Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PCDH8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Calcium-dependent cell-adhesion protein . May play a role in activity-induced synaptic reorganization underlying long term memory . Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004108 LIG_WRC_WIRS_1 LIG 984 989 -
ELMI004108 LIG_WRC_WIRS_1 LIG 984 989 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PCDH8_HUMAN
GO:0043168 anion binding 42.8571 4 no
GO:0005261 monoatomic cation channel activity 28.5714 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 28.5714 4 no
GO:0015267 channel activity 28.5714 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 28.5714 5 no
GO:0022832 voltage-gated channel activity 28.5714 6 no
GO:0022834 ligand-gated channel activity 28.5714 6 no
GO:0022836 gated channel activity 28.5714 5 no
GO:0022890 inorganic cation transmembrane transporter activity 28.5714 4 no
GO:0046873 metal ion transmembrane transporter activity 28.5714 5 no
GO:0099094 ligand-gated monoatomic cation channel activity 28.5714 6 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0005216 monoatomic ion channel activity 28.5714 4 no
GO:0005244 voltage-gated monoatomic ion channel activity 28.5714 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PCDH8_HUMAN
GO:0051128 regulation of cellular component organization 85.7143 4 yes
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 yes
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 yes
GO:0031344 regulation of cell projection organization 57.1429 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 57.1429 6 no
GO:0008104 protein localization 57.1429 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0050890 cognition 42.8571 4 no
GO:0010975 regulation of neuron projection development 42.8571 7 no
GO:0022603 regulation of anatomical structure morphogenesis 42.8571 4 no
GO:0030030 cell projection organization 42.8571 4 no
GO:0048812 neuron projection morphogenesis 42.8571 5 no
GO:0120036 plasma membrane bounded cell projection organization 42.8571 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 42.8571 4 no
GO:0007268 chemical synaptic transmission 28.5714 7 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 28.5714 4 yes
GO:0098916 anterograde trans-synaptic signaling 28.5714 6 yes
GO:0099536 synaptic signaling 28.5714 4 yes
GO:0099537 trans-synaptic signaling 28.5714 5 yes
GO:0006811 monoatomic ion transport 28.5714 4 no
GO:0006812 monoatomic cation transport 28.5714 5 no
GO:0007420 brain development 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0030001 metal ion transport 28.5714 6 no
GO:0031345 negative regulation of cell projection organization 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051259 protein complex oligomerization 28.5714 6 no
GO:0051262 protein tetramerization 28.5714 7 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 no
GO:0098662 inorganic cation transmembrane transport 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0007612 learning 28.5714 4 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0050770 regulation of axonogenesis 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBQL4_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes