P2RX1_HUMAN
Evidence for PS localization
Functions
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in P2RX1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 72.7273 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 72.7273 | 4 | yes |
| GO:0005216 | ion channel activity | 63.6364 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 63.6364 | 6 | yes |
| GO:0005261 | cation channel activity | 63.6364 | 5 | yes |
| GO:0015267 | channel activity | 63.6364 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 63.6364 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 63.6364 | 4 | yes |
| GO:0022834 | ligand-gated channel activity | 63.6364 | 6 | yes |
| GO:0022836 | gated channel activity | 63.6364 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 63.6364 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 63.6364 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 63.6364 | 6 | yes |
| GO:0005524 | ATP binding | 54.5455 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 54.5455 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 54.5455 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 54.5455 | 5 | no |
| GO:0005262 | calcium channel activity | 45.4545 | 6 | no |
| GO:0015085 | calcium ion transmembrane transporter activity | 45.4545 | 6 | no |
| GO:0099604 | ligand-gated calcium channel activity | 45.4545 | 7 | no |
| GO:0001614 | purinergic nucleotide receptor activity | 36.3636 | 5 | yes |
| GO:0016502 | nucleotide receptor activity | 36.3636 | 4 | yes |
| GO:0004970 | ionotropic glutamate receptor activity | 36.3636 | 5 | no |
| GO:0004972 | NMDA glutamate receptor activity | 36.3636 | 6 | no |
| GO:0005244 | voltage-gated ion channel activity | 36.3636 | 4 | no |
| GO:0008066 | glutamate receptor activity | 36.3636 | 4 | no |
| GO:0022824 | transmitter-gated ion channel activity | 36.3636 | 5 | no |
| GO:0022832 | voltage-gated channel activity | 36.3636 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 36.3636 | 4 | no |
| GO:0022843 | voltage-gated cation channel activity | 36.3636 | 5 | no |
| GO:0022849 | glutamate-gated calcium ion channel activity | 36.3636 | 6 | no |
| GO:0046872 | metal ion binding | 36.3636 | 4 | no |
| GO:0004931 | extracellularly ATP-gated cation channel activity | 27.2727 | 5 | yes |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 27.2727 | 7 | yes |
| GO:0035381 | ATP-gated ion channel activity | 27.2727 | 4 | yes |
| GO:0001540 | amyloid-beta binding | 27.2727 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in P2RX1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 81.8182 | 4 | yes |
| GO:0006811 | ion transport | 63.6364 | 4 | yes |
| GO:0006812 | cation transport | 63.6364 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 63.6364 | 4 | yes |
| GO:0010646 | regulation of cell communication | 63.6364 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 63.6364 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.5455 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 54.5455 | 5 | yes |
| GO:0051049 | regulation of transport | 54.5455 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 54.5455 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 54.5455 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 54.5455 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 54.5455 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 54.5455 | 5 | no |
| GO:0023056 | positive regulation of signaling | 54.5455 | 4 | no |
| GO:0030001 | metal ion transport | 54.5455 | 6 | no |
| GO:0098655 | cation transmembrane transport | 54.5455 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 54.5455 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 54.5455 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 45.4545 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.4545 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 45.4545 | 4 | yes |
| GO:0043269 | regulation of ion transport | 45.4545 | 5 | yes |
| GO:0051050 | positive regulation of transport | 45.4545 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 45.4545 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 45.4545 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 45.4545 | 4 | yes |
| GO:0006816 | calcium ion transport | 45.4545 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 45.4545 | 4 | no |
| GO:0070588 | calcium ion transmembrane transport | 45.4545 | 6 | no |
| GO:0008104 | protein localization | 45.4545 | 4 | no |
| GO:0010950 | positive regulation of endopeptidase activity | 36.3636 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 36.3636 | 6 | yes |
| GO:0014074 | response to purine-containing compound | 36.3636 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 36.3636 | 6 | yes |
| GO:0033198 | response to ATP | 36.3636 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 36.3636 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 36.3636 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 36.3636 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 36.3636 | 5 | yes |
| GO:0044057 | regulation of system process | 36.3636 | 4 | yes |
| GO:0045862 | positive regulation of proteolysis | 36.3636 | 7 | yes |
| GO:0046683 | response to organophosphorus | 36.3636 | 4 | yes |
| GO:0048878 | chemical homeostasis | 36.3636 | 4 | yes |
| GO:0050801 | ion homeostasis | 36.3636 | 5 | yes |
| GO:0051046 | regulation of secretion | 36.3636 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 36.3636 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 36.3636 | 5 | yes |
| GO:0052547 | regulation of peptidase activity | 36.3636 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 36.3636 | 6 | yes |
| GO:0055065 | metal ion homeostasis | 36.3636 | 7 | yes |
| GO:0055080 | cation homeostasis | 36.3636 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 36.3636 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 36.3636 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 36.3636 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 36.3636 | 7 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 36.3636 | 8 | yes |
