Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BLNK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004408 LIG_SH3_CIN85_PxpxPR_1 LIG 242 247 -
ELMI004409 LIG_SH3_CIN85_PxpxPR_1 LIG 307 312 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BLNK_HUMAN
GO:0005524 ATP binding 40.0000 5 no
GO:0017076 purine nucleotide binding 40.0000 4 no
GO:0030554 adenyl nucleotide binding 40.0000 5 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0019900 kinase binding 36.0000 4 yes
GO:0019901 protein kinase binding 36.0000 5 yes
GO:0001784 phosphotyrosine residue binding 32.0000 5 no
GO:0045309 protein phosphorylated amino acid binding 32.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 32.0000 4 no
GO:0016301 kinase activity 32.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 32.0000 4 no
GO:0004713 protein tyrosine kinase activity 28.0000 4 no
GO:0045296 cadherin binding 28.0000 4 no
GO:0070851 growth factor receptor binding 24.0000 4 no
GO:0030971 receptor tyrosine kinase binding 16.0000 4 yes
GO:0043274 phospholipase binding 16.0000 4 yes
GO:1990782 protein tyrosine kinase binding 16.0000 6 yes
GO:0030159 signaling receptor complex adaptor activity 12.0000 4 yes
GO:0042169 SH2 domain binding 12.0000 4 yes
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 8.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BLNK_HUMAN
GO:0048522 positive regulation of cellular process 68.0000 4 no
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 56.0000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 56.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 56.0000 4 yes
GO:0031323 regulation of cellular metabolic process 56.0000 4 no
GO:0048523 negative regulation of cellular process 56.0000 4 no
GO:0002684 positive regulation of immune system process 52.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.0000 5 yes
GO:0048584 positive regulation of response to stimulus 52.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.0000 4 no
GO:0080090 regulation of primary metabolic process 52.0000 4 no
GO:0009966 regulation of signal transduction 48.0000 4 no
GO:0010646 regulation of cell communication 48.0000 4 no
GO:0051128 regulation of cellular component organization 48.0000 4 no
GO:0051246 regulation of protein metabolic process 48.0000 5 no
GO:1902531 regulation of intracellular signal transduction 48.0000 5 no
GO:0006996 organelle organization 48.0000 4 no
GO:0050776 regulation of immune response 44.0000 4 yes
GO:0071310 cellular response to organic substance 44.0000 4 no
GO:0019220 regulation of phosphate metabolic process 44.0000 6 no
GO:0022607 cellular component assembly 44.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 44.0000 5 no
GO:0042325 regulation of phosphorylation 44.0000 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 44.0000 5 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 40.0000 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 40.0000 4 yes
GO:0010468 regulation of gene expression 40.0000 5 yes
GO:0050778 positive regulation of immune response 40.0000 5 yes
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0002694 regulation of leukocyte activation 40.0000 4 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0050865 regulation of cell activation 40.0000 4 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0043085 positive regulation of catalytic activity 40.0000 4 no
GO:0051336 regulation of hydrolase activity 40.0000 4 no
GO:0010941 regulation of cell death 36.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 36.0000 4 no
GO:0051049 regulation of transport 36.0000 4 no
GO:0010647 positive regulation of cell communication 36.0000 5 no
GO:0023056 positive regulation of signaling 36.0000 4 no
GO:0030155 regulation of cell adhesion 36.0000 4 no
GO:0045785 positive regulation of cell adhesion 36.0000 5 no
GO:0051249 regulation of lymphocyte activation 36.0000 5 no
GO:0007010 cytoskeleton organization 36.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 32.0000 4 no
GO:0042127 regulation of cell population proliferation 32.0000 4 no
GO:0042981 regulation of apoptotic process 32.0000 6 no
GO:0043067 regulation of programmed cell death 32.0000 5 no
GO:0070848 response to growth factor 32.0000 4 no
GO:0080134 regulation of response to stress 32.0000 4 no
GO:0002696 positive regulation of leukocyte activation 32.0000 5 no
GO:0009889 regulation of biosynthetic process 32.0000 4 no
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0009967 positive regulation of signal transduction 32.0000 5 no
GO:0022407 regulation of cell-cell adhesion 32.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 32.0000 5 no
GO:0043933 protein-containing complex organization 32.0000 4 no
GO:0050863 regulation of T cell activation 32.0000 6 no
GO:0050867 positive regulation of cell activation 32.0000 5 no
GO:0051251 positive regulation of lymphocyte activation 32.0000 6 no
GO:0051338 regulation of transferase activity 32.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 32.0000 6 no
GO:1903037 regulation of leukocyte cell-cell adhesion 32.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 32.0000 6 no
GO:0036211 protein modification process 32.0000 4 no
GO:0042327 positive regulation of phosphorylation 32.0000 8 no
GO:0043412 macromolecule modification 32.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 32.0000 7 no
GO:0050851 antigen receptor-mediated signaling pathway 28.0000 5 yes
GO:0002683 negative regulation of immune system process 28.0000 4 no
GO:0008284 positive regulation of cell population proliferation 28.0000 5 no
GO:0010942 positive regulation of cell death 28.0000 5 no
GO:0032101 regulation of response to external stimulus 28.0000 4 no
GO:0048585 negative regulation of response to stimulus 28.0000 4 no
GO:0071363 cellular response to growth factor stimulus 28.0000 5 no
GO:0009891 positive regulation of biosynthetic process 28.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.0000 5 no
GO:0022409 positive regulation of cell-cell adhesion 28.0000 6 no
GO:0030030 cell projection organization 28.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0033043 regulation of organelle organization 28.0000 5 no
GO:0043549 regulation of kinase activity 28.0000 5 no
GO:0050870 positive regulation of T cell activation 28.0000 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.0000 5 no
GO:0065003 protein-containing complex assembly 28.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.0000 5 no
GO:1903039 positive regulation of leukocyte cell-cell adhesion 28.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 28.0000 8 no
GO:0031401 positive regulation of protein modification process 28.0000 7 no
GO:1901701 cellular response to oxygen-containing compound 28.0000 4 no
GO:0043408 regulation of MAPK cascade 28.0000 6 no
GO:0051345 positive regulation of hydrolase activity 28.0000 5 no
GO:0006468 protein phosphorylation 28.0000 5 no
GO:0016310 phosphorylation 28.0000 5 no
GO:0030334 regulation of cell migration 24.0000 5 no
GO:0031347 regulation of defense response 24.0000 5 no
GO:0031348 negative regulation of defense response 24.0000 5 no
GO:0032102 negative regulation of response to external stimulus 24.0000 5 no
GO:0038093 Fc receptor signaling pathway 24.0000 5 no
GO:0038127 ERBB signaling pathway 24.0000 6 no
GO:0043065 positive regulation of apoptotic process 24.0000 7 no
GO:0043068 positive regulation of programmed cell death 24.0000 6 no
GO:0050727 regulation of inflammatory response 24.0000 5 no
GO:0050728 negative regulation of inflammatory response 24.0000 6 no
GO:0050777 negative regulation of immune response 24.0000 5 no
GO:0051050 positive regulation of transport 24.0000 4 no
GO:2000145 regulation of cell motility 24.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 24.0000 6 no
GO:0032535 regulation of cellular component size 24.0000 4 no
GO:0043254 regulation of protein-containing complex assembly 24.0000 5 no
GO:0044087 regulation of cellular component biogenesis 24.0000 4 no
GO:0045859 regulation of protein kinase activity 24.0000 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.0000 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 24.0000 8 no
GO:0051130 positive regulation of cellular component organization 24.0000 5 no
GO:0051248 negative regulation of protein metabolic process 24.0000 6 no
GO:0051493 regulation of cytoskeleton organization 24.0000 6 no
GO:0034330 cell junction organization 24.0000 4 no
GO:0060341 regulation of cellular localization 24.0000 4 no
GO:0018193 peptidyl-amino acid modification 24.0000 5 no
GO:0030162 regulation of proteolysis 24.0000 6 no
GO:0052547 regulation of peptidase activity 24.0000 5 no
GO:0052548 regulation of endopeptidase activity 24.0000 6 no
GO:0010628 positive regulation of gene expression 20.0000 6 yes
GO:0050853 B cell receptor signaling pathway 16.0000 6 yes
GO:0002521 leukocyte differentiation 12.0000 4 yes
GO:1903131 mononuclear cell differentiation 12.0000 5 yes
GO:0030098 lymphocyte differentiation 8.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRAP2_HUMAN [view interactions] Low throughput no no
BTK_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITK_HUMAN [view interactions] Low throughput no no
KSYK_HUMAN [view interactions] Low throughput no no
M4K1_HUMAN [view interactions] Low throughput no no
CD2AP_HUMAN [view interactions] Low throughput no no
MP2K4_HUMAN [view interactions] Low throughput no yes
DOK3_HUMAN [view interactions] Low throughput no no
PLCG2_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
VAV_HUMAN [view interactions] Low throughput no no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
CD79A_HUMAN [view interactions] Low throughput no no
CD72_HUMAN [view interactions] Low throughput no no
PTN6_HUMAN [view interactions] Low throughput no no
CKLF3_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
BANP_HUMAN [view interactions] High throughput no yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SCIMP_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ANDR_HUMAN [view interactions] High throughput no no
GAB1_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
CL17A_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
VAV3_HUMAN [view interactions] High throughput no yes
2ABG_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
WDR81_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
LCK_HUMAN [view entry] [view interactions] Computational yes no
BCR_HUMAN [view entry] [view interactions] Computational yes yes
BLK_HUMAN [view interactions] Computational no no
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
BCAP_HUMAN [view interactions] Computational no no
CD79B_HUMAN [view interactions] Computational no no
LAT_HUMAN [view interactions] Computational no no
FGR_HUMAN [view interactions] Computational no no
3BP5_HUMAN [view interactions] Computational no yes
LCP2_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
VAV2_HUMAN [view entry] [view interactions] Computational yes yes
IBTK_HUMAN [view interactions] Computational no yes
TEC_HUMAN [view interactions] Computational no yes
ZAP70_HUMAN [view interactions] Computational no no
BCL6_HUMAN [view interactions] Computational no no
YES_HUMAN [view entry] [view interactions] Computational yes yes