DGLA_HUMAN
Evidence for PS localization
Functions
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed, PubMed, PubMed). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed, PubMed, PubMed). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DGLA_HUMAN |
|---|---|---|---|---|
| GO:0016298 | lipase activity | 50.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0047372 | acylglycerol lipase activity | 50.0000 | 5 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 50.0000 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0008509 | anion transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0015103 | inorganic anion transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0015108 | chloride transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DGLA_HUMAN |
|---|---|---|---|---|
| GO:0001676 | long-chain fatty acid metabolic process | 50.0000 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 50.0000 | 4 | yes |
| GO:0006690 | icosanoid metabolic process | 50.0000 | 6 | yes |
| GO:0016042 | lipid catabolic process | 50.0000 | 4 | yes |
| GO:0019369 | arachidonic acid metabolic process | 50.0000 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 50.0000 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 50.0000 | 6 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 50.0000 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 50.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0006638 | neutral lipid metabolic process | 37.5000 | 4 | yes |
| GO:0006639 | acylglycerol metabolic process | 37.5000 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 37.5000 | 4 | yes |
| GO:0046461 | neutral lipid catabolic process | 37.5000 | 5 | yes |
| GO:0046464 | acylglycerol catabolic process | 37.5000 | 6 | yes |
| GO:0046486 | glycerolipid metabolic process | 37.5000 | 4 | yes |
| GO:0046503 | glycerolipid catabolic process | 37.5000 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0007215 | glutamate receptor signaling pathway | 25.0000 | 4 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 25.0000 | 4 | yes |
| GO:0007405 | neuroblast proliferation | 25.0000 | 4 | yes |
| GO:0022008 | neurogenesis | 25.0000 | 4 | yes |
| GO:0031347 | regulation of defense response | 25.0000 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 25.0000 | 4 | yes |
| GO:0038171 | cannabinoid signaling pathway | 25.0000 | 4 | yes |
| GO:0042136 | neurotransmitter biosynthetic process | 25.0000 | 4 | yes |
| GO:0050727 | regulation of inflammatory response | 25.0000 | 5 | yes |
| GO:0071926 | endocannabinoid signaling pathway | 25.0000 | 5 | yes |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | yes |
| GO:0098917 | retrograde trans-synaptic signaling | 25.0000 | 5 | yes |
| GO:0098920 | retrograde trans-synaptic signaling by lipid | 25.0000 | 6 | yes |
| GO:0098921 | retrograde trans-synaptic signaling by endocannabinoid | 25.0000 | 7 | yes |
| GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | yes |
| GO:0099541 | trans-synaptic signaling by lipid | 25.0000 | 5 | yes |
| GO:0099542 | trans-synaptic signaling by endocannabinoid | 25.0000 | 6 | yes |
| GO:0019216 | regulation of lipid metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0045834 | positive regulation of lipid metabolic process | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0046462 | monoacylglycerol metabolic process | 25.0000 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0050805 | negative regulation of synaptic transmission | 25.0000 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0052651 | monoacylglycerol catabolic process | 25.0000 | 7 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0006811 | ion transport | 25.0000 | 4 | no |
| GO:0006812 | cation transport | 25.0000 | 5 | no |
| GO:0030001 | metal ion transport | 25.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:0051223 | regulation of protein transport | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:0003018 | vascular process in circulatory system | 25.0000 | 4 | no |
| GO:0035150 | regulation of tube size | 25.0000 | 4 | no |
| GO:0035296 | regulation of tube diameter | 25.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0097746 | blood vessel diameter maintenance | 25.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKLF7_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAL_HUMAN | [view interactions] | High throughput | no | no |
| UPK1B_HUMAN | [view interactions] | High throughput | no | no |
| M4A13_HUMAN | [view interactions] | High throughput | no | no |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| TARG1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| ABD12_HUMAN | [view interactions] | Computational | no | no |
| FAAH2_HUMAN | [view interactions] | Computational | no | no |
| ABHD6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NAPEP_HUMAN | [view interactions] | Computational | no | yes |
| CNR1_HUMAN | [view interactions] | Computational | no | yes |
| DGLB_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FAAH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |