Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATAT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically acetylates Lys-40 in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ATAT_HUMAN
GO:0003723 RNA binding 38.4615 4 no
GO:0019900 kinase binding 38.4615 4 no
GO:0019901 protein kinase binding 38.4615 5 no
GO:0046982 protein heterodimerization activity 23.0769 4 no
GO:0140297 DNA-binding transcription factor binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 4 no
GO:0004860 protein kinase inhibitor activity 23.0769 5 no
GO:0019210 kinase inhibitor activity 23.0769 4 no
GO:0019887 protein kinase regulator activity 23.0769 4 no
GO:0045296 cadherin binding 23.0769 4 no
GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor 15.3846 7 yes
GO:0008080 N-acetyltransferase activity 15.3846 6 yes
GO:0016407 acetyltransferase activity 15.3846 5 yes
GO:0016410 N-acyltransferase activity 15.3846 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 15.3846 4 yes
GO:0019799 tubulin N-acetyltransferase activity 15.3846 4 yes
GO:0034212 peptide N-acetyltransferase activity 15.3846 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ATAT_HUMAN
GO:0031323 regulation of cellular metabolic process 76.9231 4 no
GO:0051171 regulation of nitrogen compound metabolic process 76.9231 4 no
GO:0060255 regulation of macromolecule metabolic process 76.9231 4 no
GO:0080090 regulation of primary metabolic process 76.9231 4 no
GO:0048523 negative regulation of cellular process 69.2308 4 no
GO:0006886 intracellular protein transport 61.5385 4 no
GO:0008104 protein localization 61.5385 4 no
GO:0015031 protein transport 61.5385 4 no
GO:0071702 organic substance transport 61.5385 4 no
GO:0071705 nitrogen compound transport 61.5385 4 no
GO:0009892 negative regulation of metabolic process 61.5385 4 no
GO:0010605 negative regulation of macromolecule metabolic process 61.5385 5 no
GO:0048522 positive regulation of cellular process 61.5385 4 yes
GO:0010468 regulation of gene expression 53.8462 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 53.8462 5 no
GO:0051252 regulation of RNA metabolic process 53.8462 5 no
GO:0031324 negative regulation of cellular metabolic process 53.8462 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 53.8462 5 no
GO:0051128 regulation of cellular component organization 53.8462 4 yes
GO:0006355 regulation of DNA-templated transcription 46.1538 6 no
GO:0009889 regulation of biosynthetic process 46.1538 4 no
GO:0010556 regulation of macromolecule biosynthetic process 46.1538 5 no
GO:0010646 regulation of cell communication 46.1538 4 no
GO:0031326 regulation of cellular biosynthetic process 46.1538 5 no
GO:1903506 regulation of nucleic acid-templated transcription 46.1538 7 no
GO:2001141 regulation of RNA biosynthetic process 46.1538 6 no
GO:0022607 cellular component assembly 46.1538 4 yes
GO:0036211 protein modification process 46.1538 4 yes
GO:0043412 macromolecule modification 46.1538 4 yes
GO:0010941 regulation of cell death 38.4615 4 no
GO:0042981 regulation of apoptotic process 38.4615 6 no
GO:0043067 regulation of programmed cell death 38.4615 5 no
GO:0051726 regulation of cell cycle 38.4615 4 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0006605 protein targeting 38.4615 5 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0006996 organelle organization 38.4615 4 yes
GO:0033043 regulation of organelle organization 38.4615 5 yes
GO:0044087 regulation of cellular component biogenesis 38.4615 4 yes
GO:0045595 regulation of cell differentiation 38.4615 4 yes
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010563 negative regulation of phosphorus metabolic process 30.7692 6 no
GO:0031400 negative regulation of protein modification process 30.7692 7 no
GO:0045936 negative regulation of phosphate metabolic process 30.7692 7 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0032886 regulation of microtubule-based process 30.7692 4 yes
GO:0051493 regulation of cytoskeleton organization 30.7692 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 23.0769 5 yes
GO:0070925 organelle assembly 23.0769 5 yes
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 yes
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0021762 substantia nigra development 23.0769 4 no
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0032412 regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0034765 regulation of ion transmembrane transport 23.0769 5 no
GO:0043269 regulation of ion transport 23.0769 5 no
GO:0045664 regulation of neuron differentiation 23.0769 5 no
GO:0045893 positive regulation of DNA-templated transcription 23.0769 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 6 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.0769 5 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0051254 positive regulation of RNA metabolic process 23.0769 6 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.0769 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 23.0769 8 no
GO:1904062 regulation of cation transmembrane transport 23.0769 6 no
GO:0006468 protein phosphorylation 23.0769 5 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010628 positive regulation of gene expression 23.0769 6 no
GO:0010942 positive regulation of cell death 23.0769 5 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0042127 regulation of cell population proliferation 23.0769 4 no
GO:0043065 positive regulation of apoptotic process 23.0769 7 no
GO:0043068 positive regulation of programmed cell death 23.0769 6 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0045787 positive regulation of cell cycle 23.0769 5 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0090304 nucleic acid metabolic process 23.0769 4 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 7 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0043549 regulation of kinase activity 23.0769 5 no
GO:0045859 regulation of protein kinase activity 23.0769 6 no
GO:0051338 regulation of transferase activity 23.0769 4 no
GO:0060548 negative regulation of cell death 23.0769 5 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0080135 regulation of cellular response to stress 23.0769 4 no
GO:0007346 regulation of mitotic cell cycle 23.0769 5 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0045892 negative regulation of DNA-templated transcription 23.0769 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 23.0769 6 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0051253 negative regulation of RNA metabolic process 23.0769 6 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:1902679 negative regulation of RNA biosynthetic process 23.0769 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 23.0769 8 no
GO:0018193 peptidyl-amino acid modification 23.0769 5 yes
GO:0030030 cell projection organization 23.0769 4 yes
GO:0051130 positive regulation of cellular component organization 23.0769 5 yes
GO:0060271 cilium assembly 15.3846 6 yes
GO:0071929 alpha-tubulin acetylation 15.3846 9 yes
GO:0120031 plasma membrane bounded cell projection assembly 15.3846 6 yes
GO:1900225 regulation of NLRP3 inflammasome complex assembly 15.3846 6 yes
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 15.3846 7 yes
GO:0006473 protein acetylation 15.3846 6 yes
GO:0006475 internal protein amino acid acetylation 15.3846 7 yes
GO:0018205 peptidyl-lysine modification 15.3846 6 yes
GO:0018393 internal peptidyl-lysine acetylation 15.3846 8 yes
GO:0018394 peptidyl-lysine acetylation 15.3846 7 yes
GO:0030031 cell projection assembly 15.3846 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 15.3846 6 yes
GO:0043254 regulation of protein-containing complex assembly 15.3846 5 yes
GO:0043543 protein acylation 15.3846 5 yes
GO:0044089 positive regulation of cellular component biogenesis 15.3846 5 yes
GO:0044782 cilium organization 15.3846 5 yes
GO:0045598 regulation of fat cell differentiation 15.3846 5 yes
GO:0048232 male gamete generation 15.3846 4 yes
GO:0048666 neuron development 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
ATAT_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ZNRD2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
HERC1_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CYTN_HUMAN [view interactions] High throughput no no
LCN1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes