Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SLIK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed, PubMed). Enhances neuronal dendrite outgrowth (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SLIK1_HUMAN
GO:0004725 protein tyrosine phosphatase activity 33.3333 4 no
GO:0016791 phosphatase activity 33.3333 5 no
GO:0042578 phosphoric ester hydrolase activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SLIK1_HUMAN
GO:0050767 regulation of neurogenesis 66.6667 6 yes
GO:0050807 regulation of synapse organization 66.6667 5 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051960 regulation of nervous system development 66.6667 5 yes
GO:0051963 regulation of synapse assembly 66.6667 6 yes
GO:0060284 regulation of cell development 66.6667 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 66.6667 4 yes
GO:0099560 synaptic membrane adhesion 66.6667 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 66.6667 6 yes
GO:1901888 regulation of cell junction assembly 66.6667 5 yes
GO:2000026 regulation of multicellular organismal development 66.6667 4 yes
GO:0010975 regulation of neuron projection development 66.6667 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 66.6667 4 yes
GO:0031344 regulation of cell projection organization 66.6667 5 yes
GO:0044087 regulation of cellular component biogenesis 66.6667 4 yes
GO:0045595 regulation of cell differentiation 66.6667 4 yes
GO:0045597 positive regulation of cell differentiation 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0050769 positive regulation of neurogenesis 50.0000 6 yes
GO:0050770 regulation of axonogenesis 50.0000 5 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 50.0000 4 yes
GO:0051962 positive regulation of nervous system development 50.0000 5 yes
GO:0051965 positive regulation of synapse assembly 50.0000 6 yes
GO:1901890 positive regulation of cell junction assembly 50.0000 6 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0010720 positive regulation of cell development 50.0000 6 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0031346 positive regulation of cell projection organization 50.0000 6 yes
GO:0044089 positive regulation of cellular component biogenesis 50.0000 5 yes
GO:0048812 neuron projection morphogenesis 33.3333 5 yes
GO:0050772 positive regulation of axonogenesis 33.3333 6 yes
GO:0050808 synapse organization 33.3333 5 yes
GO:0099174 regulation of presynapse organization 33.3333 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 yes
GO:1905606 regulation of presynapse assembly 33.3333 7 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0006470 protein dephosphorylation 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0016311 dephosphorylation 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0099150 regulation of postsynaptic specialization assembly 33.3333 6 no
GO:0099151 regulation of postsynaptic density assembly 33.3333 7 no
GO:0099175 regulation of postsynapse organization 33.3333 6 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:1902115 regulation of organelle assembly 33.3333 5 no
GO:1904889 regulation of excitatory synapse assembly 33.3333 7 no
GO:1905874 regulation of postsynaptic density organization 33.3333 6 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0007409 axonogenesis 33.3333 6 yes
GO:0007416 synapse assembly 33.3333 6 yes
GO:0030030 cell projection organization 33.3333 4 yes
GO:0034329 cell junction assembly 33.3333 5 yes
GO:0034330 cell junction organization 33.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
SLIK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
UBQL2_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes