DHPR_HUMAN
Evidence for PS localization
Functions
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DHPR_HUMAN |
|---|---|---|---|---|
| GO:0004155 | 6,7-dihydropteridine reductase activity | 16.6667 | 5 | yes |
| GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | 16.6667 | 4 | yes |
| GO:0050661 | NADP binding | 16.6667 | 4 | yes |
| GO:0051287 | NAD binding | 16.6667 | 4 | yes |
| GO:0070402 | NADPH binding | 16.6667 | 4 | yes |
| GO:0070404 | NADH binding | 16.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DHPR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 41.6667 | 4 | yes |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0009063 | cellular amino acid catabolic process | 25.0000 | 4 | yes |
| GO:0016054 | organic acid catabolic process | 25.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 25.0000 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 25.0000 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 25.0000 | 4 | yes |
| GO:1901606 | alpha-amino acid catabolic process | 25.0000 | 5 | yes |
| GO:1901617 | organic hydroxy compound biosynthetic process | 25.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0006558 | L-phenylalanine metabolic process | 16.6667 | 5 | yes |
| GO:0006559 | L-phenylalanine catabolic process | 16.6667 | 5 | yes |
| GO:0006729 | tetrahydrobiopterin biosynthetic process | 16.6667 | 6 | yes |
| GO:0009072 | aromatic amino acid family metabolic process | 16.6667 | 4 | yes |
| GO:0009074 | aromatic amino acid family catabolic process | 16.6667 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 16.6667 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 16.6667 | 4 | yes |
| GO:0019439 | aromatic compound catabolic process | 16.6667 | 4 | yes |
| GO:0019751 | polyol metabolic process | 16.6667 | 4 | yes |
| GO:0034311 | diol metabolic process | 16.6667 | 5 | yes |
| GO:0034312 | diol biosynthetic process | 16.6667 | 6 | yes |
| GO:0042558 | pteridine-containing compound metabolic process | 16.6667 | 4 | yes |
| GO:0042559 | pteridine-containing compound biosynthetic process | 16.6667 | 5 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 16.6667 | 4 | yes |
| GO:0046146 | tetrahydrobiopterin metabolic process | 16.6667 | 5 | yes |
| GO:0046165 | alcohol biosynthetic process | 16.6667 | 4 | yes |
| GO:0046173 | polyol biosynthetic process | 16.6667 | 5 | yes |
| GO:0051066 | dihydrobiopterin metabolic process | 16.6667 | 5 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 16.6667 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 16.6667 | 4 | yes |
| GO:1902221 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process | 16.6667 | 5 | yes |
| GO:1902222 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DHPR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PH4H_HUMAN | [view interactions] | Low throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL3R2_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| PAGR1_HUMAN | [view interactions] | High throughput | no | yes |
| ELF5_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD6_HUMAN | [view interactions] | High throughput | no | no |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB8_HUMAN | [view interactions] | High throughput | no | yes |
| NCAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPCE_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| TNG2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA6_HUMAN | [view interactions] | High throughput | no | no |
| F169A_HUMAN | [view interactions] | High throughput | no | yes |
| MOCOS_HUMAN | [view interactions] | High throughput | no | no |
| ASM3A_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TY3H_HUMAN | [view interactions] | Computational | no | no |
| DYR_HUMAN | [view interactions] | Computational | no | yes |
| GFRP_HUMAN | [view interactions] | Computational | no | no |
| PHS2_HUMAN | [view interactions] | Computational | no | yes |
| KBL_HUMAN | [view interactions] | Computational | no | yes |
| APT_HUMAN | [view interactions] | Computational | no | yes |
| TPH1_HUMAN | [view interactions] | Computational | no | yes |
| AK1BA_HUMAN | [view interactions] | Computational | no | no |
| RYR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PHS_HUMAN | [view interactions] | Computational | no | yes |
| DYR2_HUMAN | [view interactions] | Computational | no | yes |
| HOT_HUMAN | [view interactions] | Computational | no | no |
| TPH2_HUMAN | [view interactions] | Computational | no | no |
| ALDR_HUMAN | [view interactions] | Computational | no | no |
| RYR1_HUMAN | [view interactions] | Computational | no | no |