Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATAT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically acetylates Lys-40 in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ATAT_HUMAN
GO:0019900 kinase binding 42.8571 4 no
GO:0019901 protein kinase binding 42.8571 5 no
GO:0003723 RNA binding 35.7143 4 no
GO:0004860 protein kinase inhibitor activity 28.5714 5 no
GO:0019210 kinase inhibitor activity 28.5714 4 no
GO:0019887 protein kinase regulator activity 28.5714 4 no
GO:0045296 cadherin binding 28.5714 4 no
GO:0045309 protein phosphorylated amino acid binding 28.5714 4 no
GO:0050815 phosphoserine residue binding 28.5714 5 no
GO:0043169 cation binding 21.4286 4 no
GO:0046872 metal ion binding 21.4286 5 no
GO:0140297 DNA-binding transcription factor binding 21.4286 4 no
GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor 14.2857 7 yes
GO:0008080 N-acetyltransferase activity 14.2857 6 yes
GO:0016407 acetyltransferase activity 14.2857 5 yes
GO:0016410 N-acyltransferase activity 14.2857 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14.2857 4 yes
GO:0019799 tubulin N-acetyltransferase activity 14.2857 4 yes
GO:0034212 peptide N-acetyltransferase activity 14.2857 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ATAT_HUMAN
GO:0031323 regulation of cellular metabolic process 78.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 78.5714 4 no
GO:0080090 regulation of primary metabolic process 78.5714 4 no
GO:0048523 negative regulation of cellular process 71.4286 4 no
GO:0048522 positive regulation of cellular process 64.2857 4 yes
GO:0009892 negative regulation of metabolic process 64.2857 4 no
GO:0010605 negative regulation of macromolecule metabolic process 64.2857 5 no
GO:0031324 negative regulation of cellular metabolic process 64.2857 5 no
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0008104 protein localization 57.1429 4 no
GO:0009889 regulation of biosynthetic process 57.1429 4 no
GO:0010468 regulation of gene expression 57.1429 6 no
GO:0010556 regulation of macromolecule biosynthetic process 57.1429 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 57.1429 5 no
GO:0031326 regulation of cellular biosynthetic process 57.1429 5 no
GO:0051252 regulation of RNA metabolic process 57.1429 5 no
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0045595 regulation of cell differentiation 50.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 7 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0006996 organelle organization 42.8571 4 yes
GO:0036211 protein modification process 42.8571 4 yes
GO:0043412 macromolecule modification 42.8571 4 yes
GO:0051726 regulation of cell cycle 42.8571 4 no
GO:0009890 negative regulation of biosynthetic process 42.8571 5 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031327 negative regulation of cellular biosynthetic process 42.8571 6 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0043933 protein-containing complex organization 35.7143 4 yes
GO:0044087 regulation of cellular component biogenesis 35.7143 4 yes
GO:0065003 protein-containing complex assembly 35.7143 5 yes
GO:0051049 regulation of transport 35.7143 4 no
GO:0042981 regulation of apoptotic process 35.7143 5 no
GO:0043067 regulation of programmed cell death 35.7143 4 no
GO:0010563 negative regulation of phosphorus metabolic process 35.7143 6 no
GO:0031400 negative regulation of protein modification process 35.7143 7 no
GO:0032880 regulation of protein localization 35.7143 5 no
GO:0045936 negative regulation of phosphate metabolic process 35.7143 7 no
GO:0051248 negative regulation of protein metabolic process 35.7143 6 no
GO:0060341 regulation of cellular localization 35.7143 4 no
GO:0080134 regulation of response to stress 35.7143 4 no
GO:1902531 regulation of intracellular signal transduction 35.7143 5 no
GO:0032886 regulation of microtubule-based process 28.5714 4 yes
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0051493 regulation of cytoskeleton organization 28.5714 6 yes
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051253 negative regulation of RNA metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0006605 protein targeting 28.5714 4 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0031347 regulation of defense response 28.5714 5 no
GO:0032101 regulation of response to external stimulus 28.5714 4 no
GO:0018193 peptidyl-amino acid modification 21.4286 5 yes
GO:0030030 cell projection organization 21.4286 4 yes
GO:0051130 positive regulation of cellular component organization 21.4286 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 21.4286 5 yes
GO:0070925 organelle assembly 21.4286 5 yes
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 yes
GO:0021762 substantia nigra development 21.4286 4 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.4286 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0043269 regulation of monoatomic ion transport 21.4286 5 no
GO:0045664 regulation of neuron differentiation 21.4286 5 no
GO:0045893 positive regulation of DNA-templated transcription 21.4286 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0050804 modulation of chemical synaptic transmission 21.4286 5 no
GO:0051254 positive regulation of RNA metabolic process 21.4286 6 no
GO:0099177 regulation of trans-synaptic signaling 21.4286 4 no
GO:1902680 positive regulation of RNA biosynthetic process 21.4286 7 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:0006468 protein phosphorylation 21.4286 5 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0010628 positive regulation of gene expression 21.4286 7 no
GO:0016310 phosphorylation 21.4286 5 no
GO:0045787 positive regulation of cell cycle 21.4286 5 no
GO:0090304 nucleic acid metabolic process 21.4286 4 no
GO:0001933 negative regulation of protein phosphorylation 21.4286 8 no
GO:0006469 negative regulation of protein kinase activity 21.4286 7 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0033673 negative regulation of kinase activity 21.4286 6 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0051348 negative regulation of transferase activity 21.4286 5 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0007346 regulation of mitotic cell cycle 21.4286 5 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0045892 negative regulation of DNA-templated transcription 21.4286 8 no
GO:1902679 negative regulation of RNA biosynthetic process 21.4286 7 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:1902532 negative regulation of intracellular signal transduction 21.4286 6 no
GO:0006473 protein acetylation 14.2857 6 yes
GO:0006475 internal protein amino acid acetylation 14.2857 7 yes
GO:0007010 cytoskeleton organization 14.2857 5 yes
GO:0018205 peptidyl-lysine modification 14.2857 6 yes
GO:0018393 internal peptidyl-lysine acetylation 14.2857 8 yes
GO:0018394 peptidyl-lysine acetylation 14.2857 7 yes
GO:0030031 cell projection assembly 14.2857 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 14.2857 6 yes
GO:0043254 regulation of protein-containing complex assembly 14.2857 5 yes
GO:0043543 protein acylation 14.2857 5 yes
GO:0044089 positive regulation of cellular component biogenesis 14.2857 5 yes
GO:0044546 NLRP3 inflammasome complex assembly 14.2857 7 yes
GO:0044782 cilium organization 14.2857 5 yes
GO:0045598 regulation of fat cell differentiation 14.2857 5 yes
GO:0048232 male gamete generation 14.2857 4 yes
GO:0048666 neuron development 14.2857 4 yes
GO:0060271 cilium assembly 14.2857 6 yes
GO:0071929 alpha-tubulin acetylation 14.2857 9 yes
GO:0120031 plasma membrane bounded cell projection assembly 14.2857 6 yes
GO:0140632 canonical inflammasome complex assembly 14.2857 6 yes
GO:1900225 regulation of NLRP3 inflammasome complex assembly 14.2857 6 yes
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 14.2857 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
ATAT_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
ZNRD2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
HERC1_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CYTN_HUMAN [view interactions] High throughput no no
LCN1_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes