Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GSTM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GSTM2_HUMAN
GO:0004364 glutathione transferase activity 33.3333 4 yes
GO:0042803 protein homodimerization activity 25.0000 4 yes
GO:1900750 oligopeptide binding 25.0000 4 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0031406 carboxylic acid binding 16.6667 4 yes
GO:0033293 monocarboxylic acid binding 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GSTM2_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0051049 regulation of transport 58.3333 4 yes
GO:0071310 cellular response to organic substance 58.3333 4 yes
GO:0006518 peptide metabolic process 50.0000 4 yes
GO:0019752 carboxylic acid metabolic process 50.0000 5 yes
GO:0043436 oxoacid metabolic process 50.0000 4 yes
GO:0043603 cellular amide metabolic process 50.0000 4 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0006749 glutathione metabolic process 41.6667 4 yes
GO:0010243 response to organonitrogen compound 41.6667 4 yes
GO:0034762 regulation of transmembrane transport 41.6667 4 yes
GO:0034764 positive regulation of transmembrane transport 41.6667 5 yes
GO:0034765 regulation of ion transmembrane transport 41.6667 5 yes
GO:0034767 positive regulation of ion transmembrane transport 41.6667 6 yes
GO:0043269 regulation of ion transport 41.6667 5 yes
GO:0043270 positive regulation of ion transport 41.6667 5 yes
GO:0044057 regulation of system process 41.6667 4 yes
GO:0051050 positive regulation of transport 41.6667 4 yes
GO:0051051 negative regulation of transport 41.6667 4 yes
GO:0022607 cellular component assembly 41.6667 4 no
GO:0043412 macromolecule modification 41.6667 4 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010468 regulation of gene expression 41.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0051129 negative regulation of cellular component organization 41.6667 5 no
GO:0051171 regulation of nitrogen compound metabolic process 41.6667 4 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0006631 fatty acid metabolic process 33.3333 4 yes
GO:0008610 lipid biosynthetic process 33.3333 4 yes
GO:0010959 regulation of metal ion transport 33.3333 6 yes
GO:0016053 organic acid biosynthetic process 33.3333 4 yes
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 yes
GO:0032411 positive regulation of transporter activity 33.3333 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 33.3333 5 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 33.3333 5 yes
GO:0032787 monocarboxylic acid metabolic process 33.3333 6 yes
GO:0042178 xenobiotic catabolic process 33.3333 4 yes
GO:0046394 carboxylic acid biosynthetic process 33.3333 5 yes
GO:0051924 regulation of calcium ion transport 33.3333 7 yes
GO:0051928 positive regulation of calcium ion transport 33.3333 6 yes
GO:0071417 cellular response to organonitrogen compound 33.3333 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 33.3333 6 yes
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 33.3333 6 yes
GO:1901699 cellular response to nitrogen compound 33.3333 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 yes
GO:1904062 regulation of cation transmembrane transport 33.3333 6 yes
GO:1904064 positive regulation of cation transmembrane transport 33.3333 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 33.3333 7 yes
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 25.0000 7 no
GO:2001233 regulation of apoptotic signaling pathway 25.0000 5 no
GO:0001676 long-chain fatty acid metabolic process 25.0000 5 yes
GO:0006937 regulation of muscle contraction 25.0000 6 yes
GO:0006942 regulation of striated muscle contraction 25.0000 7 yes
GO:0008016 regulation of heart contraction 25.0000 6 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 25.0000 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 25.0000 7 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 25.0000 6 yes
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling 25.0000 6 yes
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 25.0000 7 yes
GO:0014819 regulation of skeletal muscle contraction 25.0000 8 yes
GO:0019722 calcium-mediated signaling 25.0000 5 yes
GO:0019932 second-messenger-mediated signaling 25.0000 4 yes
GO:0032410 negative regulation of transporter activity 25.0000 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 25.0000 5 yes
GO:0033559 unsaturated fatty acid metabolic process 25.0000 5 yes
GO:0034763 negative regulation of transmembrane transport 25.0000 5 yes
GO:0034766 negative regulation of ion transmembrane transport 25.0000 6 yes
GO:0042537 benzene-containing compound metabolic process 25.0000 4 yes
GO:0043271 negative regulation of ion transport 25.0000 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 25.0000 5 yes
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 25.0000 6 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 25.0000 6 yes
GO:0051282 regulation of sequestering of calcium ion 25.0000 4 yes
GO:0051284 positive regulation of sequestering of calcium ion 25.0000 5 yes
GO:0051926 negative regulation of calcium ion transport 25.0000 6 yes
GO:0055117 regulation of cardiac muscle contraction 25.0000 7 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 25.0000 6 yes
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 25.0000 7 yes
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 25.0000 7 yes
GO:0072330 monocarboxylic acid biosynthetic process 25.0000 6 yes
GO:0090257 regulation of muscle system process 25.0000 5 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 25.0000 6 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 25.0000 7 yes
GO:1903522 regulation of blood circulation 25.0000 5 yes
GO:1904063 negative regulation of cation transmembrane transport 25.0000 7 yes
GO:2001257 regulation of cation channel activity 25.0000 6 yes
GO:2001258 negative regulation of cation channel activity 25.0000 6 yes
GO:2001259 positive regulation of cation channel activity 25.0000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010629 negative regulation of gene expression 25.0000 6 no
GO:0010942 positive regulation of cell death 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050767 regulation of neurogenesis 25.0000 6 no
GO:0050770 regulation of axonogenesis 25.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050808 synapse organization 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0006633 fatty acid biosynthetic process 16.6667 5 yes
GO:0014074 response to purine-containing compound 16.6667 5 yes
GO:0031000 response to caffeine 16.6667 6 yes
GO:0042759 long-chain fatty acid biosynthetic process 16.6667 6 yes
GO:0043279 response to alkaloid 16.6667 5 yes
GO:0043651 linoleic acid metabolic process 16.6667 4 yes
GO:0051121 hepoxilin metabolic process 16.6667 6 yes
GO:0051122 hepoxilin biosynthetic process 16.6667 7 yes
GO:0055119 relaxation of cardiac muscle 16.6667 5 yes
GO:0071312 cellular response to alkaloid 16.6667 5 yes
GO:0071313 cellular response to caffeine 16.6667 6 yes
GO:0071407 cellular response to organic cyclic compound 16.6667 5 yes
GO:0071415 cellular response to purine-containing compound 16.6667 5 yes
GO:0090075 relaxation of muscle 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K5_HUMAN [view interactions] Low throughput no yes
GSTM3_HUMAN [view entry] [view interactions] Low throughput yes yes
GSTM1_HUMAN [view interactions] Low throughput no yes
GSTM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
GSTM5_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CBL_HUMAN [view interactions] High throughput no yes
GSTM4_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
KCD15_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
RPAB2_HUMAN [view interactions] High throughput no yes
NALP7_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
GPX1_HUMAN [view entry] [view interactions] Computational yes yes
GPX3_HUMAN [view interactions] Computational no no
MGST1_HUMAN [view interactions] Computational no no
GPX6_HUMAN [view interactions] Computational no no
GSTA4_HUMAN [view interactions] Computational no yes
CP2E1_HUMAN [view interactions] Computational no no
GPX7_HUMAN [view interactions] Computational no no
CP1A1_HUMAN [view interactions] Computational no yes
GPX8_HUMAN [view interactions] Computational no no
HYEP_HUMAN [view interactions] Computational no no
GSTT2_HUMAN [view interactions] Computational no no