DGLA_HUMAN
Evidence for PS localization
Functions
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed, PubMed, PubMed). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed, PubMed, PubMed). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DGLA_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 60.0000 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 40.0000 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0015103 | inorganic anion transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0015108 | chloride transmembrane transporter activity | 40.0000 | 5 | no |
| GO:0015267 | channel activity | 40.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 40.0000 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 40.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DGLA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 40.0000 | 5 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0006811 | monoatomic ion transport | 40.0000 | 4 | no |
| GO:0006812 | monoatomic cation transport | 40.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0030001 | metal ion transport | 40.0000 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKLF7_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| MALL_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAL_HUMAN | [view interactions] | High throughput | no | no |
| UPK1B_HUMAN | [view interactions] | High throughput | no | no |
| M4A13_HUMAN | [view interactions] | High throughput | no | no |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| TARG1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| DGLB_HUMAN | [view interactions] | High throughput | no | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |