Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RFTN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed, PubMed). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed, PubMed). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion . May regulate B-cell antigen receptor-mediated signaling (PubMed). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002323 MOD_NMyristoyl MOD 1 7 -
ELMI002323 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RFTN1_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0003924 GTPase activity 26.6667 7 no
GO:0005525 GTP binding 26.6667 5 no
GO:0016462 pyrophosphatase activity 26.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.6667 6 no
GO:0019001 guanyl nucleotide binding 26.6667 6 no
GO:0019003 GDP binding 26.6667 5 no
GO:0032561 guanyl ribonucleotide binding 26.6667 5 no
GO:0003723 RNA binding 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RFTN1_HUMAN
GO:0048522 positive regulation of cellular process 80.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0051049 regulation of transport 60.0000 4 no
GO:0051128 regulation of cellular component organization 60.0000 4 no
GO:0008104 protein localization 60.0000 4 yes
GO:0048584 positive regulation of response to stimulus 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 53.3333 4 yes
GO:0009966 regulation of signal transduction 53.3333 4 no
GO:0010646 regulation of cell communication 53.3333 4 no
GO:0030030 cell projection organization 46.6667 4 no
GO:0120036 plasma membrane bounded cell projection organization 46.6667 5 no
GO:1902531 regulation of intracellular signal transduction 46.6667 5 no
GO:2000026 regulation of multicellular organismal development 46.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 yes
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0010975 regulation of neuron projection development 40.0000 7 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0031175 neuron projection development 40.0000 6 no
GO:0031344 regulation of cell projection organization 40.0000 5 no
GO:0042981 regulation of apoptotic process 40.0000 5 no
GO:0043067 regulation of programmed cell death 40.0000 4 no
GO:0045595 regulation of cell differentiation 40.0000 4 no
GO:0050767 regulation of neurogenesis 40.0000 6 no
GO:0051093 negative regulation of developmental process 40.0000 4 no
GO:0051960 regulation of nervous system development 40.0000 5 no
GO:0060284 regulation of cell development 40.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 no
GO:0006996 organelle organization 40.0000 4 no
GO:0141124 intracellular signaling cassette 40.0000 4 no
GO:0006915 apoptotic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 40.0000 4 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0045596 negative regulation of cell differentiation 33.3333 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0050890 cognition 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 yes
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0072657 protein localization to membrane 33.3333 4 yes
GO:0080134 regulation of response to stress 33.3333 4 yes
GO:0010648 negative regulation of cell communication 26.6667 5 no
GO:0010720 positive regulation of cell development 26.6667 6 no
GO:0010721 negative regulation of cell development 26.6667 6 no
GO:0010977 negative regulation of neuron projection development 26.6667 7 no
GO:0019220 regulation of phosphate metabolic process 26.6667 6 no
GO:0023057 negative regulation of signaling 26.6667 4 no
GO:0030335 positive regulation of cell migration 26.6667 6 no
GO:0031345 negative regulation of cell projection organization 26.6667 6 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0031401 positive regulation of protein modification process 26.6667 7 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0033365 protein localization to organelle 26.6667 5 no
GO:0040017 positive regulation of locomotion 26.6667 4 no
GO:0042127 regulation of cell population proliferation 26.6667 4 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0043066 negative regulation of apoptotic process 26.6667 6 no
GO:0043069 negative regulation of programmed cell death 26.6667 5 no
GO:0043408 regulation of MAPK cascade 26.6667 6 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0045597 positive regulation of cell differentiation 26.6667 5 no
GO:0048585 negative regulation of response to stimulus 26.6667 4 no
GO:0048812 neuron projection morphogenesis 26.6667 5 no
GO:0050769 positive regulation of neurogenesis 26.6667 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 26.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 no
GO:0051241 negative regulation of multicellular organismal process 26.6667 4 no
GO:0051246 regulation of protein metabolic process 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0051962 positive regulation of nervous system development 26.6667 5 no
GO:0060627 regulation of vesicle-mediated transport 26.6667 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 26.6667 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.6667 6 no
GO:2000147 positive regulation of cell motility 26.6667 5 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 26.6667 5 no
GO:0043269 regulation of monoatomic ion transport 26.6667 5 no
GO:0007612 learning 26.6667 4 no
GO:0034330 cell junction organization 26.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 26.6667 5 no
GO:0050807 regulation of synapse organization 26.6667 5 no
GO:0050808 synapse organization 26.6667 5 no
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0097106 postsynaptic density organization 26.6667 6 no
GO:0099084 postsynaptic specialization organization 26.6667 5 no
GO:0099177 regulation of trans-synaptic signaling 26.6667 4 no
GO:0007264 small GTPase-mediated signal transduction 26.6667 5 no
GO:0015031 protein transport 26.6667 4 yes
GO:0032103 positive regulation of response to external stimulus 26.6667 5 yes
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0008284 positive regulation of cell population proliferation 26.6667 5 no
GO:0009968 negative regulation of signal transduction 26.6667 5 no
GO:0010632 regulation of epithelial cell migration 26.6667 4 no
GO:0002684 positive regulation of immune system process 20.0000 4 yes
GO:0002831 regulation of response to biotic stimulus 20.0000 4 yes
GO:0002833 positive regulation of response to biotic stimulus 20.0000 5 yes
GO:0006886 intracellular protein transport 20.0000 4 yes
GO:0031347 regulation of defense response 20.0000 5 yes
GO:0031349 positive regulation of defense response 20.0000 5 yes
GO:0045088 regulation of innate immune response 20.0000 5 yes
GO:0045089 positive regulation of innate immune response 20.0000 6 yes
GO:0050776 regulation of immune response 20.0000 4 yes
GO:0050778 positive regulation of immune response 20.0000 5 yes
GO:0001817 regulation of cytokine production 13.3333 4 yes
GO:0002221 pattern recognition receptor signaling pathway 13.3333 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 13.3333 4 yes
GO:0002758 innate immune response-activating signaling pathway 13.3333 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 13.3333 4 yes
GO:0009891 positive regulation of biosynthetic process 13.3333 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 13.3333 6 yes
GO:0010628 positive regulation of gene expression 13.3333 7 yes
GO:0014070 response to organic cyclic compound 13.3333 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 13.3333 6 yes
GO:0045927 positive regulation of growth 13.3333 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 13.3333 5 yes
GO:0050853 B cell receptor signaling pathway 13.3333 6 yes
GO:0061024 membrane organization 13.3333 4 yes
GO:0071709 membrane assembly 13.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CXB7_HUMAN [view interactions] High throughput no no
U119A_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no
TGM5_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
BTK_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
RBG1L_HUMAN [view interactions] High throughput no yes
ATG2A_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CERS2_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
MUS81_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes