Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE8A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed). Binding to RAF1 reduces RAF1 Ser-259 inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE8A_HUMAN
GO:0000166 nucleotide binding 66.6667 4 no
GO:0017076 purine nucleotide binding 66.6667 5 no
GO:0032555 purine ribonucleotide binding 66.6667 4 no
GO:0043168 anion binding 66.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 no
GO:0019001 guanyl nucleotide binding 55.5556 6 no
GO:0032561 guanyl ribonucleotide binding 55.5556 5 no
GO:0003924 GTPase activity 44.4444 7 no
GO:0005525 GTP binding 44.4444 5 no
GO:0016462 pyrophosphatase activity 44.4444 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 44.4444 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 44.4444 6 no
GO:0004112 cyclic-nucleotide phosphodiesterase activity 22.2222 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 22.2222 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 22.2222 8 yes
GO:0008081 phosphoric diester hydrolase activity 22.2222 5 yes
GO:0019887 protein kinase regulator activity 22.2222 4 yes
GO:0019900 kinase binding 22.2222 4 yes
GO:0042578 phosphoric ester hydrolase activity 22.2222 4 yes
GO:0043169 cation binding 22.2222 4 yes
GO:0046872 metal ion binding 22.2222 5 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 22.2222 8 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0019003 GDP binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PDE8A_HUMAN
GO:0009966 regulation of signal transduction 88.8889 4 yes
GO:0010646 regulation of cell communication 88.8889 4 yes
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0048584 positive regulation of response to stimulus 77.7778 4 yes
GO:0009967 positive regulation of signal transduction 66.6667 5 yes
GO:0010647 positive regulation of cell communication 66.6667 5 yes
GO:0023056 positive regulation of signaling 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 yes
GO:0009889 regulation of biosynthetic process 55.5556 4 yes
GO:0010468 regulation of gene expression 55.5556 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 yes
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 yes
GO:1902533 positive regulation of intracellular signal transduction 55.5556 6 yes
GO:0002684 positive regulation of immune system process 55.5556 4 no
GO:0009893 positive regulation of metabolic process 55.5556 4 no
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 no
GO:0032101 regulation of response to external stimulus 55.5556 4 no
GO:0032103 positive regulation of response to external stimulus 55.5556 5 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051049 regulation of transport 55.5556 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0051247 positive regulation of protein metabolic process 55.5556 6 no
GO:0060627 regulation of vesicle-mediated transport 55.5556 4 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0001934 positive regulation of protein phosphorylation 44.4444 8 no
GO:0010562 positive regulation of phosphorus metabolic process 44.4444 6 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0030030 cell projection organization 44.4444 4 no
GO:0030155 regulation of cell adhesion 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0031401 positive regulation of protein modification process 44.4444 7 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0042327 positive regulation of phosphorylation 44.4444 8 no
GO:0045937 positive regulation of phosphate metabolic process 44.4444 7 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0071702 organic substance transport 44.4444 4 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 no
GO:0044089 positive regulation of cellular component biogenesis 44.4444 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 33.3333 6 no
GO:0007264 small GTPase-mediated signal transduction 33.3333 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:1901565 organonitrogen compound catabolic process 33.3333 4 yes
GO:0001817 regulation of cytokine production 33.3333 4 no
GO:0002685 regulation of leukocyte migration 33.3333 4 no
GO:0002688 regulation of leukocyte chemotaxis 33.3333 5 no
GO:0002831 regulation of response to biotic stimulus 33.3333 4 no
GO:0002833 positive regulation of response to biotic stimulus 33.3333 5 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0017157 regulation of exocytosis 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0031347 regulation of defense response 33.3333 5 no
GO:0031349 positive regulation of defense response 33.3333 5 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0045088 regulation of innate immune response 33.3333 5 no
GO:0045089 positive regulation of innate immune response 33.3333 6 no
GO:0045785 positive regulation of cell adhesion 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0050778 positive regulation of immune response 33.3333 5 no
GO:0050920 regulation of chemotaxis 33.3333 4 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0062207 regulation of pattern recognition receptor signaling pathway 33.3333 5 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:0001894 tissue homeostasis 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0061024 membrane organization 33.3333 4 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0072659 protein localization to plasma membrane 33.3333 5 no
GO:1990778 protein localization to cell periphery 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0035023 regulation of Rho protein signal transduction 22.2222 7 no
GO:0048259 regulation of receptor-mediated endocytosis 22.2222 6 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0062208 positive regulation of pattern recognition receptor signaling pathway 22.2222 6 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:1901890 positive regulation of cell junction assembly 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:0002687 positive regulation of leukocyte migration 22.2222 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 22.2222 6 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0007015 actin filament organization 22.2222 5 no