| GO:0007420 | brain development | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 36.3636 | 5 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 36.3636 | 4 | no |
| GO:0060079 | excitatory postsynaptic potential | 36.3636 | 5 | no |
| GO:0097553 | calcium ion transmembrane import into cytosol | 36.3636 | 7 | no |
| GO:0098976 | excitatory chemical synaptic transmission | 36.3636 | 7 | no |
| GO:0071310 | cellular response to organic substance | 36.3636 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 27.2727 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 27.2727 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 27.2727 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 27.2727 | 5 | yes |
| GO:0030003 | cellular cation homeostasis | 27.2727 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 27.2727 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 27.2727 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 27.2727 | 7 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 27.2727 | 6 | yes |
| GO:0055074 | calcium ion homeostasis | 27.2727 | 8 | yes |
| GO:0060249 | anatomical structure homeostasis | 27.2727 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 27.2727 | 4 | yes |
| GO:0071702 | organic substance transport | 27.2727 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 27.2727 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 27.2727 | 7 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 27.2727 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 27.2727 | 7 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 27.2727 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.2727 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.2727 | 6 | no |
| GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.2727 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 27.2727 | 5 | no |
| GO:0050905 | neuromuscular process | 27.2727 | 4 | no |
| GO:0060291 | long-term synaptic potentiation | 27.2727 | 4 | no |
| GO:0072657 | protein localization to membrane | 27.2727 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 27.2727 | 5 | no |
| GO:0007600 | sensory perception | 27.2727 | 4 | no |
| GO:0019233 | sensory perception of pain | 27.2727 | 5 | no |
| GO:0071407 | cellular response to organic cyclic compound | 27.2727 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 27.2727 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 27.2727 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 27.2727 | 4 | no |
| GO:0001508 | action potential | 18.1818 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 18.1818 | 4 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 18.1818 | 7 | yes |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18.1818 | 10 | yes |
| GO:0006937 | regulation of muscle contraction | 18.1818 | 6 | yes |
| GO:0019228 | neuronal action potential | 18.1818 | 5 | yes |
| GO:0035150 | regulation of tube size | 18.1818 | 4 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 18.1818 | 7 | yes |
| GO:0035296 | regulation of tube diameter | 18.1818 | 5 | yes |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18.1818 | 9 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18.1818 | 8 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 18.1818 | 4 | yes |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 18.1818 | 8 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 18.1818 | 5 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 18.1818 | 6 | yes |
| GO:0090257 | regulation of muscle system process | 18.1818 | 5 | yes |
| GO:0097746 | blood vessel diameter maintenance | 18.1818 | 5 | yes |
| GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration | 18.1818 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 18.1818 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 18.1818 | 5 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 18.1818 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMX3_HUMAN | [view interactions] | High throughput | no | no |
| GOLP3_HUMAN | [view interactions] | High throughput | no | no |
| GLP3L_HUMAN | [view interactions] | High throughput | no | no |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| GLBL2_HUMAN | [view interactions] | High throughput | no | no |
| TMED8_HUMAN | [view interactions] | High throughput | no | no |
| ANM9_HUMAN | [view interactions] | High throughput | no | no |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| SGPL1_HUMAN | [view interactions] | High throughput | no | yes |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| IPIL1_HUMAN | [view interactions] | High throughput | no | no |
| COA1_HUMAN | [view interactions] | High throughput | no | yes |
| XYLK_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC1_HUMAN | [view interactions] | High throughput | no | no |
| AT2C1_HUMAN | [view interactions] | High throughput | no | yes |
| SC11A_HUMAN | [view interactions] | High throughput | no | no |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P2RX7_HUMAN | [view interactions] | Computational | no | yes |
| P2RX5_HUMAN | [view interactions] | Computational | no | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P2RX6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| P2Y12_HUMAN | [view interactions] | Computational | no | no |
| P2RY1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| P2Y14_HUMAN | [view interactions] | Computational | no | yes |
| P2RX4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P2RY2_HUMAN | [view interactions] | Computational | no | no |
| P2Y11_HUMAN | [view interactions] | Computational | no | yes |
| P2RX3_HUMAN | [view interactions] | Computational | no | no |
| P2RY4_HUMAN | [view interactions] | Computational | no | no |
| P2Y13_HUMAN | [view interactions] | Computational | no | yes |
| P2RY6_HUMAN | [view interactions] | Computational | no | no |