Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRTC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CRTC1_HUMAN
GO:0003723 RNA binding 35.7143 4 no
GO:0140297 DNA-binding transcription factor binding 28.5714 4 yes
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0030554 adenyl nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0004674 protein serine/threonine kinase activity 21.4286 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.4286 4 no
GO:0005524 ATP binding 21.4286 5 no
GO:0016301 kinase activity 21.4286 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0106310 protein serine kinase activity 21.4286 4 no
GO:0019903 protein phosphatase binding 21.4286 5 no
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0045296 cadherin binding 21.4286 4 no
GO:0045309 protein phosphorylated amino acid binding 21.4286 4 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no
GO:0008140 cAMP response element binding protein binding 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CRTC1_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 92.8571 4 yes
GO:0060255 regulation of macromolecule metabolic process 92.8571 4 yes
GO:0080090 regulation of primary metabolic process 92.8571 4 yes
GO:0031323 regulation of cellular metabolic process 92.8571 4 yes
GO:0010468 regulation of gene expression 64.2857 5 yes
GO:0010646 regulation of cell communication 64.2857 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 64.2857 5 yes
GO:0051252 regulation of RNA metabolic process 57.1429 5 yes
GO:0009889 regulation of biosynthetic process 57.1429 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 57.1429 5 yes
GO:0031326 regulation of cellular biosynthetic process 57.1429 5 yes
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 50.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 yes
GO:0006886 intracellular protein transport 50.0000 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0015031 protein transport 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0071702 organic substance transport 50.0000 4 no
GO:0071705 nitrogen compound transport 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0006355 regulation of DNA-templated transcription 50.0000 6 yes
GO:0051128 regulation of cellular component organization 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 yes
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 yes
GO:0051049 regulation of transport 35.7143 4 no
GO:0036211 protein modification process 35.7143 4 no
GO:0043412 macromolecule modification 35.7143 4 no
GO:0006605 protein targeting 35.7143 5 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0009891 positive regulation of biosynthetic process 35.7143 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 35.7143 6 yes
GO:0010647 positive regulation of cell communication 35.7143 5 yes
GO:0023056 positive regulation of signaling 35.7143 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 35.7143 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 35.7143 6 yes
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 28.5714 8 yes
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0016310 phosphorylation 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 7 yes
GO:0022607 cellular component assembly 28.5714 4 yes
GO:0045893 positive regulation of DNA-templated transcription 28.5714 7 yes
GO:0050806 positive regulation of synaptic transmission 21.4286 5 yes
GO:0050890 cognition 21.4286 4 yes
GO:0051130 positive regulation of cellular component organization 21.4286 5 yes
GO:0065003 protein-containing complex assembly 21.4286 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 yes
GO:0021762 substantia nigra development 21.4286 4 no
GO:0034762 regulation of transmembrane transport 21.4286 4 no
GO:0034765 regulation of ion transmembrane transport 21.4286 5 no
GO:0043269 regulation of ion transport 21.4286 5 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0010628 positive regulation of gene expression 21.4286 6 no
GO:0018105 peptidyl-serine phosphorylation 21.4286 6 no
GO:0018193 peptidyl-amino acid modification 21.4286 5 no
GO:0018209 peptidyl-serine modification 21.4286 6 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0032386 regulation of intracellular transport 21.4286 5 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0000165 MAPK cascade 21.4286 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 yes
GO:0031344 regulation of cell projection organization 21.4286 5 yes
GO:0043933 protein-containing complex organization 21.4286 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 21.4286 8 yes
GO:0050773 regulation of dendrite development 21.4286 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 14.2857 4 yes
GO:0051094 positive regulation of developmental process 14.2857 4 yes
GO:0051259 protein complex oligomerization 14.2857 6 yes
GO:0051260 protein homooligomerization 14.2857 7 yes
GO:0051262 protein tetramerization 14.2857 7 yes
GO:0051289 protein homotetramerization 14.2857 8 yes
GO:0099527 postsynapse to nucleus signaling pathway 14.2857 4 yes
GO:1900006 positive regulation of dendrite development 14.2857 5 yes
GO:1900271 regulation of long-term synaptic potentiation 14.2857 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 14.2857 5 yes
GO:1902631 negative regulation of membrane hyperpolarization 14.2857 4 yes
GO:0007613 memory 14.2857 4 yes
GO:0009416 response to light stimulus 14.2857 4 yes
GO:0009648 photoperiodism 14.2857 5 yes
GO:0010976 positive regulation of neuron projection development 14.2857 7 yes
GO:0031346 positive regulation of cell projection organization 14.2857 6 yes
GO:0032793 positive regulation of CREB transcription factor activity 14.2857 5 yes
GO:0043153 entrainment of circadian clock by photoperiod 14.2857 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in CRTC1_HUMAN
DOID:331 central nervous system disease 14.2857 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MEIS1_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K1_HUMAN [view interactions] Low throughput no yes
CBP_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
TFG_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CRTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CREB1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
KCTD3_HUMAN [view interactions] High throughput no yes
CBY1_HUMAN [view interactions] High throughput no no
KI13B_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
SHRM2_HUMAN [view interactions] High throughput no yes
PDZ11_HUMAN [view interactions] High throughput no yes
REEP1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] Computational no yes
CRTC3_HUMAN [view interactions] Computational no no
CRTC2_HUMAN [view interactions] Computational no yes
PRGC1_HUMAN [view interactions] Computational no no
MAML2_HUMAN [view interactions] Computational no yes
HCN2_HUMAN [view entry] [view interactions] Computational yes no
FOS_HUMAN [view interactions] Computational no yes
SIK1_HUMAN [view interactions] Computational no yes
PER1_HUMAN [view interactions] Computational no no
HES1_HUMAN [view interactions] Computational no no
NOTC4_HUMAN [view interactions] Computational no no
HEYL_HUMAN [view interactions] Computational no no
KIBRA_HUMAN [view interactions] Computational no yes
MINT_HUMAN [view interactions] Computational no yes
RBPJL_HUMAN [view interactions] Computational no no
GRAB_HUMAN [view interactions] Computational no no
NCOR2_HUMAN [view interactions] Computational no yes
KAT2B_HUMAN [view interactions] Computational no yes
HEY1_HUMAN [view interactions] Computational no yes
DLGP5_HUMAN [view interactions] Computational no no
NCOR1_HUMAN [view interactions] Computational no yes
FCER2_HUMAN [view interactions] Computational no no
HES5_HUMAN [view interactions] Computational no yes
MAML3_HUMAN [view interactions] Computational no yes
NOTC3_HUMAN [view interactions] Computational no yes
KAT2A_HUMAN [view interactions] Computational no no
SUH_HUMAN [view interactions] Computational no yes
PLXD1_HUMAN [view interactions] Computational no yes
HDAC1_HUMAN [view interactions] Computational no no
PBX1_HUMAN [view interactions] Computational no yes
NOTC2_HUMAN [view interactions] Computational no yes
VGFR3_HUMAN [view interactions] Computational no yes
MAML1_HUMAN [view interactions] Computational no yes
HEY2_HUMAN [view interactions] Computational no no