Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PROD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Converts proline to delta-1-pyrroline-5-carboxylate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PROD_HUMAN
GO:0017076 purine nucleotide binding 60.0000 4 no
GO:0032555 purine ribonucleotide binding 60.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 60.0000 4 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0005524 ATP binding 50.0000 5 no
GO:0030554 adenyl nucleotide binding 50.0000 5 no
GO:0032559 adenyl ribonucleotide binding 50.0000 5 no
GO:0016887 ATP hydrolysis activity 40.0000 7 no
GO:0031625 ubiquitin protein ligase binding 30.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 30.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PROD_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0071310 cellular response to organic substance 50.0000 4 no
GO:0006986 response to unfolded protein 40.0000 4 no
GO:0016192 vesicle-mediated transport 40.0000 4 no
GO:0034620 cellular response to unfolded protein 40.0000 5 no
GO:0035967 cellular response to topologically incorrect protein 40.0000 4 no
GO:0051084 de novo post-translational protein folding 40.0000 4 no
GO:0051085 chaperone cofactor-dependent protein refolding 40.0000 4 no
GO:0006560 proline metabolic process 30.0000 6 yes
GO:0009064 glutamine family amino acid metabolic process 30.0000 5 yes
GO:0010941 regulation of cell death 30.0000 4 yes
GO:0019752 carboxylic acid metabolic process 30.0000 5 yes
GO:0043436 oxoacid metabolic process 30.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 30.0000 4 yes
GO:1901605 alpha-amino acid metabolic process 30.0000 4 yes
GO:0009893 positive regulation of metabolic process 30.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0031323 regulation of cellular metabolic process 30.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0048523 negative regulation of cellular process 30.0000 4 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 30.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 30.0000 4 no
GO:0080090 regulation of primary metabolic process 30.0000 4 no
GO:0006536 glutamate metabolic process 20.0000 6 yes
GO:0006562 proline catabolic process 20.0000 5 yes
GO:0009063 cellular amino acid catabolic process 20.0000 4 yes
GO:0009065 glutamine family amino acid catabolic process 20.0000 6 yes
GO:0010133 proline catabolic process to glutamate 20.0000 6 yes
GO:0010942 positive regulation of cell death 20.0000 5 yes
GO:0016054 organic acid catabolic process 20.0000 4 yes
GO:0019470 4-hydroxyproline catabolic process 20.0000 5 yes
GO:0019471 4-hydroxyproline metabolic process 20.0000 4 yes
GO:0042219 cellular modified amino acid catabolic process 20.0000 4 yes
GO:0043648 dicarboxylic acid metabolic process 20.0000 6 yes
GO:0046395 carboxylic acid catabolic process 20.0000 5 yes
GO:1901606 alpha-amino acid catabolic process 20.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S23A3_HUMAN [view interactions] High throughput no no
BRAP_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
KPRP_HUMAN [view interactions] High throughput no no
TUSC2_HUMAN [view interactions] High throughput no no
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
THTR_HUMAN [view interactions] High throughput no yes
BCAT2_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
ACY1_HUMAN [view interactions] High throughput no no
CAN11_HUMAN [view interactions] High throughput no no
ZDHC8_HUMAN [view interactions] Computational no yes
OAT_HUMAN [view interactions] Computational no yes
AMPL_HUMAN [view entry] [view interactions] Computational yes no
P4HA2_HUMAN [view interactions] Computational no no
P5CR1_HUMAN [view entry] [view interactions] Computational yes yes
AL4A1_HUMAN [view entry] [view interactions] Computational yes yes
P4HA1_HUMAN [view interactions] Computational no yes
P5CS_HUMAN [view interactions] Computational no yes
P5CR2_HUMAN [view interactions] Computational no yes