SLIK1_HUMAN
Evidence for PS localization
Functions
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed, PubMed). Enhances neuronal dendrite outgrowth (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SLIK1_HUMAN |
|---|---|---|---|---|
| GO:0004725 | protein tyrosine phosphatase activity | 40.0000 | 4 | no |
| GO:0016791 | phosphatase activity | 40.0000 | 5 | no |
| GO:0042578 | phosphoric ester hydrolase activity | 40.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SLIK1_HUMAN |
|---|---|---|---|---|
| GO:0010975 | regulation of neuron projection development | 80.0000 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 80.0000 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 80.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 80.0000 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 80.0000 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 80.0000 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 80.0000 | 5 | yes |
| GO:0060284 | regulation of cell development | 80.0000 | 5 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 80.0000 | 4 | yes |
| GO:0099560 | synaptic membrane adhesion | 80.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 80.0000 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 80.0000 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 60.0000 | 6 | yes |
| GO:0022607 | cellular component assembly | 60.0000 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 60.0000 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 60.0000 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 60.0000 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 60.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 60.0000 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 60.0000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 60.0000 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 60.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 60.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 60.0000 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 60.0000 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 60.0000 | 6 | yes |
| GO:0051965 | positive regulation of synapse assembly | 60.0000 | 6 | yes |
| GO:0099174 | regulation of presynapse organization | 60.0000 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 60.0000 | 5 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 60.0000 | 6 | yes |
| GO:1905606 | regulation of presynapse assembly | 60.0000 | 7 | yes |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 60.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 60.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 60.0000 | 4 | no |
| GO:0007409 | axonogenesis | 40.0000 | 8 | yes |
| GO:0007416 | synapse assembly | 40.0000 | 6 | yes |
| GO:0030030 | cell projection organization | 40.0000 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 40.0000 | 4 | yes |
| GO:0034329 | cell junction assembly | 40.0000 | 5 | yes |
| GO:0034330 | cell junction organization | 40.0000 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 40.0000 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 40.0000 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 40.0000 | 6 | yes |
| GO:0050808 | synapse organization | 40.0000 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 40.0000 | 6 | yes |
| GO:0006470 | protein dephosphorylation | 40.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | no |
| GO:0016311 | dephosphorylation | 40.0000 | 5 | no |
| GO:0036211 | protein modification process | 40.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | no |
| GO:0050776 | regulation of immune response | 40.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |