ADCY8_HUMAN
Evidence for PS localization
Functions
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADCY8_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 60.0000 | 5 | yes |
| GO:0019888 | protein phosphatase regulator activity | 40.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | yes |
| GO:0043168 | anion binding | 30.0000 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 30.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 30.0000 | 6 | no |
| GO:0008200 | ion channel inhibitor activity | 30.0000 | 5 | no |
| GO:0010853 | cyclase activator activity | 30.0000 | 4 | no |
| GO:0010854 | adenylate cyclase regulator activity | 30.0000 | 4 | no |
| GO:0010856 | adenylate cyclase activator activity | 30.0000 | 5 | no |
| GO:0016248 | channel inhibitor activity | 30.0000 | 4 | no |
| GO:0019209 | kinase activator activity | 30.0000 | 4 | no |
| GO:0019211 | phosphatase activator activity | 30.0000 | 4 | no |
| GO:0019887 | protein kinase regulator activity | 30.0000 | 4 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 30.0000 | 5 | no |
| GO:0030295 | protein kinase activator activity | 30.0000 | 5 | no |
| GO:0031432 | titin binding | 30.0000 | 4 | no |
| GO:0043539 | protein serine/threonine kinase activator activity | 30.0000 | 6 | no |
| GO:0072542 | protein phosphatase activator activity | 30.0000 | 5 | no |
| GO:0099106 | ion channel regulator activity | 30.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADCY8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 70.0000 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 70.0000 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 70.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 70.0000 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 70.0000 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 70.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 70.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 70.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 70.0000 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 60.0000 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 60.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 60.0000 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 60.0000 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 60.0000 | 8 | yes |
| GO:0043085 | positive regulation of catalytic activity | 60.0000 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 60.0000 | 7 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 60.0000 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 60.0000 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 60.0000 | 8 | yes |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 50.0000 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 50.0000 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 50.0000 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 50.0000 | 7 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 50.0000 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 50.0000 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 50.0000 | 4 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 50.0000 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 50.0000 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 50.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 50.0000 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 50.0000 | 7 | no |
| GO:0042326 | negative regulation of phosphorylation | 50.0000 | 8 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 50.0000 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 50.0000 | 6 | no |
| GO:0051726 | regulation of cell cycle | 50.0000 | 4 | no |
| GO:0010038 | response to metal ion | 50.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0051050 | positive regulation of transport | 40.0000 | 4 | yes |
| GO:0051592 | response to calcium ion | 40.0000 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 40.0000 | 6 | no |
| GO:0006942 | regulation of striated muscle contraction | 40.0000 | 7 | no |
| GO:0008016 | regulation of heart contraction | 40.0000 | 6 | no |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 40.0000 | 6 | no |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 40.0000 | 7 | no |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 40.0000 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 40.0000 | 6 | no |
| GO:0019722 | calcium-mediated signaling | 40.0000 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 40.0000 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 40.0000 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 40.0000 | 5 | no |
| GO:0044057 | regulation of system process | 40.0000 | 4 | no |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 40.0000 | 5 | no |
| GO:0051282 | regulation of sequestering of calcium ion | 40.0000 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 40.0000 | 7 | no |
| GO:0055117 | regulation of cardiac muscle contraction | 40.0000 | 7 | no |
| GO:0090257 | regulation of muscle system process | 40.0000 | 5 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 40.0000 | 7 | no |
| GO:1903522 | regulation of blood circulation | 40.0000 | 5 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 40.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 40.0000 | 7 | no |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 40.0000 | 8 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 30.0000 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.0000 | 6 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 30.0000 | 4 | no |
| GO:0000086 | G2/M transition of mitotic cell cycle | 30.0000 | 5 | no |
| GO:0005513 | detection of calcium ion | 30.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
| GO:0010649 | regulation of cell communication by electrical coupling | 30.0000 | 5 | no |
| GO:0010799 | regulation of peptidyl-threonine phosphorylation | 30.0000 | 8 | no |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 30.0000 | 9 | no |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 30.0000 | 9 | no |
| GO:0010921 | regulation of phosphatase activity | 30.0000 | 5 | no |
| GO:0010922 | positive regulation of phosphatase activity | 30.0000 | 6 | no |
| GO:0021762 | substantia nigra development | 30.0000 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0031952 | regulation of protein autophosphorylation | 30.0000 | 8 | no |
| GO:0031954 | positive regulation of protein autophosphorylation | 30.0000 | 9 | no |
| GO:0032410 | negative regulation of transporter activity | 30.0000 | 4 | no |
| GO:0032411 | positive regulation of transporter activity | 30.0000 | 4 | no |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 30.0000 | 5 | no |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 30.0000 | 5 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 30.0000 | 5 | no |
| GO:0032465 | regulation of cytokinesis | 30.0000 | 5 | no |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 30.0000 | 7 | no |
| GO:0034763 | negative regulation of transmembrane transport | 30.0000 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 30.0000 | 5 | no |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 30.0000 | 6 | no |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 30.0000 | 6 | no |
| GO:0035303 | regulation of dephosphorylation | 30.0000 | 7 | no |
| GO:0035304 | regulation of protein dephosphorylation | 30.0000 | 7 | no |
| GO:0035306 | positive regulation of dephosphorylation | 30.0000 | 8 | no |
| GO:0035307 | positive regulation of protein dephosphorylation | 30.0000 | 8 | no |
| GO:0043270 | positive regulation of monoatomic ion transport | 30.0000 | 5 | no |
| GO:0043271 | negative regulation of monoatomic ion transport | 30.0000 | 5 | no |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | 30.0000 | 6 | no |
| GO:0044772 | mitotic cell cycle phase transition | 30.0000 | 4 | no |
| GO:0044839 | cell cycle G2/M phase transition | 30.0000 | 4 | no |
| GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | 30.0000 | 6 | no |
| GO:0050848 | regulation of calcium-mediated signaling | 30.0000 | 6 | no |
| GO:0051051 | negative regulation of transport | 30.0000 | 4 | no |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 30.0000 | 6 | no |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 30.0000 | 6 | no |
| GO:0051284 | positive regulation of sequestering of calcium ion | 30.0000 | 5 | no |
| GO:0051302 | regulation of cell division | 30.0000 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 30.0000 | 4 | no |
| GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity | 30.0000 | 5 | no |
| GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 30.0000 | 6 | no |
| GO:0051345 | positive regulation of hydrolase activity | 30.0000 | 5 | no |
| GO:0051926 | negative regulation of calcium ion transport | 30.0000 | 6 | no |
| GO:0051928 | positive regulation of calcium ion transport | 30.0000 | 6 | no |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 30.0000 | 6 | no |
| GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 30.0000 | 7 | no |
| GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 30.0000 | 7 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 30.0000 | 6 | no |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 30.0000 | 6 | no |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 30.0000 | 6 | no |
| GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction | 30.0000 | 6 | no |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 30.0000 | 7 | no |
| GO:1904063 | negative regulation of cation transmembrane transport | 30.0000 | 7 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 30.0000 | 7 | no |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 30.0000 | 7 | no |
| GO:1904892 | regulation of receptor signaling pathway via STAT | 30.0000 | 5 | no |
| GO:1905912 | regulation of calcium ion export across plasma membrane | 30.0000 | 8 | no |
| GO:1905913 | negative regulation of calcium ion export across plasma membrane | 30.0000 | 8 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.0000 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 30.0000 | 6 | no |
| GO:2001258 | negative regulation of cation channel activity | 30.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.0000 | 4 | yes |
| GO:2001259 | positive regulation of cation channel activity | 30.0000 | 6 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0006915 | apoptotic process | 30.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 30.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 20.0000 | 4 | yes |
| GO:0032880 | regulation of protein localization | 20.0000 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 20.0000 | 5 | yes |
| GO:0050890 | cognition | 20.0000 | 4 | yes |
| GO:0051259 | protein complex oligomerization | 20.0000 | 6 | yes |
| GO:0051260 | protein homooligomerization | 20.0000 | 7 | yes |
| GO:0060341 | regulation of cellular localization | 20.0000 | 4 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 20.0000 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 20.0000 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 20.0000 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| PEX16_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| HACD2_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |