell projection organization 38.4615 5 yes
GO:0048812 neuron projection morphogenesis 38.4615 5 yes
GO:0051240 positive regulation of multicellular organismal process 38.4615 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 yes
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 38.4615 4 yes
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0001558 regulation of cell growth 30.7692 4 yes
GO:0007409 axonogenesis 30.7692 6 yes
GO:0010975 regulation of neuron projection development 30.7692 7 yes
GO:0031346 positive regulation of cell projection organization 30.7692 6 yes
GO:0034330 cell junction organization 30.7692 4 yes
GO:0045595 regulation of cell differentiation 30.7692 4 yes
GO:0048638 regulation of developmental growth 30.7692 4 yes
GO:0050767 regulation of neurogenesis 30.7692 6 yes
GO:0050770 regulation of axonogenesis 30.7692 5 yes
GO:0050808 synapse organization 30.7692 5 yes
GO:0051094 positive regulation of developmental process 30.7692 4 yes
GO:0051960 regulation of nervous system development 30.7692 5 yes
GO:0060284 regulation of cell development 30.7692 5 yes
GO:2000026 regulation of multicellular organismal development 30.7692 4 yes
GO:0051049 regulation of transport 30.7692 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0009968 negative regulation of signal transduction 30.7692 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0010648 negative regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0023057 negative regulation of signaling 30.7692 4 no
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0043933 protein-containing complex organization 30.7692 4 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0048585 negative regulation of response to stimulus 30.7692 4 no
GO:0060255 regulation of macromolecule metabolic process 30.7692 4 no
GO:0065003 protein-containing complex assembly 30.7692 5 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0007411 axon guidance 23.0769 8 yes
GO:0008045 motor neuron axon guidance 23.0769 9 yes
GO:0010720 positive regulation of cell development 23.0769 6 yes
GO:0021612 facial nerve structural organization 23.0769 4 yes
GO:0021637 trigeminal nerve structural organization 23.0769 4 yes
GO:0021785 branchiomotor neuron axon guidance 23.0769 10 yes
GO:0022604 regulation of cell morphogenesis 23.0769 5 yes
GO:0030155 regulation of cell adhesion 23.0769 4 yes
GO:0030334 regulation of cell migration 23.0769 5 yes
GO:0030516 regulation of axon extension 23.0769 5 yes
GO:0032101 regulation of response to external stimulus 23.0769 4 yes
GO:0034331 cell junction maintenance 23.0769 5 yes
GO:0043954 cellular component maintenance 23.0769 4 yes
GO:0045597 positive regulation of cell differentiation 23.0769 5 yes
GO:0048841 regulation of axon extension involved in axon guidance 23.0769 6 yes
GO:0050769 positive regulation of neurogenesis 23.0769 6 yes
GO:0050772 positive regulation of axonogenesis 23.0769 6 yes
GO:0050920 regulation of chemotaxis 23.0769 4 yes
GO:0051962 positive regulation of nervous system development 23.0769 5 yes
GO:0061387 regulation of extent of cell growth 23.0769 5 yes
GO:0071526 semaphorin-plexin signaling pathway 23.0769 4 yes
GO:0097485 neuron projection guidance 23.0769 7 yes
GO:0099558 maintenance of synapse structure 23.0769 6 yes
GO:2000145 regulation of cell motility 23.0769 4 yes
GO:0001508 action potential 23.0769 4 no
GO:0006811 monoatomic ion transport 23.0769 4 no
GO:0006812 monoatomic cation transport 23.0769 5 no
GO:0030001 metal ion transport 23.0769 6 no
GO:0098655 monoatomic cation transmembrane transport 23.0769 4 no
GO:0098662 inorganic cation transmembrane transport 23.0769 4 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0015031 protein transport 23.0769 4 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0061024 membrane organization 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0006915 apoptotic process 23.0769 4 no
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0010468 regulation of gene expression 23.0769 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.0769 6 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0080090 regulation of primary metabolic process 23.0769 4 no
GO:0097193 intrinsic apoptotic signaling pathway 23.0769 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.0769 6 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0043524 negative regulation of neuron apoptotic process 23.0769 7 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.0769 5 no
GO:0007162 negative regulation of cell adhesion 15.3846 5 yes
GO:0021615 glossopharyngeal nerve morphogenesis 15.3846 4 yes
GO:0021644 vagus nerve morphogenesis 15.3846 4 yes
GO:0021784 postganglionic parasympathetic fiber development 15.3846 5 yes
GO:0021793 chemorepulsion of branchiomotor axon 15.3846 6 yes
GO:0021952 central nervous system projection neuron axonogenesis 15.3846 8 yes
GO:0021955 central nervous system neuron axonogenesis 15.3846 7 yes
GO:0021960 anterior commissure morphogenesis 15.3846 9 yes
GO:0035050 embryonic heart tube development 15.3846 4 yes
GO:0048483 autonomic nervous system development 15.3846 4 yes
GO:0048485 sympathetic nervous system development 15.3846 4 yes
GO:0050919 negative chemotaxis 15.3846 4 yes
GO:0050923 regulation of negative chemotaxis 15.3846 5 yes
GO:0060429 epithelium development 15.3846 4 yes
GO:0061643 chemorepulsion of axon 15.3846 5 yes
GO:0097492 sympathetic neuron axon guidance 15.3846 9 yes
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 15.3846 5 yes
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SEM6A_HUMAN [view interactions] Low throughput no yes
FARP2_HUMAN [view interactions] Low throughput no yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
SEM3A_HUMAN [view interactions] Low throughput no no
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLXA4_HUMAN [view entry] [view interactions] Low throughput yes no
MET_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
KTU_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
QORL1_HUMAN [view interactions] High throughput no yes
TYRP2_HUMAN [view interactions] High throughput no no
HIF1N_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
RN149_HUMAN [view interactions] High throughput no no
SGCZ_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
SEM5B_HUMAN [view interactions] High throughput no yes
SEM6B_HUMAN [view interactions] High throughput no yes
SEM6D_HUMAN [view interactions] High throughput no no
MTX1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes