Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLRT2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FLRT2_HUMAN
GO:0000166 nucleotide binding 61.5385 4 no
GO:0003924 GTPase activity 61.5385 7 no
GO:0005525 GTP binding 61.5385 5 no
GO:0016462 pyrophosphatase activity 61.5385 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 61.5385 4 no
GO:0017076 purine nucleotide binding 61.5385 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 61.5385 6 no
GO:0019001 guanyl nucleotide binding 61.5385 6 no
GO:0032555 purine ribonucleotide binding 61.5385 4 no
GO:0032561 guanyl ribonucleotide binding 61.5385 5 no
GO:0035639 purine ribonucleoside triphosphate binding 61.5385 4 no
GO:0043168 anion binding 61.5385 4 no
GO:0019900 kinase binding 53.8462 4 no
GO:0019901 protein kinase binding 53.8462 5 no
GO:0005104 fibroblast growth factor receptor binding 15.3846 5 yes
GO:0045499 chemorepellent activity 15.3846 5 yes
GO:0048018 receptor ligand activity 15.3846 4 yes
GO:0070851 growth factor receptor binding 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FLRT2_HUMAN
GO:0048522 positive regulation of cellular process 92.3077 4 yes
GO:0051128 regulation of cellular component organization 84.6154 4 yes
GO:0030334 regulation of cell migration 69.2308 5 yes
GO:2000145 regulation of cell motility 69.2308 4 yes
GO:0141124 intracellular signaling cassette 61.5385 4 no
GO:0007264 small GTPase-mediated signal transduction 61.5385 5 no
GO:0097435 supramolecular fiber organization 53.8462 4 no
GO:0009893 positive regulation of metabolic process 53.8462 4 no
GO:0031323 regulation of cellular metabolic process 53.8462 4 no
GO:0048523 negative regulation of cellular process 53.8462 4 no
GO:0044087 regulation of cellular component biogenesis 53.8462 4 yes
GO:0051130 positive regulation of cellular component organization 53.8462 5 yes
GO:0006996 organelle organization 53.8462 4 no
GO:0007010 cytoskeleton organization 53.8462 5 no
GO:0007015 actin filament organization 53.8462 5 no
GO:0010604 positive regulation of macromolecule metabolic process 46.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0031344 regulation of cell projection organization 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 46.1538 6 no
GO:0030030 cell projection organization 46.1538 4 yes
GO:0044089 positive regulation of cellular component biogenesis 46.1538 5 yes
GO:0050807 regulation of synapse organization 46.1538 5 yes
GO:0022607 cellular component assembly 46.1538 4 no
GO:0033043 regulation of organelle organization 46.1538 5 no
GO:0030335 positive regulation of cell migration 38.4615 6 no
GO:0040017 positive regulation of locomotion 38.4615 4 no
GO:0042127 regulation of cell population proliferation 38.4615 4 no
GO:0042981 regulation of apoptotic process 38.4615 5 no
GO:0043067 regulation of programmed cell death 38.4615 4 no
GO:2000147 positive regulation of cell motility 38.4615 5 no
GO:0031175 neuron projection development 38.4615 6 yes
GO:0051094 positive regulation of developmental process 38.4615 4 yes
GO:0051240 positive regulation of multicellular organismal process 38.4615 4 yes
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 yes
GO:2000026 regulation of multicellular organismal development 38.4615 4 yes
GO:0010810 regulation of cell-substrate adhesion 38.4615 5 no
GO:0022603 regulation of anatomical structure morphogenesis 38.4615 4 no
GO:0030155 regulation of cell adhesion 38.4615 4 no
GO:0032956 regulation of actin cytoskeleton organization 38.4615 5 no
GO:0032970 regulation of actin filament-based process 38.4615 4 no
GO:0051493 regulation of cytoskeleton organization 38.4615 6 no
GO:0099024 plasma membrane invagination 30.7692 6 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0001934 positive regulation of protein phosphorylation 30.7692 8 no
GO:0006915 apoptotic process 30.7692 4 no
GO:0007266 Rho protein signal transduction 30.7692 6 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0009966 regulation of signal transduction 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0010562 positive regulation of phosphorus metabolic process 30.7692 6 no
GO:0010638 positive regulation of organelle organization 30.7692 6 no
GO:0010646 regulation of cell communication 30.7692 4 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0030855 epithelial cell differentiation 30.7692 4 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0042327 positive regulation of phosphorylation 30.7692 8 no
GO:0045937 positive regulation of phosphate metabolic process 30.7692 7 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:2000377 regulation of reactive oxygen species metabolic process 30.7692 5 no
GO:0051049 regulation of transport 30.7692 4 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 no
GO:0060491 regulation of cell projection assembly 30.7692 5 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 30.7692 6 no
GO:0007411 axon guidance 30.7692 8 yes
GO:0097485 neuron projection guidance 30.7692 7 yes
GO:1901888 regulation of cell junction assembly 30.7692 5 yes
GO:0002685 regulation of leukocyte migration 30.7692 4 no
GO:0010324 membrane invagination 30.7692 5 no
GO:0016055 Wnt signaling pathway 30.7692 4 no
GO:0016601 Rac protein signal transduction 30.7692 6 no
GO:0030031 cell projection assembly 30.7692 5 no
GO:0045785 positive regulation of cell adhesion 30.7692 5 no
GO:0061024 membrane organization 30.7692 4 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 23.0769 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 23.0769 7 no
GO:1902622 regulation of neutrophil migration 23.0769 5 no
GO:0002009 morphogenesis of an epithelium 23.0769 4 no
GO:0002684 positive regulation of immune system process 23.0769 4 no
GO:0002687 positive regulation of leukocyte migration 23.0769 5 no
GO:0010594 regulation of endothelial cell migration 23.0769 5 no
GO:0010632 regulation of epithelial cell migration 23.0769 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0030336 negative regulation of cell migration 23.0769 6 no
GO:0032231 regulation of actin filament bundle assembly 23.0769 5 no
GO:0032233 positive regulation of actin filament bundle assembly 23.0769 6 no
GO:0034446 substrate adhesion-dependent cell spreading 23.0769 4 no
GO:0035567 non-canonical Wnt signaling pathway 23.0769 5 no
GO:0040013 negative regulation of locomotion 23.0769 4 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0051492 regulation of stress fiber assembly 23.0769 6 no
GO:0051495 positive regulation of cytoskeleton organization 23.0769 7 no
GO:0051496 positive regulation of stress fiber assembly 23.0769 7 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 23.0769 6 no
GO:0099159 regulation of modification of postsynaptic structure 23.0769 7 no
GO:0110020 regulation of actomyosin structure organization 23.0769 6 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 no
GO:1902905 positive regulation of supramolecular fiber organization 23.0769 6 no
GO:1905244 regulation of modification of synaptic structure 23.0769 6 no
GO:2000146 negative regulation of cell motility 23.0769 5 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:0010591 regulation of lamellipodium assembly 23.0769 7 no
GO:0010592 positive regulation of lamellipodium assembly 23.0769 7 no
GO:0031346 positive regulation of cell projection organization 23.0769 6 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 23.0769 6 no
GO:1902743 regulation of lamellipodium organization 23.0769 7 no
GO:1902745 positive regulation of lamellipodium organization 23.0769 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.0769 5 yes
GO:0051960 regulation of nervous system development 23.0769 5 yes
GO:0051962 positive regulation of nervous system development 23.0769 5 yes
GO:1901890 positive regulation of cell junction assembly 23.0769 6 yes
GO:0001764 neuron migration 23.0769 4 no
GO:0034329 cell junction assembly 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0001894 tissue homeostasis 23.0769 4 no
GO:0006911 phagocytosis, engulfment 23.0769 7 no
GO:0010811 positive regulation of cell-substrate adhesion 23.0769 6 no
GO:0022604 regulation of cell morphogenesis 23.0769 5 no
GO:0030865 cortical cytoskeleton organization 23.0769 6 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0060326 cell chemotaxis 23.0769 4 no
GO:0003007 heart morphogenesis 15.3846 4 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 15.3846 6 yes
GO:0030198 extracellular matrix organization 15.3846 5 yes
GO:0043062 extracellular structure organization 15.3846 4 yes
GO:0045229 external encapsulating structure organization 15.3846 4 yes
GO:0051963 regulation of synapse assembly 15.3846 6 yes
GO:0051965 positive regulation of synapse assembly 15.3846 6 yes
GO:0071711 basement membrane organization 15.3846 6 yes
GO:2001222 regulation of neuron migration 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AGRL3_HUMAN [view entry] [view interactions] Low throughput yes yes
FLRT1_HUMAN [view interactions] Low throughput no no
FLRT2_HUMAN [view entry] [view interactions] Low throughput yes no
UNC5D_HUMAN [view interactions] Low throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ARL4C_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes