Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ASIC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ASIC2_HUMAN
GO:0005216 monoatomic ion channel activity 37.5000 4 yes
GO:0005261 monoatomic cation channel activity 37.5000 5 yes
GO:0005272 sodium channel activity 37.5000 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 37.5000 4 yes
GO:0015081 sodium ion transmembrane transporter activity 37.5000 6 yes
GO:0015267 channel activity 37.5000 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 37.5000 5 yes
GO:0015280 ligand-gated sodium channel activity 37.5000 7 yes
GO:0022834 ligand-gated channel activity 37.5000 6 yes
GO:0022836 gated channel activity 37.5000 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 37.5000 4 yes
GO:0046873 metal ion transmembrane transporter activity 37.5000 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 37.5000 6 yes
GO:0001664 G protein-coupled receptor binding 37.5000 4 no
GO:0019900 kinase binding 37.5000 4 no
GO:0005248 voltage-gated sodium channel activity 25.0000 7 yes
GO:0003779 actin binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030165 PDZ domain binding 25.0000 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ASIC2_HUMAN
GO:0051049 regulation of transport 87.5000 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0008104 protein localization 62.5000 4 yes
GO:0022607 cellular component assembly 62.5000 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0051130 positive regulation of cellular component organization 62.5000 5 yes
GO:0007268 chemical synaptic transmission 50.0000 7 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 6 yes
GO:0099536 synaptic signaling 50.0000 4 yes
GO:0099537 trans-synaptic signaling 50.0000 5 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0006811 monoatomic ion transport 37.5000 4 yes
GO:0006812 monoatomic cation transport 37.5000 5 yes
GO:0006814 sodium ion transport 37.5000 7 yes
GO:0007417 central nervous system development 37.5000 4 yes
GO:0007600 sensory perception 37.5000 4 yes
GO:0007606 sensory perception of chemical stimulus 37.5000 5 yes
GO:0010447 response to acidic pH 37.5000 4 yes
GO:0030001 metal ion transport 37.5000 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 37.5000 5 yes
GO:0035418 protein localization to synapse 37.5000 6 yes
GO:0035725 sodium ion transmembrane transport 37.5000 5 yes
GO:0042981 regulation of apoptotic process 37.5000 5 yes
GO:0043066 negative regulation of apoptotic process 37.5000 6 yes
GO:0043067 regulation of programmed cell death 37.5000 4 yes
GO:0043069 negative regulation of programmed cell death 37.5000 5 yes
GO:0043269 regulation of monoatomic ion transport 37.5000 5 yes
GO:0044057 regulation of system process 37.5000 4 yes
GO:0044087 regulation of cellular component biogenesis 37.5000 4 yes
GO:0050909 sensory perception of taste 37.5000 6 yes
GO:0050915 sensory perception of sour taste 37.5000 7 yes
GO:0071467 cellular response to pH 37.5000 4 yes
GO:0098655 monoatomic cation transmembrane transport 37.5000 4 yes
GO:0098662 inorganic cation transmembrane transport 37.5000 4 yes
GO:1902414 protein localization to cell junction 37.5000 5 yes
GO:0007612 learning 37.5000 4 no
GO:0050890 cognition 37.5000 4 no
GO:0051046 regulation of secretion 37.5000 5 no
GO:0051051 negative regulation of transport 37.5000 4 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:1903530 regulation of secretion by cell 37.5000 4 no
GO:0030100 regulation of endocytosis 37.5000 5 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0070201 regulation of establishment of protein localization 37.5000 6 no
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 25.0000 4 yes
GO:0003018 vascular process in circulatory system 25.0000 4 yes
GO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback 25.0000 5 yes
GO:0007416 synapse assembly 25.0000 6 yes
GO:0007422 peripheral nervous system development 25.0000 4 yes
GO:0007605 sensory perception of sound 25.0000 6 yes
GO:0009416 response to light stimulus 25.0000 4 yes
GO:0009583 detection of light stimulus 25.0000 4 yes
GO:0019229 regulation of vasoconstriction 25.0000 6 yes
GO:0034329 cell junction assembly 25.0000 5 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0035150 regulation of tube size 25.0000 4 yes
GO:0035296 regulation of tube diameter 25.0000 5 yes
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 yes
GO:0050807 regulation of synapse organization 25.0000 5 yes
GO:0050808 synapse organization 25.0000 5 yes
GO:0050954 sensory perception of mechanical stimulus 25.0000 5 yes
GO:0050974 detection of mechanical stimulus involved in sensory perception 25.0000 4 yes
GO:0050982 detection of mechanical stimulus 25.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0051962 positive regulation of nervous system development 25.0000 5 yes
GO:0051963 regulation of synapse assembly 25.0000 6 yes
GO:0051965 positive regulation of synapse assembly 25.0000 6 yes
GO:0071466 cellular response to xenobiotic stimulus 25.0000 4 yes
GO:0071468 cellular response to acidic pH 25.0000 5 yes
GO:0097746 blood vessel diameter maintenance 25.0000 5 yes
GO:1901888 regulation of cell junction assembly 25.0000 5 yes
GO:1901890 positive regulation of cell junction assembly 25.0000 6 yes
GO:1903522 regulation of blood circulation 25.0000 5 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:0006836 neurotransmitter transport 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0046928 regulation of neurotransmitter secretion 25.0000 5 no
GO:0046929 negative regulation of neurotransmitter secretion 25.0000 6 no
GO:0051048 negative regulation of secretion 25.0000 5 no
GO:0051588 regulation of neurotransmitter transport 25.0000 5 no
GO:0051589 negative regulation of neurotransmitter transport 25.0000 5 no
GO:1903531 negative regulation of secretion by cell 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0002791 regulation of peptide secretion 25.0000 6 no
GO:0006996 organelle organization 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010639 negative regulation of organelle organization 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0015844 monoamine transport 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044788 modulation by host of viral process 25.0000 5 no
GO:0044827 modulation by host of viral genome replication 25.0000 6 no
GO:0046883 regulation of hormone secretion 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0050708 regulation of protein secretion 25.0000 5 no
GO:0050796 regulation of insulin secretion 25.0000 6 no
GO:0050905 neuromuscular process 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0051494 negative regulation of cytoskeleton organization 25.0000 7 no
GO:0051851 modulation by host of symbiont process 25.0000 4 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0090087 regulation of peptide transport 25.0000 5 no
GO:0090276 regulation of peptide hormone secretion 25.0000 5 no
GO:0110053 regulation of actin filament organization 25.0000 6 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902904 negative regulation of supramolecular fiber organization 25.0000 6 no
GO:1903533 regulation of protein targeting 25.0000 7 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1905475 regulation of protein localization to membrane 25.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:0002090 regulation of receptor internalization 25.0000 7 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0043113 receptor clustering 25.0000 5 no
GO:0048259 regulation of receptor-mediated endocytosis 25.0000 6 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0097061 dendritic spine organization 25.0000 5 no
GO:0099173 postsynapse organization 25.0000 4 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASIC3_HUMAN [view interactions] Low throughput no no
ASIC1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
STOM_HUMAN [view entry] [view interactions] Low throughput yes yes
ASIC2_HUMAN [view entry] [view interactions] Low throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
PLD2_HUMAN [view interactions] High throughput no yes
PLD1_HUMAN [view interactions] High throughput no no
FACR2_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA2_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
ERMP1_HUMAN [view interactions] High throughput no no
YMEL1_HUMAN [view interactions] High throughput no yes
HS2ST_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes