Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDE8A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed). Binding to RAF1 reduces RAF1 Ser-259 inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PDE8A_HUMAN
GO:0017076 purine nucleotide binding 70.0000 4 no
GO:0032555 purine ribonucleotide binding 70.0000 4 no
GO:0019001 guanyl nucleotide binding 60.0000 5 no
GO:0032561 guanyl ribonucleotide binding 60.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 60.0000 4 no
GO:0005525 GTP binding 50.0000 5 no
GO:0003924 GTPase activity 40.0000 7 no
GO:0016462 pyrophosphatase activity 40.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 40.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 40.0000 6 no
GO:0019900 kinase binding 30.0000 4 yes
GO:0030554 adenyl nucleotide binding 30.0000 5 no
GO:0032559 adenyl ribonucleotide binding 30.0000 5 no
GO:0004112 cyclic-nucleotide phosphodiesterase activity 20.0000 6 yes
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity 20.0000 7 yes
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity 20.0000 8 yes
GO:0008081 phosphoric diester hydrolase activity 20.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 20.0000 4 yes
GO:0046872 metal ion binding 20.0000 4 yes
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity 20.0000 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDE8A_HUMAN
GO:0009966 regulation of signal transduction 80.0000 4 yes
GO:0010646 regulation of cell communication 80.0000 4 yes
GO:0048522 positive regulation of cellular process 80.0000 4 yes
GO:0048584 positive regulation of response to stimulus 70.0000 4 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0009967 positive regulation of signal transduction 60.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 yes
GO:0010647 positive regulation of cell communication 60.0000 5 yes
GO:0023056 positive regulation of signaling 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 60.0000 5 yes
GO:0051246 regulation of protein metabolic process 60.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 60.0000 6 yes
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 60.0000 5 yes
GO:0010468 regulation of gene expression 50.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0031399 regulation of protein modification process 50.0000 6 yes
GO:0031401 positive regulation of protein modification process 50.0000 7 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0051049 regulation of transport 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 50.0000 4 no
GO:0001932 regulation of protein phosphorylation 50.0000 7 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 yes
GO:0048585 negative regulation of response to stimulus 40.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 40.0000 6 yes
GO:0006996 organelle organization 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0030030 cell projection organization 40.0000 4 no
GO:0030155 regulation of cell adhesion 40.0000 4 no
GO:0044087 regulation of cellular component biogenesis 40.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 40.0000 5 no
GO:0050776 regulation of immune response 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0061024 membrane organization 40.0000 4 no
GO:0009117 nucleotide metabolic process 30.0000 5 yes
GO:0009150 purine ribonucleotide metabolic process 30.0000 6 yes
GO:0009259 ribonucleotide metabolic process 30.0000 5 yes
GO:0009889 regulation of biosynthetic process 30.0000 4 yes
GO:0010941 regulation of cell death 30.0000 4 yes
GO:0019693 ribose phosphate metabolic process 30.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 yes
GO:0071310 cellular response to organic substance 30.0000 4 yes
GO:0072521 purine-containing compound metabolic process 30.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 30.0000 4 yes
GO:0002684 positive regulation of immune system process 30.0000 4 no
GO:0002685 regulation of leukocyte migration 30.0000 4 no
GO:0002688 regulation of leukocyte chemotaxis 30.0000 5 no
GO:0007010 cytoskeleton organization 30.0000 5 no
GO:0007264 small GTPase mediated signal transduction 30.0000 4 no
GO:0007265 Ras protein signal transduction 30.0000 5 no
GO:0008284 positive regulation of cell population proliferation 30.0000 5 no
GO:0017157 regulation of exocytosis 30.0000 5 no
GO:0030334 regulation of cell migration 30.0000 5 no
GO:0030335 positive regulation of cell migration 30.0000 6 no
GO:0031175 neuron projection development 30.0000 6 no
GO:0031344 regulation of cell projection organization 30.0000 5 no
GO:0031346 positive regulation of cell projection organization 30.0000 6 no
GO:0032101 regulation of response to external stimulus 30.0000 4 no
GO:0032103 positive regulation of response to external stimulus 30.0000 5 no
GO:0033043 regulation of organelle organization 30.0000 5 no
GO:0040017 positive regulation of locomotion 30.0000 4 no
GO:0042127 regulation of cell population proliferation 30.0000 4 no
GO:0050920 regulation of chemotaxis 30.0000 4 no
GO:0051046 regulation of secretion 30.0000 5 no
GO:0051050 positive regulation of transport 30.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 30.0000 5 no
GO:1903530 regulation of secretion by cell 30.0000 4 no
GO:2000145 regulation of cell motility 30.0000 4 no
GO:2000147 positive regulation of cell motility 30.0000 5 no
GO:0001817 regulation of cytokine production 30.0000 4 no
GO:0045785 positive regulation of cell adhesion 30.0000 5 no
GO:0046578 regulation of Ras protein signal transduction 30.0000 7 no
GO:0051056 regulation of small GTPase mediated signal transduction 30.0000 6 no
GO:0051094 positive regulation of developmental process 30.0000 4 no
GO:0062207 regulation of pattern recognition receptor signaling pathway 30.0000 5 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0045595 regulation of cell differentiation 30.0000 4 no
GO:0009968 negative regulation of signal transduction 30.0000 5 no
GO:0010648 negative regulation of cell communication 30.0000 5 no
GO:0023057 negative regulation of signaling 30.0000 4 no
GO:0006163 purine nucleotide metabolic process 30.0000 5 yes
GO:0006753 nucleoside phosphate metabolic process 30.0000 4 yes
GO:0009154 purine ribonucleotide catabolic process 20.0000 6 yes
GO:0009166 nucleotide catabolic process 20.0000 6 yes
GO:0009187 cyclic nucleotide metabolic process 20.0000 6 yes
GO:0009214 cyclic nucleotide catabolic process 20.0000 7 yes
GO:0009261 ribonucleotide catabolic process 20.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 20.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.0000 5 yes
GO:0019439 aromatic compound catabolic process 20.0000 4 yes
GO:0034655 nucleobase-containing compound catabolic process 20.0000 4 yes
GO:0043408 regulation of MAPK cascade 20.0000 6 yes
GO:0044270 cellular nitrogen compound catabolic process 20.0000 4 yes
GO:0046058 cAMP metabolic process 20.0000 7 yes
GO:0046434 organophosphate catabolic process 20.0000 4 yes
GO:0046700 heterocycle catabolic process 20.0000 4 yes
GO:0051252 regulation of RNA metabolic process 20.0000 5 yes
GO:0060548 negative regulation of cell death 20.0000 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 20.0000 7 yes
GO:0072523 purine-containing compound catabolic process 20.0000 5 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:0080135 regulation of cellular response to stress 20.0000 4 yes
GO:1901136 carbohydrate derivative catabolic process 20.0000 4 yes
GO:1901292 nucleoside phosphate catabolic process 20.0000 5 yes
GO:1901361 organic cyclic compound catabolic process 20.0000 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 20.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 20.0000 6 yes
GO:0006195 purine nucleotide catabolic process 20.0000 6 yes
GO:0006198 cAMP catabolic process 20.0000 7 yes
GO:0006355 regulation of DNA-templated transcription 20.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
TRIB1_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
NPHP3_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
U119A_HUMAN [view interactions] High throughput no no
NR1H3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
PDE8B_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
CNGA1_HUMAN [view interactions] High throughput no no
CNGA3_HUMAN [view interactions] High throughput no no
CP2U1_HUMAN [view interactions] High throughput no yes
CP4B1_HUMAN [view interactions] High throughput no no
CP4F3_HUMAN [view interactions] High throughput no no
PDE10_HUMAN [view entry] [view interactions] High throughput yes no
LAT1_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
PUR8_HUMAN [view interactions] Computational no yes
APT_HUMAN [view interactions] Computational no yes
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
DCK_HUMAN [view interactions] Computational no no