GBRG3_HUMAN
Evidence for PS localization
Functions
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBRG3_HUMAN |
|---|---|---|---|---|
| GO:0004890 | GABA-A receptor activity | 66.6667 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 66.6667 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 66.6667 | 6 | yes |
| GO:0005237 | inhibitory extracellular ligand-gated monoatomic ion channel activity | 66.6667 | 7 | yes |
| GO:0005253 | monoatomic anion channel activity | 66.6667 | 5 | yes |
| GO:0005254 | chloride channel activity | 66.6667 | 6 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015103 | inorganic anion transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015108 | chloride transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0015267 | channel activity | 66.6667 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 66.6667 | 5 | yes |
| GO:0016917 | GABA receptor activity | 66.6667 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 66.6667 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 66.6667 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 66.6667 | 4 | yes |
| GO:0022836 | gated channel activity | 66.6667 | 5 | yes |
| GO:0022851 | GABA-gated chloride ion channel activity | 66.6667 | 6 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 66.6667 | 4 | yes |
| GO:0099095 | ligand-gated monoatomic anion channel activity | 66.6667 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 66.6667 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 66.6667 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBRG3_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 66.6667 | 4 | yes |
| GO:0006820 | monoatomic anion transport | 66.6667 | 5 | yes |
| GO:0006821 | chloride transport | 66.6667 | 5 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 66.6667 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 66.6667 | 7 | yes |
| GO:0015698 | inorganic anion transport | 66.6667 | 4 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 66.6667 | 8 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 66.6667 | 4 | yes |
| GO:0098656 | monoatomic anion transmembrane transport | 66.6667 | 4 | yes |
| GO:0098661 | inorganic anion transmembrane transport | 66.6667 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 66.6667 | 6 | yes |
| GO:0099536 | synaptic signaling | 66.6667 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 66.6667 | 5 | yes |
| GO:1902476 | chloride transmembrane transport | 66.6667 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |