CA2D3_HUMAN
Evidence for PS localization
Functions
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CA2D3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 75.0000 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 75.0000 | 4 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 75.0000 | 6 | yes |
| GO:0005261 | cation channel activity | 75.0000 | 5 | yes |
| GO:0005262 | calcium channel activity | 75.0000 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 75.0000 | 6 | yes |
| GO:0015267 | channel activity | 75.0000 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 75.0000 | 6 | yes |
| GO:0022836 | gated channel activity | 75.0000 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 75.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 75.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0008331 | high voltage-gated calcium channel activity | 37.5000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CA2D3_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 100.0000 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 75.0000 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 75.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 75.0000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 62.5000 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 62.5000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 62.5000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 50.0000 | 6 | no |
| GO:0051924 | regulation of calcium ion transport | 50.0000 | 7 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 50.0000 | 7 | no |
| GO:1904062 | regulation of cation transmembrane transport | 50.0000 | 6 | no |
| GO:0006811 | ion transport | 37.5000 | 4 | no |
| GO:0006812 | cation transport | 37.5000 | 5 | no |
| GO:0006816 | calcium ion transport | 37.5000 | 7 | no |
| GO:0030001 | metal ion transport | 37.5000 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 37.5000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0007528 | neuromuscular junction development | 37.5000 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 37.5000 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 37.5000 | 5 | no |
| GO:0034330 | cell junction organization | 37.5000 | 4 | no |
| GO:0050808 | synapse organization | 37.5000 | 5 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 37.5000 | 6 | no |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 37.5000 | 7 | no |
| GO:2001257 | regulation of cation channel activity | 37.5000 | 6 | no |
| GO:0070509 | calcium ion import | 25.0000 | 8 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0001933 | negative regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0006469 | negative regulation of protein kinase activity | 25.0000 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0033673 | negative regulation of kinase activity | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043086 | negative regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0050708 | regulation of protein secretion | 25.0000 | 5 | no |
| GO:0050709 | negative regulation of protein secretion | 25.0000 | 6 | no |
| GO:0050807 | regulation of synapse organization | 25.0000 | 5 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:0051048 | negative regulation of secretion | 25.0000 | 5 | no |
| GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051223 | regulation of protein transport | 25.0000 | 5 | no |
| GO:0051224 | negative regulation of protein transport | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051348 | negative regulation of transferase activity | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0099175 | regulation of postsynapse organization | 25.0000 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:1903531 | negative regulation of secretion by cell | 25.0000 | 5 | no |
| GO:1903828 | negative regulation of protein localization | 25.0000 | 5 | no |
| GO:1904950 | negative regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0050776 | regulation of immune response | 25.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0060402 | calcium ion transport into cytosol | 25.0000 | 4 | no |
| GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 25.0000 | 7 | no |
| GO:0070588 | calcium ion transmembrane transport | 25.0000 | 6 | no |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
| GO:0097553 | calcium ion transmembrane import into cytosol | 25.0000 | 7 | no |
| GO:0098655 | cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 5 | no |
| GO:0019932 | second-messenger-mediated signaling | 25.0000 | 4 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| RA51C_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFSWA_HUMAN | [view interactions] | High throughput | no | yes |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| GGEE3_HUMAN | [view interactions] | High throughput | no | no |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CACB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1A_HUMAN | [view interactions] | Computational | no | no |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |