Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RX1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RX1_HUMAN
GO:0000166 nucleotide binding 80.0000 4 yes
GO:0017076 purine nucleotide binding 80.0000 5 yes
GO:0032555 purine ribonucleotide binding 80.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 80.0000 4 yes
GO:0043168 anion binding 80.0000 4 yes
GO:0005524 ATP binding 60.0000 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 60.0000 4 yes
GO:0030554 adenyl nucleotide binding 60.0000 6 yes
GO:0032559 adenyl ribonucleotide binding 60.0000 5 yes
GO:0016462 pyrophosphatase activity 60.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 60.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 60.0000 6 no
GO:0005216 monoatomic ion channel activity 40.0000 4 yes
GO:0005261 monoatomic cation channel activity 40.0000 5 yes
GO:0015267 channel activity 40.0000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 40.0000 5 yes
GO:0022834 ligand-gated channel activity 40.0000 6 yes
GO:0022836 gated channel activity 40.0000 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 40.0000 6 yes
GO:0015081 sodium ion transmembrane transporter activity 40.0000 6 no
GO:0022890 inorganic cation transmembrane transporter activity 40.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 40.0000 5 no
GO:0016887 ATP hydrolysis activity 40.0000 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in P2RX1_HUMAN
GO:0006811 monoatomic ion transport 60.0000 4 yes
GO:0006812 monoatomic cation transport 60.0000 5 yes
GO:0010243 response to organonitrogen compound 60.0000 4 yes
GO:0030001 metal ion transport 60.0000 6 yes
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0051046 regulation of secretion 60.0000 5 yes
GO:0051049 regulation of transport 60.0000 4 yes
GO:0071702 organic substance transport 60.0000 4 yes
GO:0071705 nitrogen compound transport 60.0000 4 yes
GO:0098655 monoatomic cation transmembrane transport 60.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 60.0000 4 yes
GO:1903530 regulation of secretion by cell 60.0000 4 yes
GO:0006816 calcium ion transport 40.0000 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 40.0000 4 yes
GO:0010646 regulation of cell communication 40.0000 4 yes
GO:0014070 response to organic cyclic compound 40.0000 4 yes
GO:0017157 regulation of exocytosis 40.0000 5 yes
GO:0023061 signal release 40.0000 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 40.0000 5 yes
GO:0046903 secretion 40.0000 4 yes
GO:0046928 regulation of neurotransmitter secretion 40.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 yes
GO:0051050 positive regulation of transport 40.0000 4 yes
GO:0051588 regulation of neurotransmitter transport 40.0000 5 yes
GO:0055080 monoatomic cation homeostasis 40.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 40.0000 4 yes
GO:0070588 calcium ion transmembrane transport 40.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 yes
GO:0006814 sodium ion transport 40.0000 7 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0035725 sodium ion transmembrane transport 40.0000 5 no
GO:0043933 protein-containing complex organization 40.0000 4 no
GO:0048523 negative regulation of cellular process 40.0000 4 no
GO:0065003 protein-containing complex assembly 40.0000 5 no
GO:0008104 protein localization 40.0000 4 no
GO:0015031 protein transport 40.0000 4 no
GO:0050821 protein stabilization 40.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ATE1_HUMAN [view interactions] High throughput no yes
SGPL1_HUMAN [view interactions] High throughput no yes
FDFT_HUMAN [view interactions] High throughput no yes
ANM9_HUMAN [view interactions] High throughput no no
TMED8_HUMAN [view interactions] High throughput no no
GLBL2_HUMAN [view interactions] High throughput no no
ARL10_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
GMCL1_HUMAN [view interactions] High throughput no yes
P4K2A_HUMAN [view interactions] High throughput no yes
GLP3L_HUMAN [view interactions] High throughput no no
GOLP3_HUMAN [view interactions] High throughput no no
ARMX3_HUMAN [view interactions] High throughput no no
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
CYBC1_HUMAN [view interactions] High throughput no yes
IPIL1_HUMAN [view interactions] High throughput no no
COA1_HUMAN [view interactions] High throughput no yes
XYLK_HUMAN [view interactions] High throughput no yes
ASIC1_HUMAN [view entry] [view interactions] High throughput yes no
AT2C1_HUMAN [view interactions] High throughput no yes
SC11A_HUMAN [view interactions] High throughput no no
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no