Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PERE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PERE_HUMAN
GO:0043169 cation binding 75.0000 4 yes
GO:0046872 metal ion binding 75.0000 5 yes
GO:0020037 heme binding 50.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PERE_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0002683 negative regulation of immune system process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 75.0000 4 yes
GO:2000145 regulation of cell motility 50.0000 4 no
GO:2000147 positive regulation of cell motility 50.0000 5 no
GO:0001817 regulation of cytokine production 50.0000 4 yes
GO:0001818 negative regulation of cytokine production 50.0000 5 yes
GO:0001819 positive regulation of cytokine production 50.0000 5 yes
GO:0002215 defense response to nematode 50.0000 4 yes
GO:0002697 regulation of immune effector process 50.0000 4 yes
GO:0002698 negative regulation of immune effector process 50.0000 5 yes
GO:0002700 regulation of production of molecular mediator of immune response 50.0000 5 yes
GO:0002701 negative regulation of production of molecular mediator of immune response 50.0000 6 yes
GO:0002718 regulation of cytokine production involved in immune response 50.0000 5 yes
GO:0002719 negative regulation of cytokine production involved in immune response 50.0000 6 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0009890 negative regulation of biosynthetic process 50.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 50.0000 5 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 50.0000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010628 positive regulation of gene expression 50.0000 7 yes
GO:0010629 negative regulation of gene expression 50.0000 7 yes
GO:0010935 regulation of macrophage cytokine production 50.0000 6 yes
GO:0010936 negative regulation of macrophage cytokine production 50.0000 7 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0031324 negative regulation of cellular metabolic process 50.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 50.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 yes
GO:0032653 regulation of interleukin-10 production 50.0000 5 yes
GO:0032673 regulation of interleukin-4 production 50.0000 5 yes
GO:0032674 regulation of interleukin-5 production 50.0000 5 yes
GO:0032693 negative regulation of interleukin-10 production 50.0000 6 yes
GO:0032714 negative regulation of interleukin-5 production 50.0000 6 yes
GO:0032753 positive regulation of interleukin-4 production 50.0000 6 yes
GO:0042742 defense response to bacterium 50.0000 4 yes
GO:0042743 hydrogen peroxide metabolic process 50.0000 4 yes
GO:0042744 hydrogen peroxide catabolic process 50.0000 4 yes
GO:0051241 negative regulation of multicellular organismal process 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0072677 eosinophil migration 50.0000 5 yes
GO:0097530 granulocyte migration 50.0000 4 yes
GO:0010632 regulation of epithelial cell migration 50.0000 4 no
GO:0010634 positive regulation of epithelial cell migration 50.0000 5 no
GO:0030334 regulation of cell migration 50.0000 5 no
GO:0030335 positive regulation of cell migration 50.0000 6 no
GO:0040017 positive regulation of locomotion 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PERE_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
TM237_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TTC19_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
O13C3_HUMAN [view interactions] High throughput no no
TMM74_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
STYL2_HUMAN [view interactions] High throughput no no