Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BLNK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004408 LIG_SH3_CIN85_PxpxPR_1 LIG 242 247 -
ELMI004409 LIG_SH3_CIN85_PxpxPR_1 LIG 307 312 -
ELMI004787 LIG_SH3_PxxxRxxKP_6 LIG 204 212 -
ELMI004408 LIG_SH3_CIN85_PxpxPR_1 LIG 242 247 -
ELMI004409 LIG_SH3_CIN85_PxpxPR_1 LIG 307 312 -
ELMI004787 LIG_SH3_PxxxRxxKP_6 LIG 204 212 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BLNK_HUMAN
GO:0019900 kinase binding 38.8889 4 yes
GO:0019901 protein kinase binding 38.8889 5 yes
GO:0030971 receptor tyrosine kinase binding 33.3333 4 yes
GO:1990782 protein tyrosine kinase binding 33.3333 6 yes
GO:0000166 nucleotide binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0045296 cadherin binding 33.3333 4 no
GO:0005524 ATP binding 27.7778 5 no
GO:0017076 purine nucleotide binding 27.7778 5 no
GO:0030554 adenyl nucleotide binding 27.7778 6 no
GO:0032555 purine ribonucleotide binding 27.7778 4 no
GO:0032559 adenyl ribonucleotide binding 27.7778 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.7778 4 no
GO:0001784 phosphotyrosine residue binding 22.2222 5 no
GO:0045309 protein phosphorylated amino acid binding 22.2222 4 no
GO:0003779 actin binding 22.2222 4 no
GO:0030159 signaling receptor complex adaptor activity 16.6667 4 yes
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BLNK_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0051128 regulation of cellular component organization 61.1111 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0006996 organelle organization 55.5556 4 no
GO:0002684 positive regulation of immune system process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0022607 cellular component assembly 44.4444 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 44.4444 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 44.4444 5 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 yes
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 yes
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0010646 regulation of cell communication 38.8889 4 no
GO:0042127 regulation of cell population proliferation 38.8889 4 no
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:0080090 regulation of primary metabolic process 38.8889 4 no
GO:0043933 protein-containing complex organization 38.8889 4 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 33.3333 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 yes
GO:0050776 regulation of immune response 33.3333 4 yes
GO:0050778 positive regulation of immune response 33.3333 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 33.3333 5 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0010647 positive regulation of cell communication 27.7778 5 no
GO:0023056 positive regulation of signaling 27.7778 4 no
GO:0030030 cell projection organization 27.7778 4 no
GO:0043408 regulation of MAPK cascade 27.7778 6 no
GO:0045785 positive regulation of cell adhesion 27.7778 5 no
GO:0050865 regulation of cell activation 27.7778 4 no
GO:0051240 positive regulation of multicellular organismal process 27.7778 4 no
GO:0051249 regulation of lymphocyte activation 27.7778 5 no
GO:0120036 plasma membrane bounded cell projection organization 27.7778 5 no
GO:0141124 intracellular signaling cassette 27.7778 4 no
GO:0008064 regulation of actin polymerization or depolymerization 27.7778 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0030832 regulation of actin filament length 27.7778 5 no
GO:0030833 regulation of actin filament polymerization 27.7778 7 no
GO:0032271 regulation of protein polymerization 27.7778 6 no
GO:0032535 regulation of cellular component size 27.7778 4 no
GO:0032956 regulation of actin cytoskeleton organization 27.7778 5 no
GO:0032970 regulation of actin filament-based process 27.7778 4 no
GO:0038127 ERBB signaling pathway 27.7778 6 no
GO:0043254 regulation of protein-containing complex assembly 27.7778 5 no
GO:0110053 regulation of actin filament organization 27.7778 6 no
GO:1902903 regulation of supramolecular fiber organization 27.7778 5 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 yes
GO:0002694 regulation of leukocyte activation 27.7778 4 no
GO:0002696 positive regulation of leukocyte activation 22.2222 5 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0006974 DNA damage response 22.2222 4 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0021782 glial cell development 22.2222 4 no
GO:0022407 regulation of cell-cell adhesion 22.2222 5 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043065 positive regulation of apoptotic process 22.2222 6 no
GO:0043068 positive regulation of programmed cell death 22.2222 5 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0050863 regulation of T cell activation 22.2222 6 no
GO:0050867 positive regulation of cell activation 22.2222 5 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051251 positive regulation of lymphocyte activation 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0070663 regulation of leukocyte proliferation 22.2222 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:1903037 regulation of leukocyte cell-cell adhesion 22.2222 6 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0007173 epidermal growth factor receptor signaling pathway 22.2222 7 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0008104 protein localization 22.2222 4 no
GO:0050853 B cell receptor signaling pathway 22.2222 6 yes
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010628 positive regulation of gene expression 16.6667 7 yes
GO:0002521 leukocyte differentiation 11.1111 4 yes
GO:1903131 mononuclear cell differentiation 11.1111 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRAP2_HUMAN [view interactions] Low throughput no no
BTK_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITK_HUMAN [view interactions] Low throughput no no
KSYK_HUMAN [view interactions] Low throughput no no
M4K1_HUMAN [view interactions] Low throughput no no
CD2AP_HUMAN [view interactions] Low throughput no no
PLCG2_HUMAN [view interactions] Low throughput no yes
DOK3_HUMAN [view interactions] Low throughput no no
MP2K4_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
VAV_HUMAN [view interactions] Low throughput no no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
CD79A_HUMAN [view interactions] Low throughput no no
CD72_HUMAN [view interactions] Low throughput no no
PTN6_HUMAN [view interactions] Low throughput no no
CKLF3_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
BANP_HUMAN [view interactions] High throughput no yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SCIMP_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ANDR_HUMAN [view interactions] High throughput no no
GAB1_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
CL17A_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
VAV3_HUMAN [view interactions] High throughput no yes
2ABG_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
WDR81_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes