Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HCN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
126 Ser Leu Febrileseizures,familial,2(FEB2) -
246 Val Met Epilepsy,idiopathicgeneralized17(EIG17) -
515 Glu Lys Epilepsy,idiopathicgeneralized17(EIG17) -
632 Ser Trp Epilepsy,idiopathicgeneralized17(EIG17) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HCN2_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 yes
GO:0032555 purine ribonucleotide binding 50.0000 4 yes
GO:0008324 cation transmembrane transporter activity 43.7500 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 43.7500 4 yes
GO:0030554 adenyl nucleotide binding 43.7500 5 yes
GO:0032559 adenyl ribonucleotide binding 43.7500 5 yes
GO:0005216 ion channel activity 37.5000 4 yes
GO:0015267 channel activity 37.5000 4 yes
GO:0046873 metal ion transmembrane transporter activity 37.5000 5 yes
GO:0046872 metal ion binding 37.5000 4 no
GO:0005261 cation channel activity 31.2500 5 yes
GO:0022836 gated channel activity 31.2500 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 31.2500 4 no
GO:0005217 intracellular ligand-gated ion channel activity 25.0000 6 yes
GO:0005221 intracellular cyclic nucleotide activated cation channel activity 25.0000 7 yes
GO:0015081 sodium ion transmembrane transporter activity 25.0000 6 yes
GO:0015276 ligand-gated ion channel activity 25.0000 5 yes
GO:0022834 ligand-gated channel activity 25.0000 6 yes
GO:0043855 cyclic nucleotide-gated ion channel activity 25.0000 6 yes
GO:0099094 ligand-gated cation channel activity 25.0000 6 yes
GO:0005524 ATP binding 25.0000 5 no
GO:0046875 ephrin receptor binding 25.0000 4 no
GO:0070851 growth factor receptor binding 25.0000 4 no
GO:0005222 intracellular cAMP-activated cation channel activity 18.7500 8 yes
GO:0005244 voltage-gated ion channel activity 18.7500 4 yes
GO:0005248 voltage-gated sodium channel activity 18.7500 7 yes
GO:0005249 voltage-gated potassium channel activity 18.7500 6 yes
GO:0005267 potassium channel activity 18.7500 6 yes
GO:0005272 sodium channel activity 18.7500 6 yes
GO:0015079 potassium ion transmembrane transporter activity 18.7500 6 yes
GO:0022832 voltage-gated channel activity 18.7500 6 yes
GO:0022843 voltage-gated cation channel activity 18.7500 5 yes
GO:0030551 cyclic nucleotide binding 18.7500 4 yes
GO:0030552 cAMP binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HCN2_HUMAN
GO:0051049 regulation of transport 62.5000 4 yes
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0010243 response to organonitrogen compound 56.2500 4 yes
GO:0071310 cellular response to organic substance 56.2500 4 yes
GO:0071417 cellular response to organonitrogen compound 56.2500 4 yes
GO:1901699 cellular response to nitrogen compound 56.2500 4 yes
GO:1901701 cellular response to oxygen-containing compound 56.2500 4 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0043269 regulation of ion transport 50.0000 5 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 43.7500 4 no
GO:0006811 ion transport 43.7500 4 yes
GO:0006812 cation transport 43.7500 5 yes
GO:0014070 response to organic cyclic compound 43.7500 4 yes
GO:0030001 metal ion transport 43.7500 6 yes
GO:0034762 regulation of transmembrane transport 43.7500 4 yes
GO:0034765 regulation of ion transmembrane transport 43.7500 5 yes
GO:0071407 cellular response to organic cyclic compound 43.7500 5 yes
GO:0008104 protein localization 43.7500 4 no
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0009966 regulation of signal transduction 43.7500 4 no
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0051130 positive regulation of cellular component organization 43.7500 5 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010647 positive regulation of cell communication 37.5000 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0050890 cognition 37.5000 4 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 37.5000 4 no
GO:0060548 negative regulation of cell death 31.2500 5 no
GO:0014074 response to purine-containing compound 31.2500 5 yes
GO:0046683 response to organophosphorus 31.2500 4 yes
GO:0030030 cell projection organization 31.2500 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.2500 5 no
GO:0006996 organelle organization 31.2500 4 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0010648 negative regulation of cell communication 31.2500 5 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0010975 regulation of neuron projection development 31.2500 7 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 no
GO:0023057 negative regulation of signaling 31.2500 4 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0036211 protein modification process 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0051094 positive regulation of developmental process 31.2500 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.2500 5 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 25.0000 8 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0007613 memory 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0003254 regulation of membrane depolarization 25.0000 4 yes
GO:0006814 sodium ion transport 25.0000 7 yes
GO:0035725 sodium ion transmembrane transport 25.0000 6 yes
GO:0098655 cation transmembrane transport 25.0000 4 yes
GO:0098657 import into cell 25.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 25.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 25.0000 5 yes
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010942 positive regulation of cell death 25.0000 5 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050778 positive regulation of immune response 25.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0006813 potassium ion transport 18.7500 7 yes
GO:0051591 response to cAMP 18.7500 4 yes
GO:0051899 membrane depolarization 18.7500 4 yes
GO:0070305 response to cGMP 18.7500 4 yes
GO:0071320 cellular response to cAMP 18.7500 5 yes
GO:0071321 cellular response to cGMP 18.7500 5 yes
GO:0071805 potassium ion transmembrane transport 18.7500 6 yes
GO:0086010 membrane depolarization during action potential 12.5000 5 yes
GO:0086012 membrane depolarization during cardiac muscle cell action potential 12.5000 6 yes
GO:0098659 inorganic cation import across plasma membrane 12.5000 5 yes
GO:0098719 sodium ion import across plasma membrane 12.5000 6 yes
GO:0099587 inorganic ion import across plasma membrane 12.5000 4 yes
GO:1990573 potassium ion import across plasma membrane 12.5000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in HCN2_HUMAN
DOID:331 central nervous system disease 18.7500 3 yes
DOID:936 brain disease 18.7500 4 yes
DOID:0111297 familial febrile seizures 12.5000 5 yes
DOID:0111310 familial febrile seizures 2 12.5000 6 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
HCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] Low throughput yes yes
HCN2_HUMAN [view entry] [view interactions] Low throughput yes no
KCNE2_HUMAN [view interactions] Low throughput no no
HCN4_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
HCN3_HUMAN [view interactions] Computational no yes
CRTC1_HUMAN [view entry] [view interactions] Computational yes yes