NSG1_HUMAN
Evidence for PS localization
Functions
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse . Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome . In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NSG1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 27.2727 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NSG1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | yes |
| GO:0036211 | protein modification process | 36.3636 | 4 | no |
| GO:0043412 | macromolecule modification | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | yes |
| GO:0071702 | organic substance transport | 27.2727 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.2727 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 27.2727 | 5 | no |
| GO:0006886 | intracellular protein transport | 27.2727 | 4 | yes |
| GO:0008104 | protein localization | 27.2727 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | yes |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | yes |
| GO:0015031 | protein transport | 27.2727 | 4 | yes |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 27.2727 | 4 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 18.1818 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 18.1818 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 18.1818 | 5 | yes |
| GO:0072657 | protein localization to membrane | 18.1818 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 18.1818 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 18.1818 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 18.1818 | 4 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 18.1818 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 18.1818 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 18.1818 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 18.1818 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 18.1818 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 18.1818 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 18.1818 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 18.1818 | 5 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 18.1818 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 18.1818 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 18.1818 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 18.1818 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 18.1818 | 4 | yes |
| GO:0016197 | endosomal transport | 18.1818 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 18.1818 | 5 | yes |
| GO:0032456 | endocytic recycling | 18.1818 | 5 | yes |
| GO:0035418 | protein localization to synapse | 18.1818 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KASH5_HUMAN | [view interactions] | High throughput | no | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| TM139_HUMAN | [view interactions] | High throughput | no | no |
| FNDC9_HUMAN | [view interactions] | High throughput | no | no |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TM207_HUMAN | [view interactions] | High throughput | no | no |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI2L3_HUMAN | [view interactions] | High throughput | no | no |
| PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR42_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| GPA33_HUMAN | [view interactions] | High throughput | no | no |
| FIMP_HUMAN | [view interactions] | High throughput | no | no |
| PLPP2_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| S23A2_HUMAN | [view interactions] | High throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| EVI2B_HUMAN | [view interactions] | High throughput | no | no |
| KI2S2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DB129_HUMAN | [view interactions] | High throughput | no | no |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |