Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ASTN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ASTN1_HUMAN
GO:0000166 nucleotide binding 42.8571 4 no
GO:0017076 purine nucleotide binding 42.8571 5 no
GO:0030554 adenyl nucleotide binding 42.8571 6 no
GO:0032555 purine ribonucleotide binding 42.8571 4 no
GO:0032559 adenyl ribonucleotide binding 42.8571 5 no
GO:0043168 anion binding 42.8571 4 no
GO:0005216 monoatomic ion channel activity 28.5714 4 no
GO:0005244 voltage-gated monoatomic ion channel activity 28.5714 5 no
GO:0005261 monoatomic cation channel activity 28.5714 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 28.5714 4 no
GO:0015267 channel activity 28.5714 4 no
GO:0022832 voltage-gated channel activity 28.5714 6 no
GO:0022836 gated channel activity 28.5714 5 no
GO:0022843 voltage-gated monoatomic cation channel activity 28.5714 6 no
GO:0022890 inorganic cation transmembrane transporter activity 28.5714 4 no
GO:0046873 metal ion transmembrane transporter activity 28.5714 5 no
GO:0005524 ATP binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ASTN1_HUMAN
GO:0008104 protein localization 57.1429 4 no
GO:0045595 regulation of cell differentiation 42.8571 4 no
GO:0060284 regulation of cell development 42.8571 5 no
GO:2000026 regulation of multicellular organismal development 42.8571 4 no
GO:0001764 neuron migration 28.5714 4 yes
GO:0001508 action potential 28.5714 4 no
GO:0006811 monoatomic ion transport 28.5714 4 no
GO:0006812 monoatomic cation transport 28.5714 5 no
GO:0030001 metal ion transport 28.5714 6 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 no
GO:0098662 inorganic cation transmembrane transport 28.5714 4 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0048522 positive regulation of cellular process 28.5714 4 no
GO:0050767 regulation of neurogenesis 28.5714 6 no
GO:0050770 regulation of axonogenesis 28.5714 5 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0006996 organelle organization 28.5714 4 no
GO:0010721 negative regulation of cell development 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043066 negative regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043069 negative regulation of programmed cell death 28.5714 5 no
GO:0045596 negative regulation of cell differentiation 28.5714 5 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KEAP1_HUMAN [view interactions] Low throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DSCAM_HUMAN [view interactions] High throughput no yes
GAS6_HUMAN [view interactions] High throughput no no
BRSK2_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes