Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GSTM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GSTM2_HUMAN
GO:0043168 anion binding 38.4615 4 yes
GO:0030165 PDZ domain binding 30.7692 4 no
GO:0015631 tubulin binding 30.7692 4 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0043169 cation binding 30.7692 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0004364 glutathione transferase activity 23.0769 4 yes
GO:0042803 protein homodimerization activity 23.0769 4 yes
GO:0003779 actin binding 23.0769 4 no
GO:0046914 transition metal ion binding 23.0769 6 no
GO:0031406 carboxylic acid binding 15.3846 4 yes
GO:0033293 monocarboxylic acid binding 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GSTM2_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 yes
GO:0048523 negative regulation of cellular process 76.9231 4 yes
GO:0051049 regulation of transport 61.5385 4 yes
GO:0006996 organelle organization 61.5385 4 no
GO:0009893 positive regulation of metabolic process 61.5385 4 no
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0051128 regulation of cellular component organization 61.5385 4 no
GO:0060255 regulation of macromolecule metabolic process 61.5385 4 no
GO:0022607 cellular component assembly 61.5385 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.8462 5 no
GO:0019220 regulation of phosphate metabolic process 53.8462 6 no
GO:0031325 positive regulation of cellular metabolic process 53.8462 5 no
GO:0051174 regulation of phosphorus metabolic process 53.8462 5 no
GO:0051246 regulation of protein metabolic process 53.8462 5 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0009889 regulation of biosynthetic process 53.8462 4 no
GO:0009892 negative regulation of metabolic process 53.8462 4 no
GO:0009966 regulation of signal transduction 53.8462 4 no
GO:0010468 regulation of gene expression 53.8462 6 no
GO:0010556 regulation of macromolecule biosynthetic process 53.8462 5 no
GO:0010646 regulation of cell communication 53.8462 4 no
GO:0031324 negative regulation of cellular metabolic process 53.8462 5 no
GO:0031326 regulation of cellular biosynthetic process 53.8462 5 no
GO:0043412 macromolecule modification 53.8462 4 no
GO:0010243 response to organonitrogen compound 46.1538 4 yes
GO:0051050 positive regulation of transport 46.1538 4 yes
GO:0051051 negative regulation of transport 46.1538 4 yes
GO:0071310 cellular response to organic substance 46.1538 4 yes
GO:0071417 cellular response to organonitrogen compound 46.1538 4 yes
GO:1901699 cellular response to nitrogen compound 46.1538 4 yes
GO:0031399 regulation of protein modification process 46.1538 6 no
GO:0042325 regulation of phosphorylation 46.1538 7 no
GO:0044087 regulation of cellular component biogenesis 46.1538 4 no
GO:0051129 negative regulation of cellular component organization 46.1538 5 no
GO:0051247 positive regulation of protein metabolic process 46.1538 6 no
GO:0009894 regulation of catabolic process 46.1538 4 no
GO:0010563 negative regulation of phosphorus metabolic process 46.1538 6 no
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 no
GO:0010648 negative regulation of cell communication 46.1538 5 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:0023057 negative regulation of signaling 46.1538 4 no
GO:0030162 regulation of proteolysis 46.1538 6 no
GO:0036211 protein modification process 46.1538 4 no
GO:0045936 negative regulation of phosphate metabolic process 46.1538 7 no
GO:0050804 modulation of chemical synaptic transmission 46.1538 5 no
GO:0099177 regulation of trans-synaptic signaling 46.1538 4 no
GO:0031327 negative regulation of cellular biosynthetic process 38.4615 6 no
GO:0031328 positive regulation of cellular biosynthetic process 38.4615 6 no
GO:0031329 regulation of cellular catabolic process 38.4615 5 no
GO:0032880 regulation of protein localization 38.4615 5 no
GO:0060341 regulation of cellular localization 38.4615 4 no
GO:0071702 organic substance transport 38.4615 4 no
GO:0071705 nitrogen compound transport 38.4615 4 no
GO:1901701 cellular response to oxygen-containing compound 38.4615 4 no
GO:1903829 positive regulation of protein localization 38.4615 5 no
GO:0034762 regulation of transmembrane transport 38.4615 4 yes
GO:0044057 regulation of system process 38.4615 4 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0031401 positive regulation of protein modification process 38.4615 7 no
GO:0009968 negative regulation of signal transduction 38.4615 5 no
GO:0010647 positive regulation of cell communication 38.4615 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.4615 5 no
GO:0022603 regulation of anatomical structure morphogenesis 38.4615 4 no
GO:0031400 negative regulation of protein modification process 38.4615 7 no
GO:0034330 cell junction organization 38.4615 4 no
GO:0042326 negative regulation of phosphorylation 38.4615 8 no
GO:0045595 regulation of cell differentiation 38.4615 4 no
GO:0045862 positive regulation of proteolysis 38.4615 7 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 no
GO:0048585 negative regulation of response to stimulus 38.4615 4 no
GO:0051248 negative regulation of protein metabolic process 38.4615 6 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 no
GO:0043933 protein-containing complex organization 38.4615 4 no
GO:0065003 protein-containing complex assembly 38.4615 5 no
GO:0009890 negative regulation of biosynthetic process 38.4615 5 no
GO:0009891 positive regulation of biosynthetic process 38.4615 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.4615 6 no
GO:0010629 negative regulation of gene expression 30.7692 7 no
GO:0042176 regulation of protein catabolic process 30.7692 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0051046 regulation of secretion 30.7692 5 no
GO:0051094 positive regulation of developmental process 30.7692 4 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0062012 regulation of small molecule metabolic process 30.7692 4 no
GO:0070201 regulation of establishment of protein localization 30.7692 6 no
GO:0006631 fatty acid metabolic process 30.7692 4 yes
GO:1902903 regulation of supramolecular fiber organization 30.7692 5 no
GO:1903530 regulation of secretion by cell 30.7692 4 no
GO:0008610 lipid biosynthetic process 30.7692 4 yes
GO:0010959 regulation of metal ion transport 30.7692 6 yes
GO:0019752 carboxylic acid metabolic process 30.7692 5 yes
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 yes
GO:0032787 monocarboxylic acid metabolic process 30.7692 6 yes
GO:0034764 positive regulation of transmembrane transport 30.7692 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 30.7692 5 yes
GO:0043269 regulation of monoatomic ion transport 30.7692 5 yes
GO:0043436 oxoacid metabolic process 30.7692 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 30.7692 5 yes
GO:0051282 regulation of sequestering of calcium ion 30.7692 4 yes
GO:0051924 regulation of calcium ion transport 30.7692 7 yes
GO:0141124 intracellular signaling cassette 30.7692 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 30.7692 7 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 30.7692 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 30.7692 6 no
GO:0042327 positive regulation of phosphorylation 30.7692 8 no
GO:0045937 positive regulation of phosphate metabolic process 30.7692 7 no
GO:0001933 negative regulation of protein phosphorylation 30.7692 8 no
GO:0006355 regulation of DNA-templated transcription 30.7692 7 no
GO:0009896 positive regulation of catabolic process 30.7692 5 no
GO:0033673 negative regulation of kinase activity 30.7692 6 no
GO:0043085 positive regulation of catalytic activity 30.7692 4 no
GO:0043086 negative regulation of catalytic activity 30.7692 4 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0050808 synapse organization 30.7692 5 no
GO:0050890 cognition 30.7692 4 no
GO:0051093 negative regulation of developmental process 30.7692 4 no
GO:0051252 regulation of RNA metabolic process 30.7692 5 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0051348 negative regulation of transferase activity 30.7692 5 no
GO:0080134 regulation of response to stress 30.7692 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 30.7692 7 no
GO:2000026 regulation of multicellular organismal development 30.7692 4 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0007005 mitochondrion organization 30.7692 5 no
GO:0006109 regulation of carbohydrate metabolic process 30.7692 5 no
GO:0008104 protein localization 30.7692 4 no
GO:0010506 regulation of autophagy 30.7692 6 no
GO:0010628 positive regulation of gene expression 23.0769 7 no
GO:0010638 positive regulation of organelle organization 23.0769 6 no
GO:0010639 negative regulation of organelle organization 23.0769 6 no
GO:0031331 positive regulation of cellular catabolic process 23.0769 6 no
GO:0032386 regulation of intracellular transport 23.0769 5 no
GO:0032388 positive regulation of intracellular transport 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0034599 cellular response to oxidative stress 23.0769 4 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043393 regulation of protein binding 23.0769 4 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0043524 negative regulation of neuron apoptotic process 23.0769 7 no
GO:0045892 negative regulation of DNA-templated transcription 23.0769 8 no
GO:0046883 regulation of hormone secretion 23.0769 4 no
GO:0051048 negative regulation of secretion 23.0769 5 no
GO:0051223 regulation of protein transport 23.0769 5 no
GO:0051253 negative regulation of RNA metabolic process 23.0769 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0051952 regulation of amine transport 23.0769 5 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0061136 regulation of proteasomal protein catabolic process 23.0769 6 no
GO:0062197 cellular response to chemical stress 23.0769 4 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0098657 import into cell 23.0769 4 no
GO:1902679 negative regulation of RNA biosynthetic process 23.0769 7 no
GO:0006937 regulation of muscle contraction 23.0769 6 yes
GO:1903531 negative regulation of secretion by cell 23.0769 5 no
GO:0006942 regulation of striated muscle contraction 23.0769 7 yes
GO:0008016 regulation of heart contraction 23.0769 6 yes
GO:1990000 amyloid fibril formation 23.0769 4 no
GO:2000377 regulation of reactive oxygen species metabolic process 23.0769 5 no
GO:0006140 regulation of nucleotide metabolic process 23.0769 5 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23.0769 6 yes
GO:0009895 negative regulation of catabolic process 23.0769 5 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 23.0769 7 yes
GO:0043467 regulation of generation of precursor metabolites and energy 23.0769 5 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 23.0769 6 yes
GO:0045913 positive regulation of carbohydrate metabolic process 23.0769 5 no
GO:0062013 positive regulation of small molecule metabolic process 23.0769 5 no
GO:0014070 response to organic cyclic compound 23.0769 4 yes
GO:1900542 regulation of purine nucleotide metabolic process 23.0769 6 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0016053 organic acid biosynthetic process 23.0769 4 yes
GO:0018916 nitrobenzene metabolic process 23.0769 5 yes
GO:0019722 calcium-mediated signaling 23.0769 5 yes
GO:0032410 negative regulation of transporter activity 23.0769 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 23.0769 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 23.0769 6 yes
GO:0042178 xenobiotic catabolic process 23.0769 4 yes
GO:0042537 benzene-containing compound metabolic process 23.0769 4 yes
GO:0043270 positive regulation of monoatomic ion transport 23.0769 5 yes
GO:0046394 carboxylic acid biosynthetic process 23.0769 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 23.0769 6 yes
GO:0051928 positive regulation of calcium ion transport 23.0769 6 yes
GO:0055117 regulation of cardiac muscle contraction 23.0769 7 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 23.0769 6 yes
GO:0071407 cellular response to organic cyclic compound 23.0769 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 23.0769 6 yes
GO:0090257 regulation of muscle system process 23.0769 5 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.0769 6 yes
GO:1903522 regulation of blood circulation 23.0769 5 yes
GO:1904064 positive regulation of cation transmembrane transport 23.0769 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 23.0769 7 yes
GO:2001257 regulation of cation channel activity 23.0769 6 yes
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0006915 apoptotic process 23.0769 4 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0007268 chemical synaptic transmission 23.0769 7 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0034329 cell junction assembly 23.0769 5 no
GO:0048638 regulation of developmental growth 23.0769 4 no
GO:0050767 regulation of neurogenesis 23.0769 6 no
GO:0050770 regulation of axonogenesis 23.0769 5 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0051960 regulation of nervous system development 23.0769 5 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0070925 organelle assembly 23.0769 5 no
GO:0098916 anterograde trans-synaptic signaling 23.0769 6 no
GO:0099536 synaptic signaling 23.0769 4 no
GO:0099537 trans-synaptic signaling 23.0769 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:1902532 negative regulation of intracellular signal transduction 23.0769 6 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 23.0769 8 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.0769 5 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 23.0769 6 no
GO:0016070 RNA metabolic process 23.0769 5 no
GO:0051259 protein complex oligomerization 23.0769 6 no
GO:0090304 nucleic acid metabolic process 23.0769 4 no
GO:1901565 organonitrogen compound catabolic process 23.0769 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 23.0769 9 no
GO:0001558 regulation of cell growth 23.0769 4 no
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 8 no
GO:0006508 proteolysis 23.0769 4 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0001676 long-chain fatty acid metabolic process 15.3846 5 yes
GO:0006633 fatty acid biosynthetic process 15.3846 5 yes
GO:0014074 response to purine-containing compound 15.3846 5 yes
GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling 15.3846 6 yes
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 15.3846 7 yes
GO:0014819 regulation of skeletal muscle contraction 15.3846 8 yes
GO:0031000 response to caffeine 15.3846 6 yes
GO:0032411 positive regulation of transporter activity 15.3846 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 15.3846 5 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 15.3846 5 yes
GO:0033559 unsaturated fatty acid metabolic process 15.3846 5 yes
GO:0034763 negative regulation of transmembrane transport 15.3846 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 15.3846 6 yes
GO:0042759 long-chain fatty acid biosynthetic process 15.3846 6 yes
GO:0043271 negative regulation of monoatomic ion transport 15.3846 5 yes
GO:0043279 response to alkaloid 15.3846 5 yes
GO:0043651 linoleic acid metabolic process 15.3846 4 yes
GO:0051121 hepoxilin metabolic process 15.3846 6 yes
GO:0051122 hepoxilin biosynthetic process 15.3846 7 yes
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 15.3846 6 yes
GO:0051284 positive regulation of sequestering of calcium ion 15.3846 5 yes
GO:0051926 negative regulation of calcium ion transport 15.3846 6 yes
GO:0055119 relaxation of cardiac muscle 15.3846 5 yes
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 15.3846 7 yes
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 15.3846 7 yes
GO:0071312 cellular response to alkaloid 15.3846 5 yes
GO:0071313 cellular response to caffeine 15.3846 6 yes
GO:0071415 cellular response to purine-containing compound 15.3846 5 yes
GO:0090075 relaxation of muscle 15.3846 4 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 15.3846 6 yes
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 15.3846 6 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 15.3846 7 yes
GO:1904063 negative regulation of cation transmembrane transport 15.3846 7 yes
GO:2001258 negative regulation of cation channel activity 15.3846 6 yes
GO:2001259 positive regulation of cation channel activity 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K5_HUMAN [view interactions] Low throughput no yes
GSTM3_HUMAN [view entry] [view interactions] Low throughput yes yes
GSTM1_HUMAN [view interactions] Low throughput no yes
GSTM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
GSTM5_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CBL_HUMAN [view interactions] High throughput no yes
SPAG6_HUMAN [view interactions] High throughput no no
GSTM4_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
KCD15_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
RPAB2_HUMAN [view interactions] High throughput no yes
NALP7_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
AIMP2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
ASXL3_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no