GO:0010310 regulation of hydrogen peroxide metabolic process 22.2222 6 no
GO:0010591 regulation of lamellipodium assembly 22.2222 7 no
GO:0010592 positive regulation of lamellipodium assembly 22.2222 7 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0016601 Rac protein signal transduction 22.2222 6 no
GO:0030031 cell projection assembly 22.2222 5 no
GO:0050921 positive regulation of chemotaxis 22.2222 5 no
GO:0051057 positive regulation of small GTPase mediated signal transduction 22.2222 7 no
GO:0060263 regulation of respiratory burst 22.2222 4 no
GO:0060491 regulation of cell projection assembly 22.2222 5 no
GO:0071622 regulation of granulocyte chemotaxis 22.2222 6 no
GO:0071624 positive regulation of granulocyte chemotaxis 22.2222 7 no
GO:0090022 regulation of neutrophil chemotaxis 22.2222 6 no
GO:0090023 positive regulation of neutrophil chemotaxis 22.2222 7 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 22.2222 6 no
GO:1902622 regulation of neutrophil migration 22.2222 5 no
GO:1902624 positive regulation of neutrophil migration 22.2222 6 no
GO:1902743 regulation of lamellipodium organization 22.2222 7 no
GO:1902745 positive regulation of lamellipodium organization 22.2222 7 no
GO:2000377 regulation of reactive oxygen species metabolic process 22.2222 5 no
GO:0006163 purine nucleotide metabolic process 22.2222 5 yes
GO:0006195 purine nucleotide catabolic process 22.2222 6 yes
GO:0006198 cAMP catabolic process 22.2222 7 yes
GO:0006753 nucleoside phosphate metabolic process 22.2222 4 yes
GO:0009117 nucleotide metabolic process 22.2222 5 yes
GO:0009150 purine ribonucleotide metabolic process 22.2222 6 yes
GO:0009154 purine ribonucleotide catabolic process 22.2222 6 yes
GO:0009166 nucleotide catabolic process 22.2222 6 yes
GO:0009187 cyclic nucleotide metabolic process 22.2222 6 yes
GO:0009214 cyclic nucleotide catabolic process 22.2222 7 yes
GO:0009259 ribonucleotide metabolic process 22.2222 5 yes
GO:0009261 ribonucleotide catabolic process 22.2222 5 yes
GO:0019693 ribose phosphate metabolic process 22.2222 4 yes
GO:0034655 nucleobase-containing compound catabolic process 22.2222 4 yes
GO:0043408 regulation of MAPK cascade 22.2222 6 yes
GO:0046058 cAMP metabolic process 22.2222 7 yes
GO:0046434 organophosphate catabolic process 22.2222 4 yes
GO:0052652 cyclic purine nucleotide metabolic process 22.2222 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 yes
GO:0072521 purine-containing compound metabolic process 22.2222 4 yes
GO:0072523 purine-containing compound catabolic process 22.2222 5 yes
GO:1901136 carbohydrate derivative catabolic process 22.2222 4 yes
GO:1901292 nucleoside phosphate catabolic process 22.2222 5 yes
GO:1901361 organic cyclic compound catabolic process 22.2222 4 yes
GO:0002694 regulation of leukocyte activation 22.2222 4 no
GO:0002697 regulation of immune effector process 22.2222 4 no
GO:0002703 regulation of leukocyte mediated immunity 22.2222 5 no
GO:0002886 regulation of myeloid leukocyte mediated immunity 22.2222 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0014013 regulation of gliogenesis 22.2222 7 no
GO:0014015 positive regulation of gliogenesis 22.2222 7 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0021782 glial cell development 22.2222 4 no
GO:0022407 regulation of cell-cell adhesion 22.2222 5 no
GO:0022409 positive regulation of cell-cell adhesion 22.2222 6 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0032944 regulation of mononuclear cell proliferation 22.2222 6 no
GO:0036211 protein modification process 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0043300 regulation of leukocyte degranulation 22.2222 5 no
GO:0043304 regulation of mast cell degranulation 22.2222 6 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045596 negative regulation of cell differentiation 22.2222 5 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0050670 regulation of lymphocyte proliferation 22.2222 6 no
GO:0050767 regulation of neurogenesis 22.2222 6 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0050863 regulation of T cell activation 22.2222 6 no
GO:0050865 regulation of cell activation 22.2222 4 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051249 regulation of lymphocyte activation 22.2222 5 no
GO:0051960 regulation of nervous system development 22.2222 5 no
GO:0051962 positive regulation of nervous system development 22.2222 5 no
GO:0060251 regulation of glial cell proliferation 22.2222 5 no
GO:0060252 positive regulation of glial cell proliferation 22.2222 6 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:0070663 regulation of leukocyte proliferation 22.2222 5 no
GO:0070665 positive regulation of leukocyte proliferation 22.2222 6 no
GO:0070666 regulation of mast cell proliferation 22.2222 6 no
GO:0070668 positive regulation of mast cell proliferation 22.2222 7 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0140546 defense response to symbiont 22.2222 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:1903305 regulation of regulated secretory pathway 22.2222 6 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0045453 bone resorption 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0022411 cellular component disassembly 22.2222 4 no
GO:0030100 regulation of endocytosis 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
TRIB1_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
NPHP3_HUMAN [view interactions] High throughput no yes
U119A_HUMAN [view interactions] High throughput no no
NR1H3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
PDE8B_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
CNGA1_HUMAN [view interactions] High throughput no no
CNGA3_HUMAN [view interactions] High throughput no no
CP2U1_HUMAN [view interactions] High throughput no yes
CP4B1_HUMAN [view interactions] High throughput no no
CP4F3_HUMAN [view interactions] High throughput no no
PDE10_HUMAN [view entry] [view interactions] High throughput yes no
LAT1_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes