Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRR7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner . Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed). Might play a redundant role in the regulation of T cell receptor signaling (PubMed). Might promote apoptosis in T cells (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PRR7_HUMAN
GO:0019900 kinase binding 37.5000 4 yes
GO:0019901 protein kinase binding 37.5000 5 yes
GO:0031406 carboxylic acid binding 37.5000 4 yes
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0001540 amyloid-beta binding 25.0000 4 no
GO:0004970 ionotropic glutamate receptor activity 25.0000 5 no
GO:0004972 NMDA glutamate receptor activity 25.0000 6 no
GO:0005216 ion channel activity 25.0000 4 no
GO:0005230 extracellular ligand-gated ion channel activity 25.0000 6 no
GO:0005244 voltage-gated ion channel activity 25.0000 4 no
GO:0005261 cation channel activity 25.0000 5 no
GO:0005262 calcium channel activity 25.0000 6 no
GO:0008066 glutamate receptor activity 25.0000 4 no
GO:0008324 cation transmembrane transporter activity 25.0000 4 no
GO:0015085 calcium ion transmembrane transporter activity 25.0000 6 no
GO:0015267 channel activity 25.0000 4 no
GO:0015276 ligand-gated ion channel activity 25.0000 5 no
GO:0016594 glycine binding 25.0000 4 no
GO:0016595 glutamate binding 25.0000 5 no
GO:0016597 amino acid binding 25.0000 4 no
GO:0022824 transmitter-gated ion channel activity 25.0000 5 no
GO:0022832 voltage-gated channel activity 25.0000 6 no
GO:0022834 ligand-gated channel activity 25.0000 6 no
GO:0022835 transmitter-gated channel activity 25.0000 4 no
GO:0022836 gated channel activity 25.0000 5 no
GO:0022843 voltage-gated cation channel activity 25.0000 5 no
GO:0022849 glutamate-gated calcium ion channel activity 25.0000 6 no
GO:0022890 inorganic cation transmembrane transporter activity 25.0000 4 no
GO:0046872 metal ion binding 25.0000 4 no
GO:0046873 metal ion transmembrane transporter activity 25.0000 5 no
GO:0099094 ligand-gated cation channel activity 25.0000 6 no
GO:0099604 ligand-gated calcium channel activity 25.0000 7 no
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0031690 adrenergic receptor binding 25.0000 5 no
GO:0031698 beta-2 adrenergic receptor binding 25.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in PRR7_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 87.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 87.5000 4 yes
GO:0080090 regulation of primary metabolic process 87.5000 4 yes
GO:0009893 positive regulation of metabolic process 75.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 75.0000 5 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 75.0000 5 yes
GO:0051246 regulation of protein metabolic process 75.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 75.0000 6 yes
GO:0043085 positive regulation of catalytic activity 62.5000 4 yes
GO:0031323 regulation of cellular metabolic process 62.5000 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0060341 regulation of cellular localization 50.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 37.5000 4 no
GO:0050807 regulation of synapse organization 37.5000 5 no
GO:0051051 negative regulation of transport 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0009892 negative regulation of metabolic process 37.5000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 yes
GO:0010950 positive regulation of endopeptidase activity 37.5000 7 yes
GO:0010952 positive regulation of peptidase activity 37.5000 6 yes
GO:0030162 regulation of proteolysis 37.5000 6 yes
GO:0031399 regulation of protein modification process 37.5000 6 yes
GO:0045862 positive regulation of proteolysis 37.5000 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 yes
GO:0051336 regulation of hydrolase activity 37.5000 4 yes
GO:0051345 positive regulation of hydrolase activity 37.5000 5 yes
GO:0052547 regulation of peptidase activity 37.5000 5 yes
GO:0052548 regulation of endopeptidase activity 37.5000 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 37.5000 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 37.5000 8 yes
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0007268 chemical synaptic transmission 37.5000 6 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0034762 regulation of transmembrane transport 37.5000 4 no
GO:0034765 regulation of ion transmembrane transport 37.5000 5 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0050890 cognition 37.5000 4 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0098916 anterograde trans-synaptic signaling 37.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0099537 trans-synaptic signaling 37.5000 4 no
GO:1904062 regulation of cation transmembrane transport 37.5000 6 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0061097 regulation of protein tyrosine kinase activity 25.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0008104 protein localization 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0050806 positive regulation of synaptic transmission 25.0000 5 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0006508 proteolysis 25.0000 4 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0016567 protein ubiquitination 25.0000 7 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0032446 protein modification by small protein conjugation 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0044265 cellular macromolecule catabolic process 25.0000 4 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0070647 protein modification by small protein conjugation or removal 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 yes
GO:0010942 positive regulation of cell death 25.0000 5 yes
GO:0031400 negative regulation of protein modification process 25.0000 7 yes
GO:0051248 negative regulation of protein metabolic process 25.0000 6 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0006811 ion transport 25.0000 4 no
GO:0006812 cation transport 25.0000 5 no
GO:0006816 calcium ion transport 25.0000 7 no
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0007420 brain development 25.0000 4 no
GO:0007612 learning 25.0000 4 no
GO:0009416 response to light stimulus 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0030001 metal ion transport 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045471 response to ethanol 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051259 protein complex oligomerization 25.0000 6 no
GO:0051262 protein tetramerization 25.0000 7 no
GO:0051290 protein heterotetramerization 25.0000 8 no
GO:0051291 protein heterooligomerization 25.0000 7 no
GO:0060078 regulation of postsynaptic membrane potential 25.0000 4 no
GO:0060079 excitatory postsynaptic potential 25.0000 5 no
GO:0070588 calcium ion transmembrane transport 25.0000 6 no
GO:0097305 response to alcohol 25.0000 4 no
GO:0097553 calcium ion transmembrane import into cytosol 25.0000 7 no
GO:0098655 cation transmembrane transport 25.0000 4 no
GO:0098660 inorganic ion transmembrane transport 25.0000 4 no
GO:0098662 inorganic cation transmembrane transport 25.0000 5 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:0098976 excitatory chemical synaptic transmission 25.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN785_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PRR9_HUMAN [view interactions] Computational no yes