Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ZDHC8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ZDHC8_HUMAN
GO:0043168 anion binding 75.0000 4 no
GO:0000166 nucleotide binding 68.7500 4 no
GO:0017076 purine nucleotide binding 68.7500 5 no
GO:0032555 purine ribonucleotide binding 68.7500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 68.7500 4 no
GO:0003924 GTPase activity 62.5000 7 no
GO:0005525 GTP binding 62.5000 5 no
GO:0016462 pyrophosphatase activity 62.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 62.5000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 62.5000 6 no
GO:0019001 guanyl nucleotide binding 62.5000 6 no
GO:0032561 guanyl ribonucleotide binding 62.5000 5 no
GO:0019900 kinase binding 43.7500 4 no
GO:0019901 protein kinase binding 37.5000 5 no
GO:0019003 GDP binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ZDHC8_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0051128 regulation of cellular component organization 75.0000 4 no
GO:0022607 cellular component assembly 62.5000 4 yes
GO:0051049 regulation of transport 56.2500 4 yes
GO:0030334 regulation of cell migration 56.2500 5 no
GO:0031344 regulation of cell projection organization 56.2500 5 no
GO:0048523 negative regulation of cellular process 56.2500 4 no
GO:2000145 regulation of cell motility 56.2500 4 no
GO:0006996 organelle organization 56.2500 4 no
GO:0007264 small GTPase-mediated signal transduction 56.2500 5 no
GO:0141124 intracellular signaling cassette 56.2500 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0007010 cytoskeleton organization 50.0000 5 no
GO:0008284 positive regulation of cell population proliferation 43.7500 5 no
GO:0009967 positive regulation of signal transduction 43.7500 5 no
GO:0010647 positive regulation of cell communication 43.7500 5 no
GO:0023056 positive regulation of signaling 43.7500 4 no
GO:0030030 cell projection organization 43.7500 4 no
GO:0030335 positive regulation of cell migration 43.7500 6 no
GO:0031325 positive regulation of cellular metabolic process 43.7500 5 no
GO:0031346 positive regulation of cell projection organization 43.7500 6 no
GO:0040017 positive regulation of locomotion 43.7500 4 no
GO:0051094 positive regulation of developmental process 43.7500 4 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 43.7500 6 no
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:2000147 positive regulation of cell motility 43.7500 5 no
GO:0007015 actin filament organization 43.7500 5 no
GO:0022603 regulation of anatomical structure morphogenesis 43.7500 4 no
GO:0032970 regulation of actin filament-based process 43.7500 4 no
GO:0097435 supramolecular fiber organization 43.7500 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0030155 regulation of cell adhesion 37.5000 4 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 no
GO:0032956 regulation of actin cytoskeleton organization 37.5000 5 no
GO:0033043 regulation of organelle organization 37.5000 5 no
GO:0051493 regulation of cytoskeleton organization 37.5000 6 no
GO:0008104 protein localization 37.5000 4 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0032880 regulation of protein localization 31.2500 5 yes
GO:0060341 regulation of cellular localization 31.2500 4 yes
GO:1903829 positive regulation of protein localization 31.2500 5 yes
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0001934 positive regulation of protein phosphorylation 31.2500 8 no
GO:0002685 regulation of leukocyte migration 31.2500 4 no
GO:0010562 positive regulation of phosphorus metabolic process 31.2500 6 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0031175 neuron projection development 31.2500 6 no
GO:0031399 regulation of protein modification process 31.2500 6 no
GO:0031401 positive regulation of protein modification process 31.2500 7 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0042327 positive regulation of phosphorylation 31.2500 8 no
GO:0042981 regulation of apoptotic process 31.2500 5 no
GO:0043067 regulation of programmed cell death 31.2500 4 no
GO:0045595 regulation of cell differentiation 31.2500 4 no
GO:0045785 positive regulation of cell adhesion 31.2500 5 no
GO:0045937 positive regulation of phosphate metabolic process 31.2500 7 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0051240 positive regulation of multicellular organismal process 31.2500 4 no
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:2000026 regulation of multicellular organismal development 31.2500 4 no
GO:0010810 regulation of cell-substrate adhesion 31.2500 5 no
GO:0022604 regulation of cell morphogenesis 31.2500 5 no
GO:0030031 cell projection assembly 31.2500 5 no
GO:0044089 positive regulation of cellular component biogenesis 31.2500 5 no
GO:0060491 regulation of cell projection assembly 31.2500 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 31.2500 6 no
GO:0043933 protein-containing complex organization 25.0000 4 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:0001894 tissue homeostasis 25.0000 4 no
GO:0010324 membrane invagination 25.0000 5 no
GO:0016055 Wnt signaling pathway 25.0000 4 no
GO:0016601 Rac protein signal transduction 25.0000 6 no
GO:0030865 cortical cytoskeleton organization 25.0000 6 no
GO:0061024 membrane organization 25.0000 4 no
GO:0099024 plasma membrane invagination 25.0000 6 no
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0010632 regulation of epithelial cell migration 25.0000 4 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 no
GO:0110053 regulation of actin filament organization 25.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:0002009 morphogenesis of an epithelium 25.0000 4 no
GO:0007266 Rho protein signal transduction 25.0000 6 no
GO:0030336 negative regulation of cell migration 25.0000 6 no
GO:0040013 negative regulation of locomotion 25.0000 4 no
GO:2000146 negative regulation of cell motility 25.0000 5 no
GO:1903076 regulation of protein localization to plasma membrane 18.7500 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 18.7500 7 yes
GO:1904375 regulation of protein localization to cell periphery 18.7500 6 yes
GO:1904377 positive regulation of protein localization to cell periphery 18.7500 6 yes
GO:1905475 regulation of protein localization to membrane 18.7500 6 yes
GO:1905477 positive regulation of protein localization to membrane 18.7500 6 yes
GO:0018193 peptidyl-amino acid modification 12.5000 5 yes
GO:0036211 protein modification process 12.5000 4 yes
GO:0043412 macromolecule modification 12.5000 4 yes
GO:0044788 modulation by host of viral process 12.5000 5 yes
GO:0051851 modulation by host of symbiont process 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
PARD3_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
CLDN1_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no