NSG1_HUMAN
Evidence for PS localization
Functions
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse . Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome . In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NSG1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 30.7692 | 4 | no |
| GO:0015267 | channel activity | 30.7692 | 4 | no |
| GO:0022836 | gated channel activity | 30.7692 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.7692 | 4 | no |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 23.0769 | 5 | no |
| GO:0005261 | monoatomic cation channel activity | 23.0769 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 23.0769 | 4 | no |
| GO:0022832 | voltage-gated channel activity | 23.0769 | 6 | no |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 23.0769 | 6 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 23.0769 | 5 | no |
| GO:0003723 | RNA binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NSG1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 30.7692 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | yes |
| GO:0010646 | regulation of cell communication | 30.7692 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | yes |
| GO:0036211 | protein modification process | 30.7692 | 4 | no |
| GO:0043412 | macromolecule modification | 30.7692 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 30.7692 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.0769 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | yes |
| GO:0015031 | protein transport | 23.0769 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 23.0769 | 4 | yes |
| GO:0032456 | endocytic recycling | 23.0769 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 23.0769 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | yes |
| GO:0071702 | organic substance transport | 23.0769 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 23.0769 | 4 | no |
| GO:0006812 | monoatomic cation transport | 23.0769 | 5 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 23.0769 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 23.0769 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 15.3846 | 7 | yes |
| GO:0035418 | protein localization to synapse | 15.3846 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 15.3846 | 5 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 15.3846 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 15.3846 | 7 | yes |
| GO:0072657 | protein localization to membrane | 15.3846 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 15.3846 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 15.3846 | 4 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 15.3846 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 15.3846 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 15.3846 | 6 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 15.3846 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 15.3846 | 4 | yes |
| GO:0099536 | synaptic signaling | 15.3846 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 15.3846 | 5 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 15.3846 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 15.3846 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 15.3846 | 5 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 15.3846 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 15.3846 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 15.3846 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KASH5_HUMAN | [view interactions] | High throughput | no | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| TM139_HUMAN | [view interactions] | High throughput | no | no |
| FNDC9_HUMAN | [view interactions] | High throughput | no | no |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TM207_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI2L3_HUMAN | [view interactions] | High throughput | no | no |
| PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR42_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| GPA33_HUMAN | [view interactions] | High throughput | no | no |
| FIMP_HUMAN | [view interactions] | High throughput | no | no |
| PLPP2_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| S23A2_HUMAN | [view interactions] | High throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| EVI2B_HUMAN | [view interactions] | High throughput | no | no |
| KI2S2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DB129_HUMAN | [view interactions] | High throughput | no | no |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |