Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EFR3B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed, PubMed, PubMed). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EFR3B_HUMAN
GO:0017076 purine nucleotide binding 57.6923 4 no
GO:0032555 purine ribonucleotide binding 57.6923 4 no
GO:0035639 purine ribonucleoside triphosphate binding 57.6923 4 no
GO:0003924 GTPase activity 46.1538 7 no
GO:0005525 GTP binding 46.1538 5 no
GO:0016462 pyrophosphatase activity 46.1538 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 46.1538 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 46.1538 6 no
GO:0019001 guanyl nucleotide binding 46.1538 5 no
GO:0032561 guanyl ribonucleotide binding 46.1538 5 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0019003 GDP binding 30.7692 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in EFR3B_HUMAN
GO:0048522 positive regulation of cellular process 65.3846 4 no
GO:0008104 protein localization 57.6923 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0022607 cellular component assembly 46.1538 4 no
GO:0051049 regulation of transport 46.1538 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0071702 organic substance transport 46.1538 4 no
GO:0071705 nitrogen compound transport 46.1538 4 no
GO:0009966 regulation of signal transduction 42.3077 4 no
GO:0010646 regulation of cell communication 42.3077 4 no
GO:0048584 positive regulation of response to stimulus 42.3077 4 no
GO:0060255 regulation of macromolecule metabolic process 42.3077 4 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0010647 positive regulation of cell communication 38.4615 5 no
GO:0023056 positive regulation of signaling 38.4615 4 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 no
GO:0016192 vesicle-mediated transport 38.4615 4 no
GO:0007010 cytoskeleton organization 34.6154 5 no
GO:0007264 small GTPase mediated signal transduction 34.6154 4 no
GO:0007265 Ras protein signal transduction 34.6154 5 no
GO:0009967 positive regulation of signal transduction 34.6154 5 no
GO:0030030 cell projection organization 34.6154 4 no
GO:0030334 regulation of cell migration 34.6154 5 no
GO:0048523 negative regulation of cellular process 34.6154 4 no
GO:0071310 cellular response to organic substance 34.6154 4 no
GO:0080090 regulation of primary metabolic process 34.6154 4 no
GO:2000145 regulation of cell motility 34.6154 4 no
GO:0015031 protein transport 34.6154 4 no
GO:0010468 regulation of gene expression 30.7692 5 no
GO:0031323 regulation of cellular metabolic process 30.7692 4 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0051094 positive regulation of developmental process 30.7692 4 no
GO:0051171 regulation of nitrogen compound metabolic process 30.7692 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0060627 regulation of vesicle-mediated transport 30.7692 4 no
GO:0006796 phosphate-containing compound metabolic process 26.9231 4 yes
GO:0097435 supramolecular fiber organization 26.9231 4 no
GO:0010941 regulation of cell death 26.9231 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.9231 4 no
GO:0030155 regulation of cell adhesion 26.9231 4 no
GO:0030335 positive regulation of cell migration 26.9231 6 no
GO:0031325 positive regulation of cellular metabolic process 26.9231 5 no
GO:0031344 regulation of cell projection organization 26.9231 5 no
GO:0032970 regulation of actin filament-based process 26.9231 4 no
GO:0040017 positive regulation of locomotion 26.9231 4 no
GO:0042981 regulation of apoptotic process 26.9231 6 no
GO:0043067 regulation of programmed cell death 26.9231 5 no
GO:0045595 regulation of cell differentiation 26.9231 4 no
GO:0045785 positive regulation of cell adhesion 26.9231 5 no
GO:0051130 positive regulation of cellular component organization 26.9231 5 no
GO:0061024 membrane organization 26.9231 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.9231 6 no
GO:2000147 positive regulation of cell motility 26.9231 5 no
GO:0120036 plasma membrane bounded cell projection organization 26.9231 5 no
GO:0008284 positive regulation of cell population proliferation 26.9231 5 no
GO:0007015 actin filament organization 23.0769 5 no
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0032956 regulation of actin cytoskeleton organization 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0072657 protein localization to membrane 15.3846 4 yes
GO:0072659 protein localization to plasma membrane 15.3846 5 yes
GO:1990778 protein localization to cell periphery 15.3846 5 yes
GO:0006644 phospholipid metabolic process 11.5385 4 yes
GO:0006650 glycerophospholipid metabolic process 11.5385 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 11.5385 6 yes
GO:0008610 lipid biosynthetic process 11.5385 4 yes
GO:0008654 phospholipid biosynthetic process 11.5385 4 yes
GO:0045017 glycerolipid biosynthetic process 11.5385 4 yes
GO:0046474 glycerophospholipid biosynthetic process 11.5385 5 yes
GO:0046486 glycerolipid metabolic process 11.5385 4 yes
GO:0046488 phosphatidylinositol metabolic process 11.5385 6 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 11.5385 7 yes
GO:0090407 organophosphate biosynthetic process 11.5385 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
HXB5_HUMAN [view interactions] High throughput no no
FCAR_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
RGS20_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
ECP_HUMAN [view interactions] High throughput no no
TIGD5_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
S10A2_HUMAN [view interactions] High throughput no no
K0895_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
S10A6_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
DNJ5B_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PANX1_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
RNF43_HUMAN [view interactions] High throughput no yes
TTC7B_HUMAN [view entry] [view interactions] Computational yes yes
TTC7A_HUMAN [view interactions] Computational no yes
PI4KA_HUMAN [view entry] [view interactions] Computational yes yes