SGCD_HUMAN
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
261 | Glu | Lys | Musculardystrophy,limb-girdle,autosomalrecessive6(LGMDR6) | - |
150 | Ser | Ala | Cardiomyopathy,dilated1L(CMD1L) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SGCD_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 70.0000 | 4 | no |
GO:0017166 | vinculin binding | 30.0000 | 4 | no |
GO:0046872 | metal ion binding | 30.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SGCD_HUMAN |
---|---|---|---|---|
GO:0006936 | muscle contraction | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 40.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 40.0000 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0007517 | muscle organ development | 30.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 30.0000 | 6 | no |
GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
GO:0044057 | regulation of system process | 30.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 30.0000 | 4 | no |
GO:0002028 | regulation of sodium ion transport | 30.0000 | 7 | no |
GO:0010959 | regulation of metal ion transport | 30.0000 | 6 | no |
GO:0034762 | regulation of transmembrane transport | 30.0000 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 30.0000 | 5 | no |
GO:0043269 | regulation of ion transport | 30.0000 | 5 | no |
GO:0051049 | regulation of transport | 30.0000 | 4 | no |
GO:1902305 | regulation of sodium ion transmembrane transport | 30.0000 | 7 | no |
GO:1904062 | regulation of cation transmembrane transport | 30.0000 | 6 | no |
GO:0019722 | calcium-mediated signaling | 20.0000 | 5 | yes |
GO:0019932 | second-messenger-mediated signaling | 20.0000 | 4 | yes |
GO:0055001 | muscle cell development | 20.0000 | 4 | yes |
GO:0060537 | muscle tissue development | 20.0000 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SGCD_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 40.0000 | 4 | yes |
DOID:0060036 | intrinsic cardiomyopathy | 40.0000 | 5 | yes |
DOID:0080000 | muscular disease | 40.0000 | 3 | yes |
DOID:114 | heart disease | 40.0000 | 3 | yes |
DOID:423 | myopathy | 40.0000 | 5 | yes |
DOID:66 | muscle tissue disease | 40.0000 | 4 | yes |
DOID:9884 | muscular dystrophy | 40.0000 | 6 | yes |
DOID:0110274 | autosomal recessive limb-girdle muscular dystrophy | 20.0000 | 8 | yes |
DOID:11724 | limb-girdle muscular dystrophy | 20.0000 | 7 | yes |
DOID:12930 | dilated cardiomyopathy | 20.0000 | 6 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FLNC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
SGCB_HUMAN | [view interactions] | Low throughput | no | no |
SGCA_HUMAN | [view interactions] | Low throughput | no | yes |
ADA_HUMAN | [view interactions] | High throughput | no | no |
AACT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
F241A_HUMAN | [view interactions] | High throughput | no | yes |
DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
F241B_HUMAN | [view interactions] | High throughput | no | yes |
PPAL_HUMAN | [view interactions] | High throughput | no | no |
SSPN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
CAV3_HUMAN | [view interactions] | Computational | no | no |
SNTB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SGCE_HUMAN | [view interactions] | Computational | no | no |
SNTG2_HUMAN | [view interactions] | Computational | no | no |
SNTA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
UTRN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SNTB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |