Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SGCD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
261 Glu Lys Musculardystrophy,limb-girdle,autosomalrecessive6(LGMDR6) -
150 Ser Ala Cardiomyopathy,dilated,1L(CMD1L) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SGCD_HUMAN
GO:0003779 actin binding 50.0000 4 no
GO:0017166 vinculin binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SGCD_HUMAN
GO:0006996 organelle organization 50.0000 4 no
GO:0007517 muscle organ development 33.3333 4 yes
GO:0019722 calcium-mediated signaling 33.3333 5 yes
GO:0055001 muscle cell development 33.3333 4 yes
GO:0060537 muscle tissue development 33.3333 4 yes
GO:0141124 intracellular signaling cassette 33.3333 4 yes
GO:0006936 muscle contraction 33.3333 4 no
GO:0001894 tissue homeostasis 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0007010 cytoskeleton organization 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLNC_HUMAN [view entry] [view interactions] Low throughput yes no
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
YAP1_HUMAN [view interactions] Low throughput no yes
SGCB_HUMAN [view interactions] Low throughput no no
SGCA_HUMAN [view interactions] Low throughput no yes
ADA_HUMAN [view interactions] High throughput no no
AACT_HUMAN [view entry] [view interactions] High throughput yes no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
F241A_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
CRYAA_HUMAN [view interactions] High throughput no no
SSPN_HUMAN [view entry] [view interactions] High throughput yes no
SRP09_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes