Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SSPN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SSPN_HUMAN
GO:0003779 actin binding 71.4286 4 no
GO:0017166 vinculin binding 28.5714 4 no
GO:0046872 metal ion binding 28.5714 4 no
GO:0030165 PDZ domain binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SSPN_HUMAN
GO:0006936 muscle contraction 57.1429 4 yes
GO:0001952 regulation of cell-matrix adhesion 28.5714 6 no
GO:0001954 positive regulation of cell-matrix adhesion 28.5714 7 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0010810 regulation of cell-substrate adhesion 28.5714 5 no
GO:0010811 positive regulation of cell-substrate adhesion 28.5714 6 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045785 positive regulation of cell adhesion 28.5714 5 no
GO:0048522 positive regulation of cellular process 28.5714 4 no
GO:0051171 regulation of nitrogen compound metabolic process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0007517 muscle organ development 28.5714 4 no
GO:0002028 regulation of sodium ion transport 28.5714 7 no
GO:0010959 regulation of metal ion transport 28.5714 6 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0034765 regulation of ion transmembrane transport 28.5714 5 no
GO:0043269 regulation of ion transport 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:1902305 regulation of sodium ion transmembrane transport 28.5714 7 no
GO:1904062 regulation of cation transmembrane transport 28.5714 6 no

Disease

Term Name % Distance from top the of the tree Annotated in SSPN_HUMAN
DOID:0080000 muscular disease 28.5714 3 no
DOID:0110274 autosomal recessive limb-girdle muscular dystrophy 28.5714 8 no
DOID:11724 limb-girdle muscular dystrophy 28.5714 7 no
DOID:423 myopathy 28.5714 5 no
DOID:66 muscle tissue disease 28.5714 4 no
DOID:9884 muscular dystrophy 28.5714 6 no
DOID:0050700 cardiomyopathy 28.5714 4 no
DOID:0060036 intrinsic cardiomyopathy 28.5714 5 no
DOID:114 heart disease 28.5714 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SPT6H_HUMAN [view interactions] Low throughput no yes
H12_HUMAN [view interactions] High throughput no yes
SMO_HUMAN [view interactions] High throughput no yes
SGCD_HUMAN [view entry] [view interactions] High throughput yes no
SGCA_HUMAN [view interactions] Computational no yes
CAV3_HUMAN [view interactions] Computational no no
SNTB1_HUMAN [view entry] [view interactions] Computational yes yes
SGCB_HUMAN [view interactions] Computational no no
SGCE_HUMAN [view interactions] Computational no no
DAG1_HUMAN [view entry] [view interactions] Computational yes no
SNTB2_HUMAN [view entry] [view interactions] Computational yes no
SNTA1_HUMAN [view entry] [view interactions] Computational yes no
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
SGCZ_HUMAN [view interactions] Computational no no
SGCG_HUMAN [view interactions] Computational no no