ADCY8_HUMAN
Evidence for PS localization
Functions
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Close ✖
ADCY8_HUMAN has binary interactions with 9 proteins
Isoforms
Interacting regions
Canonical [ADCY8_HUMAN]
Isoform [E7EVL1] alignment
Isoform [E5RFR2] alignment
LOADING 72%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADCY8_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 60.0000 | 5 | yes |
| GO:0019888 | protein phosphatase regulator activity | 40.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | yes |
| GO:0043168 | anion binding | 30.0000 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 30.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 30.0000 | 6 | no |
| GO:0008200 | ion channel inhibitor activity | 30.0000 | 5 | no |
| GO:0010853 | cyclase activator activity | 30.0000 | 4 | no |
| GO:0010854 | adenylate cyclase regulator activity | 30.0000 | 4 | no |
| GO:0010856 | adenylate cyclase activator activity | 30.0000 | 5 | no |
| GO:0016248 | channel inhibitor activity | 30.0000 | 4 | no |
| GO:0019209 | kinase activator activity | 30.0000 | 4 | no |
| GO:0019211 | phosphatase activator activity | 30.0000 | 4 | no |
| GO:0019887 | protein kinase regulator activity | 30.0000 | 4 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 30.0000 | 5 | no |
| GO:0030295 | protein kinase activator activity | 30.0000 | 5 | no |
| GO:0031432 | titin binding | 30.0000 | 4 | no |
| GO:0043539 | protein serine/threonine kinase activator activity | 30.0000 | 6 | no |
| GO:0072542 | protein phosphatase activator activity | 30.0000 | 5 | no |
| GO:0099106 | ion channel regulator activity | 30.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADCY8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 70.0000 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 70.0000 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 70.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 70.0000 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 70.0000 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 70.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 70.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 70.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 70.0000 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 60.0000 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 60.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 60.0000 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 60.0000 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 60.0000 | 8 | yes |
| GO:0043085 | positive regulation of catalytic activity | 60.0000 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 60.0000 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 60.0000 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 60.0000 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 60.0000 | 8 | yes |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 50.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| HACD2_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PEX16_HUMAN | [view interactions] | High throughput | no | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |