Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DHPR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DHPR_HUMAN
GO:0000166 nucleotide binding 27.2727 4 yes
GO:0017076 purine nucleotide binding 27.2727 5 yes
GO:0043168 anion binding 27.2727 4 yes
GO:0004155 6,7-dihydropteridine reductase activity 18.1818 5 yes
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 18.1818 4 yes
GO:0030554 adenyl nucleotide binding 18.1818 6 yes
GO:0050661 NADP binding 18.1818 7 yes
GO:0051287 NAD binding 18.1818 7 yes
GO:0070402 NADPH binding 18.1818 5 yes
GO:0070404 NADH binding 18.1818 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DHPR_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:1901565 organonitrogen compound catabolic process 45.4545 4 yes
GO:0043412 macromolecule modification 45.4545 4 no
GO:0006996 organelle organization 45.4545 4 no
GO:0022607 cellular component assembly 45.4545 4 no
GO:0036211 protein modification process 36.3636 4 no
GO:0043933 protein-containing complex organization 36.3636 4 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0051130 positive regulation of cellular component organization 36.3636 5 no
GO:0065003 protein-containing complex assembly 36.3636 5 no
GO:0009063 amino acid catabolic process 27.2727 4 yes
GO:0016054 organic acid catabolic process 27.2727 4 yes
GO:0019752 carboxylic acid metabolic process 27.2727 5 yes
GO:0043436 oxoacid metabolic process 27.2727 4 yes
GO:0046395 carboxylic acid catabolic process 27.2727 5 yes
GO:1901362 organic cyclic compound biosynthetic process 27.2727 4 yes
GO:1901605 alpha-amino acid metabolic process 27.2727 4 yes
GO:1901606 alpha-amino acid catabolic process 27.2727 5 yes
GO:1901617 organic hydroxy compound biosynthetic process 27.2727 4 yes
GO:0016567 protein ubiquitination 27.2727 8 no
GO:0032446 protein modification by small protein conjugation 27.2727 7 no
GO:0043687 post-translational protein modification 27.2727 5 no
GO:0070647 protein modification by small protein conjugation or removal 27.2727 6 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0007010 cytoskeleton organization 27.2727 5 no
GO:0010638 positive regulation of organelle organization 27.2727 6 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0048523 negative regulation of cellular process 27.2727 4 no
GO:0009059 macromolecule biosynthetic process 27.2727 4 no
GO:0010467 gene expression 27.2727 5 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0009966 regulation of signal transduction 27.2727 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010646 regulation of cell communication 27.2727 4 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0006558 L-phenylalanine metabolic process 18.1818 5 yes
GO:0006559 L-phenylalanine catabolic process 18.1818 6 yes
GO:0006729 tetrahydrobiopterin biosynthetic process 18.1818 6 yes
GO:0009072 aromatic amino acid metabolic process 18.1818 4 yes
GO:0009074 aromatic amino acid family catabolic process 18.1818 5 yes
GO:0019751 polyol metabolic process 18.1818 4 yes
GO:0034311 diol metabolic process 18.1818 5 yes
GO:0034312 diol biosynthetic process 18.1818 6 yes
GO:0042558 pteridine-containing compound metabolic process 18.1818 4 yes
GO:0042559 pteridine-containing compound biosynthetic process 18.1818 5 yes
GO:0046146 tetrahydrobiopterin metabolic process 18.1818 5 yes
GO:0046165 alcohol biosynthetic process 18.1818 4 yes
GO:0046173 polyol biosynthetic process 18.1818 5 yes
GO:0051066 dihydrobiopterin metabolic process 18.1818 5 yes
GO:0170033 L-amino acid metabolic process 18.1818 5 yes
GO:0170035 L-amino acid catabolic process 18.1818 6 yes
GO:0170039 proteinogenic amino acid metabolic process 18.1818 4 yes
GO:0170040 proteinogenic amino acid catabolic process 18.1818 5 yes
GO:1901361 organic cyclic compound catabolic process 18.1818 4 yes
GO:1901566 organonitrogen compound biosynthetic process 18.1818 4 yes
GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 18.1818 5 yes
GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 18.1818 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DHPR_HUMAN [view entry] [view interactions] Low throughput yes no
PH4H_HUMAN [view interactions] Low throughput no no
IQCB1_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
APOA1_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
CASP8_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RL3R2_HUMAN [view interactions] High throughput no no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
AN13A_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
PAGR1_HUMAN [view interactions] High throughput no yes
ELF5_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
PDCD6_HUMAN [view interactions] High throughput no no
GABT_HUMAN [view interactions] High throughput no yes
ARFP1_HUMAN [view interactions] High throughput no no
PUR2_HUMAN [view interactions] High throughput no yes
LGUL_HUMAN [view interactions] High throughput no yes
HDHD1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
DHB8_HUMAN [view interactions] High throughput no yes
NCAM2_HUMAN [view entry] [view interactions] High throughput yes yes
PPCE_HUMAN [view interactions] High throughput no yes
RAE1L_HUMAN [view interactions] High throughput no no
SODC_HUMAN [view interactions] High throughput no yes
SPRE_HUMAN [view interactions] High throughput no yes
TNG2_HUMAN [view interactions] High throughput no yes
ABCA6_HUMAN [view interactions] High throughput no no
F169A_HUMAN [view interactions] High throughput no yes
MOCOS_HUMAN [view interactions] High throughput no no
ASM3A_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no