BLVRB_HUMAN
Evidence for PS localization
Functions
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BLVRB_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0004074 | biliverdin reductase (NAD(P)H) activity | 10.0000 | 5 | yes |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 10.0000 | 4 | yes |
| GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | 10.0000 | 4 | yes |
| GO:0042602 | riboflavin reductase (NADPH) activity | 10.0000 | 5 | yes |
| GO:0106276 | biliberdin reductase NAD+ activity | 10.0000 | 6 | yes |
| GO:0106277 | biliverdin reductase (NADPH) activity | 10.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BLVRB_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 45.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 35.0000 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 30.0000 | 4 | yes |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0006778 | porphyrin-containing compound metabolic process | 10.0000 | 5 | yes |
| GO:0006787 | porphyrin-containing compound catabolic process | 10.0000 | 6 | yes |
| GO:0033013 | tetrapyrrole metabolic process | 10.0000 | 4 | yes |
| GO:0033015 | tetrapyrrole catabolic process | 10.0000 | 5 | yes |
| GO:0042167 | heme catabolic process | 10.0000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 10.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BLVRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A1AG1_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANX10_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |