Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RFTN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed, PubMed). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed, PubMed). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion . May regulate B-cell antigen receptor-mediated signaling (PubMed). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002323 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RFTN1_HUMAN
GO:0017076 purine nucleotide binding 38.4615 4 no
GO:0032555 purine ribonucleotide binding 38.4615 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 no
GO:0003924 GTPase activity 30.7692 7 no
GO:0005525 GTP binding 30.7692 5 no
GO:0016462 pyrophosphatase activity 30.7692 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.7692 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.7692 6 no
GO:0019001 guanyl nucleotide binding 30.7692 5 no
GO:0019003 GDP binding 30.7692 4 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0032561 guanyl ribonucleotide binding 30.7692 5 no
GO:0003723 RNA binding 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RFTN1_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 no
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0048523 negative regulation of cellular process 61.5385 4 no
GO:0051128 regulation of cellular component organization 61.5385 4 no
GO:0051049 regulation of transport 61.5385 4 no
GO:0008104 protein localization 53.8462 4 yes
GO:0048584 positive regulation of response to stimulus 53.8462 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 yes
GO:0006996 organelle organization 53.8462 4 no
GO:0009966 regulation of signal transduction 53.8462 4 no
GO:0010646 regulation of cell communication 53.8462 4 no
GO:0009893 positive regulation of metabolic process 46.1538 4 yes
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0010941 regulation of cell death 46.1538 4 no
GO:0042981 regulation of apoptotic process 46.1538 6 no
GO:0043067 regulation of programmed cell death 46.1538 5 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0010647 positive regulation of cell communication 46.1538 5 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:1902531 regulation of intracellular signal transduction 46.1538 5 no
GO:0030030 cell projection organization 46.1538 4 no
GO:0120036 plasma membrane bounded cell projection organization 46.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0045595 regulation of cell differentiation 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 yes
GO:0022607 cellular component assembly 38.4615 4 yes
GO:0051240 positive regulation of multicellular organismal process 38.4615 4 yes
GO:0071702 organic substance transport 38.4615 4 yes
GO:0071705 nitrogen compound transport 38.4615 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 38.4615 4 no
GO:0016192 vesicle-mediated transport 38.4615 4 no
GO:0030334 regulation of cell migration 38.4615 5 no
GO:0033043 regulation of organelle organization 38.4615 5 no
GO:2000026 regulation of multicellular organismal development 38.4615 4 no
GO:2000145 regulation of cell motility 38.4615 4 no
GO:0071310 cellular response to organic substance 38.4615 4 no
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 no
GO:0010975 regulation of neuron projection development 38.4615 7 no
GO:0031344 regulation of cell projection organization 38.4615 5 no
GO:0051093 negative regulation of developmental process 38.4615 4 no
GO:0051130 positive regulation of cellular component organization 38.4615 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 no
GO:0031175 neuron projection development 38.4615 6 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0043066 negative regulation of apoptotic process 30.7692 7 no
GO:0043069 negative regulation of programmed cell death 30.7692 6 no
GO:0045596 negative regulation of cell differentiation 30.7692 5 no
GO:0050767 regulation of neurogenesis 30.7692 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0051960 regulation of nervous system development 30.7692 5 no
GO:0060284 regulation of cell development 30.7692 5 no
GO:0060548 negative regulation of cell death 30.7692 5 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0034765 regulation of ion transmembrane transport 30.7692 5 no
GO:0043269 regulation of ion transport 30.7692 5 no
GO:1904062 regulation of cation transmembrane transport 30.7692 6 no
GO:0015031 protein transport 30.7692 4 yes
GO:0006915 apoptotic process 30.7692 4 no
GO:0007010 cytoskeleton organization 30.7692 5 no
GO:0010632 regulation of epithelial cell migration 30.7692 4 no
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0030335 positive regulation of cell migration 30.7692 6 no
GO:0032956 regulation of actin cytoskeleton organization 30.7692 5 no
GO:0032970 regulation of actin filament-based process 30.7692 4 no
GO:0040017 positive regulation of locomotion 30.7692 4 no
GO:0051094 positive regulation of developmental process 30.7692 4 no
GO:0051493 regulation of cytoskeleton organization 30.7692 6 no
GO:2000147 positive regulation of cell motility 30.7692 5 no
GO:0043408 regulation of MAPK cascade 30.7692 6 no
GO:0044087 regulation of cellular component biogenesis 30.7692 4 no
GO:0051129 negative regulation of cellular component organization 30.7692 5 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0008284 positive regulation of cell population proliferation 30.7692 5 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0032102 negative regulation of response to external stimulus 23.0769 5 no
GO:0032990 cell part morphogenesis 23.0769 4 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0048812 neuron projection morphogenesis 23.0769 7 no
GO:0048858 cell projection morphogenesis 23.0769 5 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0050890 cognition 23.0769 4 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 23.0769 7 no
GO:0099173 postsynapse organization 23.0769 4 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.0769 6 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0010720 positive regulation of cell development 23.0769 6 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0050769 positive regulation of neurogenesis 23.0769 6 no
GO:0051962 positive regulation of nervous system development 23.0769 5 no
GO:0006886 intracellular protein transport 23.0769 4 yes
GO:0002009 morphogenesis of an epithelium 23.0769 4 no
GO:0007264 small GTPase mediated signal transduction 23.0769 4 no
GO:0007265 Ras protein signal transduction 23.0769 5 no
GO:0010634 positive regulation of epithelial cell migration 23.0769 5 no
GO:0010942 positive regulation of cell death 23.0769 5 no
GO:0040013 negative regulation of locomotion 23.0769 4 no
GO:0043065 positive regulation of apoptotic process 23.0769 7 no
GO:0043068 positive regulation of programmed cell death 23.0769 6 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:0016197 endosomal transport 23.0769 4 no
GO:0043410 positive regulation of MAPK cascade 23.0769 7 no
GO:0010638 positive regulation of organelle organization 23.0769 6 no
GO:0010977 negative regulation of neuron projection development 23.0769 7 no
GO:0031345 negative regulation of cell projection organization 23.0769 6 no
GO:0032535 regulation of cellular component size 23.0769 4 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0036010 protein localization to endosome 23.0769 6 no
GO:0046578 regulation of Ras protein signal transduction 23.0769 7 no
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0050808 synapse organization 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051051 negative regulation of transport 23.0769 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.0769 6 no
GO:0060627 regulation of vesicle-mediated transport 23.0769 4 no
GO:0060998 regulation of dendritic spine development 23.0769 4 no
GO:0070848 response to growth factor 23.0769 4 no
GO:0071363 cellular response to growth factor stimulus 23.0769 5 no
GO:0097106 postsynaptic density organization 23.0769 6 no
GO:0099084 postsynaptic specialization organization 23.0769 5 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:0150116 regulation of cell-substrate junction organization 23.0769 5 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0030155 regulation of cell adhesion 23.0769 4 no
GO:0001817 regulation of cytokine production 15.3846 4 yes
GO:0002221 pattern recognition receptor signaling pathway 15.3846 4 yes
GO:0002224 toll-like receptor signaling pathway 15.3846 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 15.3846 4 yes
GO:0002684 positive regulation of immune system process 15.3846 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 15.3846 4 yes
GO:0010628 positive regulation of gene expression 15.3846 6 yes
GO:0014070 response to organic cyclic compound 15.3846 4 yes
GO:0045927 positive regulation of growth 15.3846 4 yes
GO:0050776 regulation of immune response 15.3846 4 yes
GO:0050778 positive regulation of immune response 15.3846 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 15.3846 5 yes
GO:0050853 B cell receptor signaling pathway 15.3846 6 yes
GO:0061024 membrane organization 15.3846 4 yes
GO:0071709 membrane assembly 15.3846 5 yes
GO:0072657 protein localization to membrane 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CXB7_HUMAN [view interactions] High throughput no no
U119A_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no
TGM5_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
BTK_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
RBG1L_HUMAN [view interactions] High throughput no yes
ATG2A_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CERS2_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
MUS81_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no