Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADCY8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADCY8_HUMAN
GO:0017076 purine nucleotide binding 66.6667 4 yes
GO:0032555 purine ribonucleotide binding 66.6667 4 yes
GO:0046872 metal ion binding 66.6667 4 yes
GO:0030554 adenyl nucleotide binding 45.4545 5 yes
GO:0032559 adenyl ribonucleotide binding 45.4545 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 45.4545 4 yes
GO:0001664 G protein-coupled receptor binding 27.2727 4 no
GO:0005524 ATP binding 24.2424 5 yes
GO:0019900 kinase binding 24.2424 4 no
GO:0019901 protein kinase binding 24.2424 5 no
GO:0019001 guanyl nucleotide binding 24.2424 5 no
GO:0032561 guanyl ribonucleotide binding 24.2424 5 no
GO:0030551 cyclic nucleotide binding 21.2121 4 no
GO:0030552 cAMP binding 21.2121 4 no
GO:0003924 GTPase activity 21.2121 7 no
GO:0005525 GTP binding 21.2121 5 no
GO:0016462 pyrophosphatase activity 21.2121 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.2121 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.2121 6 no
GO:0042803 protein homodimerization activity 9.0909 4 yes
GO:0046982 protein heterodimerization activity 9.0909 4 yes
GO:0003779 actin binding 6.0606 4 yes
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity 6.0606 4 yes
GO:0019902 phosphatase binding 6.0606 4 yes
GO:0019903 protein phosphatase binding 6.0606 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADCY8_HUMAN
GO:0010646 regulation of cell communication 78.7879 4 yes
GO:0060255 regulation of macromolecule metabolic process 69.6970 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 63.6364 4 no
GO:0031323 regulation of cellular metabolic process 63.6364 4 yes
GO:0048522 positive regulation of cellular process 57.5758 4 yes
GO:0051246 regulation of protein metabolic process 57.5758 5 yes
GO:0009966 regulation of signal transduction 57.5758 4 no
GO:0051049 regulation of transport 48.4848 4 yes
GO:0006796 phosphate-containing compound metabolic process 48.4848 4 yes
GO:0009893 positive regulation of metabolic process 48.4848 4 yes
GO:0031399 regulation of protein modification process 48.4848 6 yes
GO:0009892 negative regulation of metabolic process 45.4545 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 45.4545 5 no
GO:1902531 regulation of intracellular signal transduction 45.4545 5 no
GO:0010468 regulation of gene expression 45.4545 5 yes
GO:0051174 regulation of phosphorus metabolic process 42.4242 5 yes
GO:0019220 regulation of phosphate metabolic process 42.4242 6 yes
GO:0031324 negative regulation of cellular metabolic process 39.3939 5 no
GO:0051248 negative regulation of protein metabolic process 39.3939 6 no
GO:0001932 regulation of protein phosphorylation 39.3939 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 39.3939 4 yes
GO:0042325 regulation of phosphorylation 39.3939 7 yes
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 yes
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 yes
GO:0031400 negative regulation of protein modification process 36.3636 7 no
GO:0010243 response to organonitrogen compound 36.3636 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051050 positive regulation of transport 30.3030 4 yes
GO:0051252 regulation of RNA metabolic process 30.3030 5 yes
GO:0001933 negative regulation of protein phosphorylation 30.3030 8 no
GO:0019932 second-messenger-mediated signaling 30.3030 4 no
GO:0036211 protein modification process 30.3030 4 no
GO:0042326 negative regulation of phosphorylation 30.3030 8 no
GO:0043412 macromolecule modification 30.3030 4 no
GO:0010941 regulation of cell death 30.3030 4 no
GO:0010959 regulation of metal ion transport 30.3030 6 no
GO:0042981 regulation of apoptotic process 30.3030 6 no
GO:0043067 regulation of programmed cell death 30.3030 5 no
GO:0043269 regulation of ion transport 30.3030 5 no
GO:0051924 regulation of calcium ion transport 30.3030 7 no
GO:0048584 positive regulation of response to stimulus 30.3030 4 no
GO:0010647 positive regulation of cell communication 30.3030 5 yes
GO:0014070 response to organic cyclic compound 30.3030 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3030 5 yes
GO:0023056 positive regulation of signaling 30.3030 4 yes
GO:0031325 positive regulation of cellular metabolic process 30.3030 5 yes
GO:0043085 positive regulation of catalytic activity 30.3030 4 yes
GO:0043549 regulation of kinase activity 27.2727 5 yes
GO:0045859 regulation of protein kinase activity 27.2727 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 27.2727 5 yes
GO:0051247 positive regulation of protein metabolic process 27.2727 6 yes
GO:0051338 regulation of transferase activity 27.2727 4 yes
GO:0071310 cellular response to organic substance 27.2727 4 yes
GO:1901701 cellular response to oxygen-containing compound 27.2727 4 yes
GO:0051128 regulation of cellular component organization 27.2727 4 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0009889 regulation of biosynthetic process 27.2727 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 yes
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 yes
GO:0060341 regulation of cellular localization 24.2424 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 24.2424 7 yes
GO:2001141 regulation of RNA biosynthetic process 24.2424 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 24.2424 7 no
GO:0043086 negative regulation of catalytic activity 24.2424 4 no
GO:0022898 regulation of transmembrane transporter activity 24.2424 4 no
GO:0032412 regulation of ion transmembrane transporter activity 24.2424 5 no
GO:0034762 regulation of transmembrane transport 24.2424 4 no
GO:0034765 regulation of ion transmembrane transport 24.2424 5 no
GO:0090257 regulation of muscle system process 24.2424 5 no
GO:1903169 regulation of calcium ion transmembrane transport 24.2424 7 no
GO:1904062 regulation of cation transmembrane transport 24.2424 6 no
GO:0006468 protein phosphorylation 24.2424 5 no
GO:0016310 phosphorylation 24.2424 5 no
GO:0006355 regulation of DNA-templated transcription 24.2424 6 yes
GO:0031401 positive regulation of protein modification process 24.2424 7 yes
GO:0045937 positive regulation of phosphate metabolic process 21.2121 7 yes
GO:0071407 cellular response to organic cyclic compound 21.2121 5 yes
GO:0010564 regulation of cell cycle process 21.2121 5 no
GO:0051240 positive regulation of multicellular organismal process 21.2121 4 no
GO:0006937 regulation of muscle contraction 21.2121 6 no
GO:0006942 regulation of striated muscle contraction 21.2121 7 no
GO:0008016 regulation of heart contraction 21.2121 6 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 21.2121 5 no
GO:0051282 regulation of sequestering of calcium ion 21.2121 4 no
GO:0051336 regulation of hydrolase activity 21.2121 4 no
GO:0055117 regulation of cardiac muscle contraction 21.2121 7 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 21.2121 6 no
GO:1903522 regulation of blood circulation 21.2121 5 no
GO:2001257 regulation of cation channel activity 21.2121 6 no
GO:0001934 positive regulation of protein phosphorylation 21.2121 8 yes
GO:0010038 response to metal ion 21.2121 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 21.2121 6 yes
GO:0032880 regulation of protein localization 21.2121 5 yes
GO:0042327 positive regulation of phosphorylation 21.2121 8 yes
GO:0045860 positive regulation of protein kinase activity 18.1818 7 yes
GO:0050890 cognition 18.1818 4 yes
GO:0051046 regulation of secretion 18.1818 5 yes
GO:0051347 positive regulation of transferase activity 18.1818 5 yes
GO:0051592 response to calcium ion 18.1818 5 yes
GO:0071417 cellular response to organonitrogen compound 18.1818 4 yes
GO:0072521 purine-containing compound metabolic process 18.1818 4 yes
GO:0097305 response to alcohol 18.1818 4 yes
GO:1901699 cellular response to nitrogen compound 18.1818 4 yes
GO:1903530 regulation of secretion by cell 18.1818 4 yes
GO:1903829 positive regulation of protein localization 18.1818 5 yes
GO:0006163 purine nucleotide metabolic process 18.1818 5 yes
GO:0006753 nucleoside phosphate metabolic process 18.1818 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 18.1818 5 yes
GO:0009117 nucleotide metabolic process 18.1818 5 yes
GO:0009150 purine ribonucleotide metabolic process 18.1818 6 yes
GO:0009259 ribonucleotide metabolic process 18.1818 5 yes
GO:0019693 ribose phosphate metabolic process 18.1818 4 yes
GO:0022607 cellular component assembly 18.1818 4 yes
GO:0033674 positive regulation of kinase activity 18.1818 6 yes
GO:0033993 response to lipid 18.1818 4 yes
GO:0048878 chemical homeostasis 15.1515 4 yes
GO:0050806 positive regulation of synaptic transmission 15.1515 5 yes
GO:0051222 positive regulation of protein transport 15.1515 5 yes
GO:0051223 regulation of protein transport 15.1515 5 yes
GO:0070201 regulation of establishment of protein localization 15.1515 6 yes
GO:0071396 cellular response to lipid 15.1515 5 yes
GO:0080134 regulation of response to stress 15.1515 4 yes
GO:1901654 response to ketone 15.1515 4 yes
GO:1904951 positive regulation of establishment of protein localization 15.1515 6 yes
GO:0009187 cyclic nucleotide metabolic process 15.1515 6 yes
GO:0043933 protein-containing complex organization 12.1212 4 yes
GO:0046058 cAMP metabolic process 12.1212 7 yes
GO:0050801 ion homeostasis 12.1212 5 yes
GO:0055065 metal ion homeostasis 12.1212 7 yes
GO:0055074 calcium ion homeostasis 12.1212 8 yes
GO:0055080 cation homeostasis 12.1212 6 yes
GO:0065003 protein-containing complex assembly 12.1212 5 yes
GO:0072503 cellular divalent inorganic cation homeostasis 12.1212 6 yes
GO:0072507 divalent inorganic cation homeostasis 12.1212 7 yes
GO:0097306 cellular response to alcohol 12.1212 5 yes
GO:0098771 inorganic ion homeostasis 12.1212 6 yes
GO:1901655 cellular response to ketone 12.1212 5 yes
GO:0006873 cellular ion homeostasis 12.1212 4 yes
GO:0006874 cellular calcium ion homeostasis 12.1212 7 yes
GO:0006875 cellular metal ion homeostasis 12.1212 6 yes
GO:0030003 cellular cation homeostasis 12.1212 5 yes
GO:0032870 cellular response to hormone stimulus 12.1212 4 yes
GO:0043434 response to peptide hormone 9.0909 4 yes
GO:0051047 positive regulation of secretion 9.0909 5 yes
GO:0071241 cellular response to inorganic substance 9.0909 4 yes
GO:0071248 cellular response to metal ion 9.0909 5 yes
GO:0071277 cellular response to calcium ion 9.0909 6 yes
GO:0080135 regulation of cellular response to stress 9.0909 4 yes
GO:1900271 regulation of long-term synaptic potentiation 9.0909 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 9.0909 5 yes
GO:1901652 response to peptide 9.0909 4 yes
GO:1904321 response to forskolin 9.0909 5 yes
GO:1904322 cellular response to forskolin 9.0909 6 yes
GO:0007613 memory 9.0909 4 yes
GO:0033500 carbohydrate homeostasis 9.0909 5 yes
GO:0042593 glucose homeostasis 9.0909 6 yes
GO:0044271 cellular nitrogen compound biosynthetic process 6.0606 4 yes
GO:0046390 ribose phosphate biosynthetic process 6.0606 5 yes
GO:0046883 regulation of hormone secretion 6.0606 4 yes
GO:0046887 positive regulation of hormone secretion 6.0606 5 yes
GO:0050708 regulation of protein secretion 6.0606 5 yes
GO:0050714 positive regulation of protein secretion 6.0606 6 yes
GO:0050796 regulation of insulin secretion 6.0606 6 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 6.0606 4 yes
GO:0051480 regulation of cytosolic calcium ion concentration 6.0606 8 yes
GO:0052652 cyclic purine nucleotide metabolic process 6.0606 7 yes
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 6.0606 7 yes
GO:0071322 cellular response to carbohydrate stimulus 6.0606 5 yes
GO:0071326 cellular response to monosaccharide stimulus 6.0606 6 yes
GO:0071331 cellular response to hexose stimulus 6.0606 7 yes
GO:0071333 cellular response to glucose stimulus 6.0606 5 yes
GO:0071375 cellular response to peptide hormone stimulus 6.0606 5 yes
GO:0072522 purine-containing compound biosynthetic process 6.0606 5 yes
GO:0090087 regulation of peptide transport 6.0606 5 yes
GO:0090276 regulation of peptide hormone secretion 6.0606 5 yes
GO:0090277 positive regulation of peptide hormone secretion 6.0606 6 yes
GO:0090407 organophosphate biosynthetic process 6.0606 4 yes
GO:0150076 neuroinflammatory response 6.0606 5 yes
GO:1901137 carbohydrate derivative biosynthetic process 6.0606 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 6.0606 5 yes
GO:1901362 organic cyclic compound biosynthetic process 6.0606 4 yes
GO:1901566 organonitrogen compound biosynthetic process 6.0606 4 yes
GO:1901653 cellular response to peptide 6.0606 5 yes
GO:1903532 positive regulation of secretion by cell 6.0606 5 yes
GO:0001678 cellular glucose homeostasis 6.0606 4 yes
GO:0002791 regulation of peptide secretion 6.0606 6 yes
GO:0002793 positive regulation of peptide secretion 6.0606 6 yes
GO:0006164 purine nucleotide biosynthetic process 6.0606 6 yes
GO:0006171 cAMP biosynthetic process 6.0606 8 yes
GO:0006954 inflammatory response 6.0606 4 yes
GO:0007616 long-term memory 6.0606 5 yes
GO:0009152 purine ribonucleotide biosynthetic process 6.0606 7 yes
GO:0009165 nucleotide biosynthetic process 6.0606 6 yes
GO:0009190 cyclic nucleotide biosynthetic process 6.0606 7 yes
GO:0009260 ribonucleotide biosynthetic process 6.0606 6 yes
GO:0009743 response to carbohydrate 6.0606 4 yes
GO:0009746 response to hexose 6.0606 6 yes
GO:0009749 response to glucose 6.0606 7 yes
GO:0014072 response to isoquinoline alkaloid 6.0606 5 yes
GO:0018130 heterocycle biosynthetic process 6.0606 4 yes
GO:0019438 aromatic compound biosynthetic process 6.0606 4 yes
GO:0032024 positive regulation of insulin secretion 6.0606 7 yes
GO:0032147 activation of protein kinase activity 6.0606 8 yes
GO:0032793 positive regulation of CREB transcription factor activity 6.0606 5 yes
GO:0034284 response to monosaccharide 6.0606 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 6.0606 4 yes
GO:0043278 response to morphine 6.0606 6 yes
GO:0043279 response to alkaloid 6.0606 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ADCY8_HUMAN
DOID:0050700 cardiomyopathy 6.0606 4 no
DOID:0060036 intrinsic cardiomyopathy 6.0606 5 no
DOID:114 heart disease 6.0606 3 no
DOID:2843 long QT syndrome 6.0606 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHKG2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
CA043_HUMAN [view interactions] High throughput no yes
PEX16_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
LEMD2_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes
HACD2_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ANKY2_HUMAN [view interactions] High throughput no no
OMA1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
ADCY4_HUMAN [view interactions] Computational no yes
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
ADCY2_HUMAN [view interactions] Computational no yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
GRM3_HUMAN [view entry] [view interactions] Computational yes no
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
PDE4A_HUMAN [view interactions] Computational no no
PDE4D_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
RPGF3_HUMAN [view interactions] Computational no yes
CREB1_HUMAN [view interactions] Computational no yes
ADCY1_HUMAN [view entry] [view interactions] Computational yes no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
PDE1A_HUMAN [view entry] [view interactions] Computational yes yes
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
GNAL_HUMAN [view interactions] Computational no yes
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes
EDNRA_HUMAN [view interactions] Computational no yes
ADCY7_HUMAN [view interactions] Computational no yes
ADCY6_HUMAN [view interactions] Computational no yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
PDE2A_HUMAN [view entry] [view interactions] Computational yes yes
ADCY5_HUMAN [view interactions] Computational no no
RPGF4_HUMAN [view entry] [view interactions] Computational yes yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
ADCY9_HUMAN [view interactions] Computational no yes
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
EDN1_HUMAN [view interactions] Computational no no
KAPCG_HUMAN [view interactions] Computational no no
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
WFS1_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
GNAO_HUMAN [view entry] [view interactions] Computational yes yes
ADCY3_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
PDE7B_HUMAN [view interactions] Computational no no
PDE4B_HUMAN [view entry] [view interactions] Computational yes yes