RAB15_HUMAN
Evidence for PS localization
Functions
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB15_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 4 | no |
| GO:0097718 | disordered domain specific binding | 33.3333 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | no |
| GO:0008179 | adenylate cyclase binding | 25.0000 | 4 | no |
| GO:0010856 | adenylate cyclase activator activity | 25.0000 | 4 | no |
| GO:0019209 | kinase activator activity | 25.0000 | 4 | no |
| GO:0019211 | phosphatase activator activity | 25.0000 | 4 | no |
| GO:0019887 | protein kinase regulator activity | 25.0000 | 4 | no |
| GO:0019888 | protein phosphatase regulator activity | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0030295 | protein kinase activator activity | 25.0000 | 5 | no |
| GO:0031432 | titin binding | 25.0000 | 4 | no |
| GO:0031997 | N-terminal myristoylation domain binding | 25.0000 | 4 | no |
| GO:0043539 | protein serine/threonine kinase activator activity | 25.0000 | 6 | no |
| GO:0072542 | protein phosphatase activator activity | 25.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 16.6667 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.6667 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.6667 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB15_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 41.6667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 41.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 41.6667 | 6 | no |
| GO:1904062 | regulation of cation transmembrane transport | 33.3333 | 6 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 33.3333 | 7 | no |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 33.3333 | 7 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0072657 | protein localization to membrane | 33.3333 | 4 | yes |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 33.3333 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 33.3333 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 33.3333 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 33.3333 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:0032411 | positive regulation of transporter activity | 33.3333 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 33.3333 | 5 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 33.3333 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 33.3333 | 4 | no |
| GO:0034764 | positive regulation of transmembrane transport | 33.3333 | 5 | no |
| GO:0034765 | regulation of ion transmembrane transport | 33.3333 | 5 | no |
| GO:0034767 | positive regulation of ion transmembrane transport | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 33.3333 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0043269 | regulation of ion transport | 33.3333 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 33.3333 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 33.3333 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 33.3333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 33.3333 | 7 | no |
| GO:0051928 | positive regulation of calcium ion transport | 33.3333 | 6 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 33.3333 | 6 | no |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 33.3333 | 6 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 33.3333 | 7 | no |
| GO:1903522 | regulation of blood circulation | 25.0000 | 5 | no |
| GO:1904063 | negative regulation of cation transmembrane transport | 25.0000 | 7 | no |
| GO:1905912 | regulation of calcium ion export across plasma membrane | 25.0000 | 8 | no |
| GO:1905913 | negative regulation of calcium ion export across plasma membrane | 25.0000 | 8 | no |
| GO:2001257 | regulation of cation channel activity | 25.0000 | 6 | no |
| GO:2001258 | negative regulation of cation channel activity | 25.0000 | 6 | no |
| GO:2001259 | positive regulation of cation channel activity | 25.0000 | 6 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | yes |
| GO:0015031 | protein transport | 25.0000 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | no |
| GO:0090150 | establishment of protein localization to membrane | 25.0000 | 4 | no |
| GO:0000086 | G2/M transition of mitotic cell cycle | 25.0000 | 5 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0005513 | detection of calcium ion | 25.0000 | 4 | no |
| GO:0006937 | regulation of muscle contraction | 25.0000 | 6 | no |
| GO:0006942 | regulation of striated muscle contraction | 25.0000 | 7 | no |
| GO:0008016 | regulation of heart contraction | 25.0000 | 6 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0010649 | regulation of cell communication by electrical coupling | 25.0000 | 5 | no |
| GO:0010799 | regulation of peptidyl-threonine phosphorylation | 25.0000 | 8 | no |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 25.0000 | 9 | no |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 25.0000 | 9 | no |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 25.0000 | 6 | no |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 25.0000 | 7 | no |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 25.0000 | 6 | no |
| GO:0010921 | regulation of phosphatase activity | 25.0000 | 5 | no |
| GO:0010922 | positive regulation of phosphatase activity | 25.0000 | 6 | no |
| GO:0019722 | calcium-mediated signaling | 25.0000 | 5 | no |
| GO:0019932 | second-messenger-mediated signaling | 25.0000 | 4 | no |
| GO:0021762 | substantia nigra development | 25.0000 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0031952 | regulation of protein autophosphorylation | 25.0000 | 8 | no |
| GO:0031954 | positive regulation of protein autophosphorylation | 25.0000 | 9 | no |
| GO:0032410 | negative regulation of transporter activity | 25.0000 | 4 | no |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0032465 | regulation of cytokinesis | 25.0000 | 5 | no |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 25.0000 | 7 | no |
| GO:0033674 | positive regulation of kinase activity | 25.0000 | 6 | no |
| GO:0034763 | negative regulation of transmembrane transport | 25.0000 | 5 | no |
| GO:0034766 | negative regulation of ion transmembrane transport | 25.0000 | 6 | no |
| GO:0035303 | regulation of dephosphorylation | 25.0000 | 7 | no |
| GO:0035304 | regulation of protein dephosphorylation | 25.0000 | 7 | no |
| GO:0035306 | positive regulation of dephosphorylation | 25.0000 | 8 | no |
| GO:0035307 | positive regulation of protein dephosphorylation | 25.0000 | 8 | no |
| GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043271 | negative regulation of ion transport | 25.0000 | 5 | no |
| GO:0043388 | positive regulation of DNA binding | 25.0000 | 5 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | 25.0000 | 6 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0044772 | mitotic cell cycle phase transition | 25.0000 | 4 | no |
| GO:0044839 | cell cycle G2/M phase transition | 25.0000 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | no |
| GO:0045860 | positive regulation of protein kinase activity | 25.0000 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0050848 | regulation of calcium-mediated signaling | 25.0000 | 6 | no |
| GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
| GO:0051099 | positive regulation of binding | 25.0000 | 4 | no |
| GO:0051101 | regulation of DNA binding | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 25.0000 | 5 | no |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 25.0000 | 6 | no |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 25.0000 | 6 | no |
| GO:0051282 | regulation of sequestering of calcium ion | 25.0000 | 4 | no |
| GO:0051284 | positive regulation of sequestering of calcium ion | 25.0000 | 5 | no |
| GO:0051302 | regulation of cell division | 25.0000 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity | 25.0000 | 5 | no |
| GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 25.0000 | 6 | no |
| GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | no |
| GO:0051592 | response to calcium ion | 25.0000 | 5 | no |
| GO:0051926 | negative regulation of calcium ion transport | 25.0000 | 6 | no |
| GO:0055117 | regulation of cardiac muscle contraction | 25.0000 | 7 | no |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 25.0000 | 6 | no |
| GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 25.0000 | 7 | no |
| GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 25.0000 | 7 | no |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 25.0000 | 7 | no |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 25.0000 | 8 | no |
| GO:0090257 | regulation of muscle system process | 25.0000 | 5 | no |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 25.0000 | 6 | no |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 25.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 25.0000 | 7 | no |
| GO:0017157 | regulation of exocytosis | 16.6667 | 5 | yes |
| GO:0032870 | cellular response to hormone stimulus | 16.6667 | 4 | yes |
| GO:0051046 | regulation of secretion | 16.6667 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.6667 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 16.6667 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 16.6667 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 16.6667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RAB15_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 16.6667 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 16.6667 | 5 | no |
| DOID:114 | heart disease | 16.6667 | 3 | no |
| DOID:2843 | long QT syndrome | 16.6667 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MSS4_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| H2AB1_HUMAN | [view interactions] | High throughput | no | no |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| OBI1_HUMAN | [view interactions] | High throughput | no | yes |
| SEN15_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| REP15_HUMAN | [view interactions] | Computational | no | no |