Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

5HT4R_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 5HT4R_HUMAN
GO:0004930 G protein-coupled receptor activity 37.5000 4 yes
GO:0008227 G protein-coupled amine receptor activity 37.5000 5 yes
GO:0004993 G protein-coupled serotonin receptor activity 25.0000 6 yes
GO:0099589 serotonin receptor activity 25.0000 4 yes
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0031701 angiotensin receptor binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in 5HT4R_HUMAN
GO:0001894 tissue homeostasis 50.0000 4 yes
GO:0001932 regulation of protein phosphorylation 50.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 no
GO:0006898 receptor-mediated endocytosis 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0042325 regulation of phosphorylation 50.0000 7 no
GO:0042327 positive regulation of phosphorylation 50.0000 8 no
GO:0043408 regulation of MAPK cascade 50.0000 6 no
GO:0043410 positive regulation of MAPK cascade 50.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051050 positive regulation of transport 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0098657 import into cell 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:0006355 regulation of DNA-templated transcription 37.5000 7 no
GO:0009059 macromolecule biosynthetic process 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 37.5000 4 no
GO:0051094 positive regulation of developmental process 37.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0090304 nucleic acid metabolic process 37.5000 4 no
GO:0141187 nucleic acid biosynthetic process 37.5000 5 no
GO:1901362 organic cyclic compound biosynthetic process 37.5000 4 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0001817 regulation of cytokine production 37.5000 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0009890 negative regulation of biosynthetic process 37.5000 5 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010629 negative regulation of gene expression 37.5000 7 no
GO:0015031 protein transport 37.5000 4 no
GO:0030100 regulation of endocytosis 37.5000 5 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 37.5000 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 37.5000 8 no
GO:0071702 organic substance transport 37.5000 4 no
GO:0071705 nitrogen compound transport 37.5000 4 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:0002683 negative regulation of immune system process 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway 25.0000 5 no
GO:0007179 transforming growth factor beta receptor signaling pathway 25.0000 7 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0031348 negative regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032102 negative regulation of response to external stimulus 25.0000 5 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050777 negative regulation of immune response 25.0000 5 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 25.0000 6 no
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 25.0000 7 no
GO:0062207 regulation of pattern recognition receptor signaling pathway 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0141091 transforming growth factor beta receptor superfamily signaling pathway 25.0000 6 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 25.0000 4 yes
GO:0007268 chemical synaptic transmission 25.0000 7 yes
GO:0007589 body fluid secretion 25.0000 4 yes
GO:0010669 epithelial structure maintenance 25.0000 5 yes
GO:0030277 maintenance of gastrointestinal epithelium 25.0000 4 yes
GO:0046903 secretion 25.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 25.0000 6 yes
GO:0099536 synaptic signaling 25.0000 4 yes
GO:0099537 trans-synaptic signaling 25.0000 5 yes
GO:0120054 intestinal motility 25.0000 4 yes
GO:0120056 large intestinal transit 25.0000 5 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 25.0000 7 no
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin 25.0000 6 no
GO:0003018 vascular process in circulatory system 25.0000 4 no
GO:0006351 DNA-templated transcription 25.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0006366 transcription by RNA polymerase II 25.0000 7 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0016070 RNA metabolic process 25.0000 5 no
GO:0022401 negative adaptation of signaling pathway 25.0000 6 no
GO:0023058 adaptation of signaling pathway 25.0000 5 no
GO:0032091 negative regulation of protein binding 25.0000 5 no
GO:0032774 RNA biosynthetic process 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045453 bone resorption 25.0000 5 no
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 25.0000 6 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 25.0000 9 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051100 negative regulation of binding 25.0000 4 no
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 25.0000 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 25.0000 8 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 no
GO:0001818 negative regulation of cytokine production 25.0000 5 no
GO:0002031 G protein-coupled receptor internalization 25.0000 6 no
GO:0002090 regulation of receptor internalization 25.0000 7 no
GO:0002092 positive regulation of receptor internalization 25.0000 7 no
GO:0006508 proteolysis 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0008593 regulation of Notch signaling pathway 25.0000 5 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0010498 proteasomal protein catabolic process 25.0000 5 no
GO:0016567 protein ubiquitination 25.0000 8 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0030038 contractile actin filament bundle assembly 25.0000 6 no
GO:0030163 protein catabolic process 25.0000 4 no
GO:0031032 actomyosin structure organization 25.0000 4 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031397 negative regulation of protein ubiquitination 25.0000 10 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0031623 receptor internalization 25.0000 5 no
GO:0032088 negative regulation of NF-kappaB transcription factor activity 25.0000 5 no
GO:0032446 protein modification by small protein conjugation 25.0000 7 no
GO:0032675 regulation of interleukin-6 production 25.0000 5 no
GO:0032715 negative regulation of interleukin-6 production 25.0000 6 no
GO:0043149 stress fiber assembly 25.0000 5 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0043433 negative regulation of DNA-binding transcription factor activity 25.0000 4 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0043687 post-translational protein modification 25.0000 5 no
GO:0045807 positive regulation of endocytosis 25.0000 5 no
GO:0048259 regulation of receptor-mediated endocytosis 25.0000 6 no
GO:0048260 positive regulation of receptor-mediated endocytosis 25.0000 6 no
GO:0051017 actin filament bundle assembly 25.0000 5 no
GO:0051056 regulation of small GTPase mediated signal transduction 25.0000 6 no
GO:0051057 positive regulation of small GTPase mediated signal transduction 25.0000 7 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no
GO:0061572 actin filament bundle organization 25.0000 6 no
GO:0070647 protein modification by small protein conjugation or removal 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:1901565 organonitrogen compound catabolic process 25.0000 4 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1901874 negative regulation of post-translational protein modification 25.0000 8 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRK5_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GPR37_HUMAN [view interactions] Low throughput no no
GRIN2_HUMAN [view interactions] Low throughput no yes
5HT4R_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
GGT7_HUMAN [view interactions] High throughput no yes
TM230_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
GDF1_HUMAN [view interactions] High throughput no no
GHITM_HUMAN [view interactions] High throughput no yes
ANO10_HUMAN [view interactions] High throughput no yes
CERS1_HUMAN [view interactions] High throughput no yes
MGLL_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
S39A1_HUMAN [view interactions] High throughput no no
TSN7_HUMAN [view entry] [view interactions] High throughput yes yes
TEFF2_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
CLD10_HUMAN [view interactions] High throughput no no