BLVRB_HUMAN
Evidence for PS localization
Functions
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BLVRB_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0004074 | biliverdin reductase (NAD(P)+) activity | 12.5000 | 5 | yes |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 12.5000 | 4 | yes |
| GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | 12.5000 | 4 | yes |
| GO:0042602 | riboflavin reductase (NADPH) activity | 12.5000 | 5 | yes |
| GO:0106276 | biliberdin reductase NAD+ activity | 12.5000 | 6 | yes |
| GO:0106277 | biliverdin reductase (NADP+) activity | 12.5000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BLVRB_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 25.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0006778 | porphyrin-containing compound metabolic process | 12.5000 | 5 | yes |
| GO:0006787 | porphyrin-containing compound catabolic process | 12.5000 | 6 | yes |
| GO:0019439 | aromatic compound catabolic process | 12.5000 | 4 | yes |
| GO:0033013 | tetrapyrrole metabolic process | 12.5000 | 4 | yes |
| GO:0033015 | tetrapyrrole catabolic process | 12.5000 | 5 | yes |
| GO:0042167 | heme catabolic process | 12.5000 | 4 | yes |
| GO:0044270 | cellular nitrogen compound catabolic process | 12.5000 | 4 | yes |
| GO:0046700 | heterocycle catabolic process | 12.5000 | 4 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 12.5000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BLVRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STYX_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANX10_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| A1AG1_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| RIFK_HUMAN | [view interactions] | Computational | no | yes |
| PPAL_HUMAN | [view interactions] | Computational | no | no |
| BIEA_HUMAN | [view interactions] | Computational | no | yes |
| HMOX1_HUMAN | [view interactions] | Computational | no | no |