Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HCN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
126 Ser Leu Febrileseizures,familial,2(FEB2) -
246 Val Met Epilepsy,idiopathicgeneralized17(EIG17) -
515 Glu Lys Epilepsy,idiopathicgeneralized17(EIG17) -
632 Ser Trp Epilepsy,idiopathicgeneralized17(EIG17) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HCN2_HUMAN
GO:0000166 nucleotide binding 53.3333 4 yes
GO:0017076 purine nucleotide binding 53.3333 5 yes
GO:0032555 purine ribonucleotide binding 53.3333 4 yes
GO:0043168 anion binding 53.3333 4 yes
GO:0030554 adenyl nucleotide binding 46.6667 6 yes
GO:0032559 adenyl ribonucleotide binding 46.6667 5 yes
GO:0005216 monoatomic ion channel activity 40.0000 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 40.0000 4 yes
GO:0015267 channel activity 40.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 40.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 40.0000 5 yes
GO:0043169 cation binding 40.0000 4 no
GO:0046872 metal ion binding 40.0000 5 no
GO:0005261 monoatomic cation channel activity 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0015081 sodium ion transmembrane transporter activity 26.6667 6 yes
GO:0015276 ligand-gated monoatomic ion channel activity 26.6667 5 yes
GO:0022834 ligand-gated channel activity 26.6667 6 yes
GO:0022836 gated channel activity 26.6667 5 yes
GO:0005524 ATP binding 26.6667 5 no
GO:0046875 ephrin receptor binding 26.6667 4 no
GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 20.0000 6 yes
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 20.0000 7 yes
GO:0005222 intracellularly cAMP-activated cation channel activity 20.0000 8 yes
GO:0005244 voltage-gated monoatomic ion channel activity 20.0000 5 yes
GO:0005248 voltage-gated sodium channel activity 20.0000 7 yes
GO:0005249 voltage-gated potassium channel activity 20.0000 7 yes
GO:0005267 potassium channel activity 20.0000 6 yes
GO:0005272 sodium channel activity 20.0000 6 yes
GO:0015079 potassium ion transmembrane transporter activity 20.0000 6 yes
GO:0022832 voltage-gated channel activity 20.0000 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 20.0000 6 yes
GO:0030551 cyclic nucleotide binding 20.0000 5 yes
GO:0030552 cAMP binding 20.0000 5 yes
GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 20.0000 6 yes
GO:0099094 ligand-gated monoatomic cation channel activity 20.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HCN2_HUMAN
GO:0010243 response to organonitrogen compound 60.0000 4 yes
GO:0071310 cellular response to organic substance 60.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 60.0000 4 yes
GO:1901699 cellular response to nitrogen compound 60.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 60.0000 4 yes
GO:0010646 regulation of cell communication 53.3333 4 no
GO:0048522 positive regulation of cellular process 46.6667 4 no
GO:0048523 negative regulation of cellular process 46.6667 4 no
GO:0006811 monoatomic ion transport 46.6667 4 yes
GO:0006812 monoatomic cation transport 46.6667 5 yes
GO:0014070 response to organic cyclic compound 46.6667 4 yes
GO:0030001 metal ion transport 46.6667 6 yes
GO:0071407 cellular response to organic cyclic compound 46.6667 5 yes
GO:0008104 protein localization 46.6667 4 no
GO:0009966 regulation of signal transduction 46.6667 4 no
GO:0022607 cellular component assembly 46.6667 4 no
GO:0031323 regulation of cellular metabolic process 46.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0050890 cognition 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0098657 import into cell 40.0000 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0050778 positive regulation of immune response 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0014074 response to purine-containing compound 33.3333 5 yes
GO:0046683 response to organophosphorus 33.3333 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 33.3333 4 no
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031328 positive regulation of cellular biosynthetic process 26.6667 6 no
GO:0031401 positive regulation of protein modification process 26.6667 7 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 no
GO:0048585 negative regulation of response to stimulus 26.6667 4 no
GO:0050807 regulation of synapse organization 26.6667 5 no
GO:0050851 antigen receptor-mediated signaling pathway 26.6667 5 no
GO:0051094 positive regulation of developmental process 26.6667 4 no
GO:0051129 negative regulation of cellular component organization 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0051248 negative regulation of protein metabolic process 26.6667 6 no
GO:0071702 organic substance transport 26.6667 4 no
GO:0071705 nitrogen compound transport 26.6667 4 no
GO:1902903 regulation of supramolecular fiber organization 26.6667 5 no
GO:0051336 regulation of hydrolase activity 26.6667 4 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:0010647 positive regulation of cell communication 26.6667 5 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0043269 regulation of monoatomic ion transport 26.6667 5 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0141124 intracellular signaling cassette 26.6667 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 26.6667 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 26.6667 5 no
GO:0003254 regulation of membrane depolarization 26.6667 4 yes
GO:0006814 sodium ion transport 26.6667 7 yes
GO:0035725 sodium ion transmembrane transport 26.6667 5 yes
GO:0051899 membrane depolarization 26.6667 4 yes
GO:0098655 monoatomic cation transmembrane transport 26.6667 4 yes
GO:0098662 inorganic cation transmembrane transport 26.6667 4 yes
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0009891 positive regulation of biosynthetic process 26.6667 5 no
GO:0009892 negative regulation of metabolic process 26.6667 4 no
GO:0009968 negative regulation of signal transduction 26.6667 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0010628 positive regulation of gene expression 26.6667 7 no
GO:0010975 regulation of neuron projection development 26.6667 7 no
GO:0031324 negative regulation of cellular metabolic process 26.6667 5 no
GO:0006813 potassium ion transport 20.0000 7 yes
GO:0051591 response to cAMP 20.0000 4 yes
GO:0070305 response to cGMP 20.0000 4 yes
GO:0071320 cellular response to cAMP 20.0000 5 yes
GO:0071321 cellular response to cGMP 20.0000 5 yes
GO:0071805 potassium ion transmembrane transport 20.0000 5 yes
GO:0086010 membrane depolarization during action potential 13.3333 5 yes
GO:0086012 membrane depolarization during cardiac muscle cell action potential 13.3333 6 yes
GO:0098659 inorganic cation import across plasma membrane 13.3333 5 yes
GO:0098719 sodium ion import across plasma membrane 13.3333 6 yes
GO:0099587 inorganic ion import across plasma membrane 13.3333 4 yes
GO:1990573 potassium ion import across plasma membrane 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
HCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] Low throughput yes yes
HCN2_HUMAN [view entry] [view interactions] Low throughput yes no
KCNE2_HUMAN [view interactions] Low throughput no no
HCN4_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
BICD1_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes