PCDH8_HUMAN
Evidence for PS localization
Functions
Calcium-dependent cell-adhesion protein . May play a role in activity-induced synaptic reorganization underlying long term memory . Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004108 | LIG_WRC_WIRS_1 | LIG | 984 | 989 | - |
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PCDH8_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 100.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |